Standout Papers
- 2-Chloroethyl (methylsulfonyl)methanesulfonate (NSC-338947), a more selective DNA alkylating agent than the chloroethylnitrosoureas. (1986)
Citation Impact
Citing Papers
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
2009 Standout
Relationship between the neurotoxicity of the hypoxic cell radiosensitizer SR 2508 and the pharmacokinetic profile.
1987
Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
2016
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Biochemistry of growth inhibition by ammonium ions in mammalian cells
1994
Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases
2008 StandoutNobel
Methods for Predicting Human Drug Metabolism
2006
Chemotherapy for malignant gliomas
1988
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
2012 Standout
Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect
2016
Cannabinoid receptor-inactive N -acylethanolamines and other fatty acid amides: metabolism and function
2002
Ritonavir
1998
Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative.
1996 Standout
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2008 Standout
Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners
2004 Standout
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Metabolism and action of amino acid analog anti-cancer agents
1990
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides
2007 StandoutNobel
Radiosensitization by 2-nitroimidazole nucleoside analog rp-170: Radiosensitizing effects under both intravenous and oral administration
1992 StandoutNobel
Nasopharyngeal carcinoma
2019 Standout
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)
2008
Clinical Pharmacokinetic and Pharmacodynamic Profile of the HIV Integrase Inhibitor Elvitegravir
2011
Radiosensitization by a new potent nucleoside analog: 1-(1′,3′,4′-trihydroxy-2′-butoxy)methyl-2-nitroimidazole(RP-343)
1993 StandoutNobel
The versatility and universality of calcium signalling
2000 Standout
Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole (RP-170)
1989 StandoutNobel
Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function
1995
In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism
2002
Metabolic Delivery of Ketone Groups to Sialic Acid Residues
1998 StandoutNobel
The 1987 Walter Hubert lecture: Regulation and deficiencies in DNA repair
1987 StandoutNobel
The microenvironment of the tumour–host interface
2001 StandoutNature
A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients
2010
Effect of Tenofovir Disoproxil Fumarate on the Pharmacokinetics and Pharmacodynamics of Total, R‐, and S‐Methadone
2004
Anodic Oxidation of Ifosfamide and Cyclophosphamide
2001
Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V)
2001
The biochemistry and toxicology of benzoic acid metabolism and its relationship to the elimination of waste nitrogen
1993
Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate
2012
Pharmacogenetics goes genomic
2003
Relationships between carboplatin exposure and tumor response and toxicity in patients with ovarian cancer.
1992 Standout
Paradoxical roles of the immune system during cancer development
2006 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
The ChEMBL database in 2017
2016 Standout
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Herb-Drug Interactions
2005 Standout
Liposomal drug delivery systems: From concept to clinical applications
2012 Standout
The anti-angiogenic basis of metronomic chemotherapy
2004 Standout
The Enzymatic Basis for the Dehydrogenation of 3-Phenylpropionic Acid: In Vitro Reaction of 3- Phenylpropionyl-CoA with Various Acyl-CoA Dehydrogenases
1990
Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring
2014 StandoutNobel
A marker for Stevens–Johnson syndrome
2004 StandoutNature
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
2010
Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial
2013 Standout
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
2012 StandoutNobel
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
2007 Standout
The development of an oral prodrug, SR-2545, of the 2-nitroimidazole radiosensitizer SR-2508
1982
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Standards of laboratory practice: cardiac drug monitoring
1998
Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.
1986
Enhanced Growth of Primary Tumors in Cancer-Prone Mice after Immunization against the Mutant Region of an Inherited Oncoprotein
1999
A growing role for mTOR in promoting anabolic metabolism
2013
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Understanding the Dose-Effect Relationship
1981
A clinical phase I toxicity study of Ro 03–8799: plasma, urine, tumour and normal brain pharmacokinetics
1986
Repeated observation of breast tumor subtypes in independent gene expression data sets
2003 Standout
In vivo NMR Studies of the Glutamate Neurotransmitter Flux and Neuroenergetics: Implications for Brain Function
2003
Synthesis, Self-Assembly, and Nonlinear Optical Properties of Conjugated Helical Metal Phthalocyanine Derivatives
1999 StandoutNobel
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction.
2001
The structure and energy of SiH+5. comparisons with CH+5 and BH5
1983 StandoutNobel
Multiplex Assay for Comprehensive Genotyping of Genes Involved in Drug Metabolism, Excretion, and Transport
2007
Display-oriented data system for multiple ion detection with gas chromatography-mass spectrometry in quantifying biomedically important compounds
1973
Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers.
1996
Hypoxia-Inducible Factor 1 and Cardiovascular Disease
2013 StandoutNobel
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors.
1999
Ambulatory electrocardiography and the diagnosis, evaluation, and treatment of chronic ventricular arrhythmias
1980
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Regulate to reduce chemical mixture risk
2018 StandoutScience
Phase I trial of the hypoxic cell radiosensitizer SR-2508: The results of the five to six week drug schedule
1986
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Pharmacokinetic Interactions of Drugs with St John’s Wort
2004
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
The Chemistry of Neutron Capture Therapy
1998 Standout
DNA Cross-Linking Agents as Antitumor Drugs
1998
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Formation of A Dihydroxy Metabolite of Phenytoin in Human Liver Microsomes/cytosol: Roles of Cytochromes P450 2c9, 2c19, and 3a4
2000
Proton affinities of neutral molecules
1980
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water.
2002
Identification and assay of tetranor-prostaglandin E1 in human urine
1976 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Radiosensitization, Pharmacokinetics, and Toxicity of a 2-Nitroimidazole Nucleoside (RA-263)
1986
Desorption ionization mass spectrometry and laser photodissociation of porphyrins and related compounds
1989
A Prospective Evaluation and Follow-up of Patients with Syncope
1983 Standout
TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer.
2003
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of John M. Strong being referenced
Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo
1995
Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study
2009
Effect of Albumin on the Estimation, In Vitro, of Phenytoin Vmax and Km Values: Implications for Clinical Correlation
1997
Quantitation of 4-hydroxycyclophosphamide/aldophosphamide in whole blood
1995
Stimulation of uracil nucleotide synthesis in mouse liver, intestine and kidney by ammonium chloride infusion
1988
Oxime Derivatives of the Intermediary Oncostatic Metabolites of Cyclophosphamide and Ifosfamide: Synthesis and Deuterium Labeling for Applications to Metabolite Quantification
1995
Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro
2002
Dose‐ranging trial of N‐acetylprocainamide in patients with premature ventricular contractions
1977
Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro.
1998
An Evaluation of the Hemizygous Transgenic Tg.AC Mouse for Carcinogenicity Testing of Pharmaceuticals. I. Evidence for a Confounding Nonresponder Phenotype
1998
Desorption Ionization Mass Spectrometry of Synthetic Porphyrins
1984
2-Chloroethyl (methylsulfonyl)methanesulfonate (NSC-338947), a more selective DNA alkylating agent than the chloroethylnitrosoureas.
1986 StandoutNobel
Effects of 5-fluorouracil substitution on the RNA conformation and in vitro translation of thymidylate synthase messenger RNA.
1993
Determination of cerebral glucose transport and metabolic kinetics by dynamic MR spectroscopy
1997
Phase I trial of N-(phosphonacetyl)-L-aspartate.
1979
Simultaneous measurement of plasma concentratons of lidocaine and its deethylated metabolite by mass fragmentography
1972
Fast atom bombardment: Evidence of disproportionation and recombination of a synthetic porphyrin in the matrix
1983
Proton affinity of trimethylphosphine
1970
Initial pharmacology and toxicology of intravenous desmethylmisonidazole
1982
Contribution of de‐novo and salvage synthesis to the uracil nucleotide pool in mouse tissues and tumors in vivo
1992
THE CONVULSANT POTENCY OF LIDOCAINE AND ITS N-DEALKYLATED METABOLITES
1973
Clinical pharmacology of 5-iodo-2′-deoxyuridine and 5-iodouracil and endogenous pyrimidine modulation
1985
Antiarrhythmic potency of N‐acetylprocainamide
1975
In vitro glucuronidation of D-23129, a new anticonvulsant, by human liver microsomes and liver slices
1997
Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man.
1976
Application of a simple competitive protein-binding assay technique to the pharmacokinetics of N-(phosphonacetyl)-L-aspartate in humans.
1980
Stability and Comparative Metabolism of Selected Felbamate Metabolites and Postulated Fluorofelbamate Metabolites by Postmitochondrial Suspensions
2005
The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone.
1997
Pharmacokinetics of intraventricular and intravenous N,N',N''-triethylenethiophosphoramide (thiotepa) in rhesus monkeys and humans.
1986
Scientific Perspectives on Drug Transporters and Their Role in Drug Interactions
2006