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3 The Medicinal Chemistry of the Azido Group
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Severe Neurologic Deficit after Nitrous Oxide Anesthesia
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1989 StandoutNobel
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1988 StandoutNobel
High-pressure liquid chromatography separation and determination of rat liver folates
1981
Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present.
1990
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2003 StandoutNobel
Gold Nanoparticles in Chemical and Biological Sensing
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The folate cofactor of Escherichia coli DNA photolyase acts catalytically.
1990 StandoutNobel
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1982
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2000
Effect of Dietary Patterns on Serum Homocysteine
2000
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults
1999
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
alpha-Carboxyl-linked glutamates in the folylpolyglutamates of Escherichia coli.
1986
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
1998
Contents of Vitamins, Mineral Elements, and Some Phenolic Compounds in Cultivated Mushrooms
2001 Standout
Cleavage of naturally occurring folates to unsubstituted p-aminobenzoylpoly-γ-glutamates
1980
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Genes, folate and homocysteine in embryonic development
2001
Is dietary intake of methionine associated with a reduction in risk for neural tube defect-affected pregnancies?
1997
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
1997 StandoutNobel
Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity
2000
Maternal epigenetics and methyl supplements affect agouti gene expression in A vy /a mice
1998
Prevention of neural tube defects: Results of the Medical Research Council vitamin study
1992 Standout
Evaluating Novel Cardiovascular Risk Factors: Can We Better Predict Heart Attacks?
1999
L-Threonine Dehydrase as a Model of Allosteric Control Involving Ligand-lnduced Oligomerization
1975
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
1997
Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach
2002 StandoutNobel
Agonist-induced increase in apparent β-adrenergic receptor size
1978 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics.
1981
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair
1997 StandoutNobel
Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye
2014
Effects and safety of periconceptional oral folate supplementation for preventing birth defects
2015
Works of John M. Scott being referenced
Homocysteine Is Lower in the Third Trimester of Pregnancy in Women with Enhanced Folate Status from Continued Folic Acid Supplementation
2004
Effects of the disruption of transmethylation in the central nervous system: an animal model
1994
Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
2006
The association-dissociation of formyltetrahydrofolate synthetase and its relation to monovalent cation activation of catalytic activity
1967
Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method
1997
MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae
2005
The genetic background of thecurly tailstrain confers susceptibility to folate‐deficiency‐induced exencephaly
2009
Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study
2004
Methionine Synthase: High-Resolution Mapping of the Human Gene and Evaluation as a Candidate Locus for Neural Tube Defects
1999
MTRR and MTHFR polymorphism: Link to Down syndrome?
2001
Are common mutations of cystathionine β‐synthase involved in the aetiology of neural tube defects?
1997
Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients
1991
Lipid peroxidation induced in vivo by hyperhomocysteinaemia in pigs
1997
Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters
2013
Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia
2003
A Polymorphism, R653Q, in the Trifunctional Enzyme Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase/Formyltetrahydrofolate Synthetase Is a Maternal Genetic Risk Factor for Neural Tube Defects: Report of the Birth Defects Research Group
2002
Testing reported associations of genetic risk factors for oral clefts in a large Irish study population
2009
Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations
1997
The relationship between increased folate catabolism and the increased requirement for folate in pregnancy
2000
Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects
1996
Elevated plasma homocysteine in early pregnancy: A risk factor for the development of severe preeclampsia
2001
The influence of 5,10 methylenetetrahydrofolate reductase genotypes on enzyme activity in placental tissue
1999
Vitamin B12 and folate deficiency in later life
2003
The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study
2002
Homocysteine and Ischemic Heart Disease
1998
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function
2008
Maternal and fetal plasma homocysteine concentrations at birth: The influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C→T variant
2002
A polymorphism in the MTHFD1 gene increases a mother’s risk of having an unexplained second trimester pregnancy loss
2005
Accelerated folate breakdown in pregnancy
1993
Homocysteine and Neural Tube Defects
1996
The “Thermolabile” Variant of Methylenetetrahydrofolate Reductase and Neural Tube Defects: An Evaluation of Genetic Risk and the Relative Importance of the Genotypes of the Embryo and the Mother
1999
Minimum effective dose of folic acid for food fortification to prevent neural-tube defects
1997
Determining bioavailability of food folates in a controlled intervention study
2004
The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels
2006
Folate Metabolism in Pregnancy
1993
Analysis of the MTHFR 1298A→C and 677C→T polymorphisms as risk factors for neural tube defects
2003
Homocysteine metabolism in pregnancies complicated by neural-tube defects
1995
Folate‐related gene polymorphisms as risk factors for cleft lip and cleft palate
2008
Randomized Trial of Folic Acid Supplementation and Serum Homocysteine Levels
2001
Detection of Vitamin B12 Deficiency in Older People by Measuring Vitamin B12 or the Active Fraction of Vitamin B12, Holotranscobalamin
2007
Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry
1998
Maternal serum folate and vitamin B12 concentrations in pregnancies associated with neural tube defects.
1985
Maternal Homocysteine before Conception and throughout Pregnancy Predicts Fetal Homocysteine and Birth Weight
2004
The identification of pteroylpentaglutamate as the major folate derivative in rat liver and the demonstration of its biosynthesis from exogenous [3H] pteroylglutamate
1972
Folate, Related B Vitamins, and Homocysteine in Childhood and Adolescence: Potential Implications for Disease Risk in Later Life
2009
The Identification of the Intracellular Folate Coenzymes of Different Cell Types
1976
Microbial Synthesis of Folate Polyglutamates from Labelled Precursors
1974
Human Bone Marrow Biochemical Function and Megaloblastic Hematopoiesis after Nitrous Oxide Anesthesia
1981
Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.
1998
The fate of folate polyglutamates in meat during storage and processing
1976
Folate Composition, Synthesis and Function in Natural Materials
1976
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects
1995
Folic acid deficiency in the United States: Folate assays in a prenatal clinic
1975
How does folic acid prevent neural tube defects?
1998
Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part II: Biochemical and Genetic Analysis
2008
Mechanism of choline O-sulphate utilization in fungi
1968
Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: Low folate status alone may be the critical factor
1998
Distribution Studies on Polyglutamate Forms of Folate
1976
Methylenetetrahydrofolate reductase thermolabile variant and oral clefts
1999
Folate Coenzymes of Clostridium acidi-urici
1972
Distribution of Pteroylpoly-γ-l -glutamates in Rat Liver
1973
Analysis of the human folate receptor β gene for an association with neural tube defects
2003
Effect of selenium status and supplementation with high‐selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly
2008
Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion
2004
Chemistry and biology of pteridines 1986
1987
Evaluation of Novel Assays in Clinical Chemistry: Quantification of Plasma Total Homocysteine
2000