Standout Papers
Citation Impact
Citing Papers
miR-375 maintains normal pancreatic α- and β-cell mass
2009
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1
2013
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
2015 Science
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
2007 Science
Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126
2008
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
2015 Science
Stimulation of Piezo1 by mechanical signals promotes bone anabolism
2019
Dysregulated mi RNA biogenesis downstream of cellular stress and ALS ‐causing mutations: a new mechanism for ALS
2015
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
2017
The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size
2015
Deletion of the miR-143/145 Cluster Leads to Hydronephrosis in Mice
2014
High‐throughput identification of RNA nuclear enrichment sequences
2018
CRISPR/Cas9-mediated targeted chromosome elimination
2017
Precision cancer mouse models through genome editing with CRISPR-Cas9
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling
2017
The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis
2013
Long Noncoding RNAs in Development and Regeneration of the Neural Lineage
2019
microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice
2012
Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP
2015
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins
2015
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
2015
Emerging tools for bioluminescence imaging
2021
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
2009
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
2017
miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal
2016
Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
2018
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
2019
Calcium signalling: dynamics, homeostasis and remodelling
2003 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis
2015
A Shh/miR-206/BDNF Cascade Coordinates Innervation and Formation of Airway Smooth Muscle
2011
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Small non-coding RNAs in animal development
2008
MicroRNAs in the Human Heart
2007
Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c
2016 StandoutNobel
MicroRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin/nNOS Pathway
2010
Dnm3os, a non‐coding RNA, is required for normal growth and skeletal development in mice
2008
Serum response factor: toggling between disparate programs of gene expression
2003
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy
2015
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
2008
miR-142-3p enhances FcεRI-mediated degranulation in mast cells
2013
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
rVISTA 2.0: evolutionary analysis of transcription factor binding sites
2004
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Regulation of intraocular pressure by microRNA cluster miR-143/145
2017
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
2018
The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development
2019
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
2015
Decoding ALS: from genes to mechanism
2016 StandoutNature
MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
2007
Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy
2011
Therapeutic genome editing: prospects and challenges
2015
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
2011 Standout
Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury
2012
Metazoan MicroRNAs
2018 Standout
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
2005 Nature
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene
2018
Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals
2018
Building strong bones: molecular regulation of the osteoblast lineage
2011
Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination
2020
The Role of Muscle microRNAs in Repairing the Neuromuscular Junction
2014
Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
2007
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis
2015
MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart
2007
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Towards a complete map of the human long non-coding RNA transcriptome
2018
The emerging roles of YAP and TAZ in cancer
2015
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
2005 Standout
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
A conserved MST1/2–YAP axis mediates Hippo signaling during lung growth
2015
miR-1/133a Clusters Cooperatively Specify the Cardiomyogenic Lineage by Adjustment of Myocardin Levels during Embryonic Heart Development
2013
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
2003 StandoutNature
Regulation of Neuroregeneration by Long Noncoding RNAs
2018
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
2009
MicroRNAs as Potential Circulating Biomarkers for Amyotrophic Lateral Sclerosis
2014
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
MicroRNAs in Stress Signaling and Human Disease
2012
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Engineering the Delivery System for CRISPR-Based Genome Editing
2018
MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death
2012
Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes
2012
MicroRNA-140 plays dual roles in both cartilage development and homeostasis
2010
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Importance of Long Non-coding RNAs in the Development and Disease of Skeletal Muscle and Cardiovascular Lineages
2019
The Transcription Factor Mef2 Links the Drosophila Core Clock to Fas2, Neuronal Morphology, and Circadian Behavior
2013 StandoutNobel
A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance
2009
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
2017
Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
2012
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
2017 StandoutNobel
Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation
2018
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
2014
LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56
2016
Perspective: Embryo editing needs scrutiny
2015 StandoutNatureNobel
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Distinct and dynamic myogenic populations in the vertebrate embryo
2009
Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
2004 Standout
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Regulation of gene expression by cis-acting long non-coding RNAs
2019
Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor
2001
The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids
2013
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Characterization of the Mouse Aortic Carboxypeptidase-Like Protein Promoter Reveals Activity in Differentiated and Dedifferentiated Vascular Smooth Muscle Cells
2002
When Long Noncoding Becomes Protein Coding
2020
Hippo signaling impedes adult heart regeneration
2013
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
1983 StandoutNobel
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
2015
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Hippo Pathway Regulation of Gastrointestinal Tissues
2014
Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies
2015
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
PUMILIO hyperactivity drives premature aging of Norad-deficient mice
2019
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
1981 StandoutNatureNobel
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
1980 StandoutNatureNobel
Altered microRNA expression in human heart disease
2007
In vivo genome editing improves motor function and extends survival in a mouse model of ALS
2017
MicroRNA-206 Is Highly Expressed in Newly Formed Muscle Fibers: Implications Regarding Potential for Muscle Regeneration and Maturation in Muscular Dystrophy
2008
Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome
1980 StandoutNatureNobel
Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*
2012
Potentiation of serum response factor activity by a family of myocardin-related transcription factors
2002
Cell-Specific Regulatory Modules Control Expression of Genes in Vascular and Visceral Smooth Muscle Tissues
2002
Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing
2018
Myocardin Is a Critical Serum Response Factor Cofactor in the Transcriptional Program Regulating Smooth Muscle Cell Differentiation
2003
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
2014
miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis
2014
Combinatorial Control of Smooth Muscle–Specific Gene Expression
2003
A complete immunoglobulin gene is created by somatic recombination
1978
The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2
2019
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
2008 Standout
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments
1979 StandoutNatureNobel
Immunoglobulin Gene Rearrangement in Immature B Cells
1980 StandoutScienceNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes
1981 StandoutNatureNobel
microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart
2013
The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap
2014
Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model
2014
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Sequences at the somatic recombination sites of immunoglobulin light-chain genes
1979 StandoutNatureNobel
miR‐145 regulates myofibroblast differentiation and lung fibrosis
2013
Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators
2013
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
2014
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of John McAnally being referenced
Control of muscle formation by the fusogenic micropeptide myomixer
2017 Science
Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA
2014 Science
MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice
2009 Science
Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy
2015 Science
MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development
2007
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
2008 Standout
Cardiac-Specific Activity of an Nkx2–5 Enhancer Requires an Evolutionarily Conserved Smad Binding Site
2002
In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
2019
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
2004 Nature
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
2009
Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development
2016 Nature
A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance
2015
Tbx1is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer
2003
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice
2008
Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis
2004
Muscle Specificity Encoded by Specific Serum Response Factor-binding Sites
2001
Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice
2005
Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486
2010
CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice
2017
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
2007
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
2016 Science
Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size
2011
Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c
2007
Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance
2008
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
2002
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function
2008
C/EBP Transcription Factors Mediate Epicardial Activation During Heart Development and Injury
2012 Science
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
2006
Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers
2007
Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy
2017
Hippo pathway effector Yap promotes cardiac regeneration
2013