Standout Papers

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1 2011 2026 2016 2021 952
  1. Ebola virus entry requires the cholesterol transporter Niemann–Pick C1 (2011)
    Jan E. Carette, Matthijs Raaben et al. Nature

Citation Impact

Citing Papers

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
Gene essentiality and synthetic lethality in haploid human cells
2015 Science
Identification and characterization of essential genes in the human genome
2015 Science
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
2016
Current pharmacological treatments for COVID‐19: What's next?
2020
Elucidating Design Principles for Engineering Cell‐Derived Vesicles to Inhibit SARS‐CoV‐2 Infection
2022
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Identification of interferon-stimulated genes that attenuate Ebola virus infection
2020 StandoutNobel
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
2019
Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice
2017
Viral membrane fusion
2015
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity
2019
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins
2022 StandoutNobel
Massively multiplex single-cell Hi-C
2017
RNAi screening comes of age: improved techniques and complementary approaches
2014
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus
2018
A view on drug resistance in cancer
2019 StandoutNature
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Accurate classification of BRCA1 variants with saturation genome editing
2018 Nature
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
2013
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
2015
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
2012
A CRISPR toolbox to study virus–host interactions
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells
2015
Genetic screens in isogenic mammalian cell lines without single cell cloning
2020
Cell Death
2004 Standout
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal
2003
Point-of-care testing based on smartphone: The current state-of-the-art (2017–2018)
2019
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses
2020
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
2020 StandoutNobel
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread
2017 StandoutNobel
Ebola Virus Entry: A Curious and Complex Series of Events
2015
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets
2018
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
2020 Standout
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
An RNA-centric dissection of host complexes controlling flavivirus infection
2019 StandoutNobel
A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies Parp1 as a Mediator of Olaparib Toxicity
2013
Positive Selection Drives Evolution at the Host–Filovirus Interaction Surface
2016
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal  -dystroglycan O-mannosylation, independent from sialic acid
2014
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
2014
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
2018 StandoutNobel
Bispecific antibodies: a mechanistic review of the pipeline
2019
Interferon-γ Inhibits Ebola Virus Infection
2015
Comprehensive Integration of Single-Cell Data
2019 Standout
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
2016 StandoutNobel
LYSOSOMAL STORAGE DISEASES
1991
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
2016 Nature
Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses
2014
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Sialic Acid Glycoengineering Using an Unnatural Sialic Acid for the Detection of Sialoglycan Biosynthesis Defects and On-Cell Synthesis of Siglec Ligands
2015
Are RNA Viruses Candidate Agents for the Next Global Pandemic? A Review
2017
Lectins:  Carbohydrate-Specific Proteins That Mediate Cellular Recognition
1998 Standout
Diagnosing COVID-19: The Disease and Tools for Detection
2020 Standout
Hunting Viral Receptors Using Haploid Cells
2015
Selectable One-Step PCR-Mediated Integration of a Degron for Rapid Depletion of Endogenous Human Proteins
2016
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus
2019
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Replication-Deficient Ebolavirus as a Vaccine Candidate
2009
Reshaping de Novo Protein Switches into Bioresponsive Materials for Biomarker, Toxin, and Viral Detection
2022 StandoutNobel
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody
2020 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
The Pathogenesis of Ebola Virus Disease
2016
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Genetic Dissection of the Host Tropism of Human-Tropic Pathogens
2015

Works of John M. Dye being referenced

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
2020 Science
A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
2016 Science
Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins
2018
Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann–Pick C1
2014
Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys
2017
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
2011 StandoutNature
Toll-Like Receptor Agonist Augments Virus-Like Particle-Mediated Protection from Ebola Virus with Transient Immune Activation
2014
Ebola virus entry requires the host‐programmed recognition of an intracellular receptor
2012
Control of Lymphocytic Choriomeningitis Virus Infection in Granzyme B Deficient Mice
2002
Homologous and Heterologous Protection of Nonhuman Primates by Ebola and Sudan Virus-Like Particles
2015
A Serological Point-of-Care Test for the Detection of IgG Antibodies against Ebola Virus in Human Survivors
2018
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion
2015
Lassa virus entry requires a trigger-induced receptor switch
2014 Science
A Characterization of Aerosolized Sudan Virus Infection in African Green Monkeys, Cynomolgus Macaques, and Rhesus Macaques
2012
Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013
2013
Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo
2015
Protective Cytotoxic T-Cell Responses Induced by Venezuelan Equine Encephalitis Virus Replicons Expressing Ebola Virus Proteins
2005
A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge
2011
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
2017
Structural Basis for Differential Neutralization of Ebolaviruses
2012
Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus
2011
Rankless by CCL
2026