Citation Impact
Citing Papers
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components
2005 StandoutNobel
Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes
2000
Heparan Sulfate Proteoglycans as Extracellular Docking Molecules for Matrilysin (Matrix Metalloproteinase 7)
2000
The Matrix Metalloproteinase 9 (MMP-9) Hemopexin Domain Is a Novel Gelatin Binding Domain and Acts as an Antagonist
2002
Matrix metalloproteinase expression during experimental autoimmune neuritis
1998
Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance
1999
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
2001
Signal transduction via platelet-derived growth factor receptors
1998
Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation
2000
Inflammation and cancer
2002 StandoutNature
Role of Matrix Metalloproteinases in Abdominal Aortic Aneurysmsa
1996
Catalytic activities of membrane‐type 6 matrix metalloproteinase (MMP25)
2001
Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor
1998
Immunoglobulin-like Domain 4-mediated Receptor-Receptor Interactions Contribute to Platelet-derived Growth Factor-induced Receptor Dimerization
1997
A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms
2008 StandoutNobel
Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1
2001
Role of Immunoglobulin-like Domains 2–4 of the Platelet-derived Growth Factor α-Receptor in Ligand-Receptor Complex Assembly
1998
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome
2001
Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library
1995
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
Tissue inhibitors of metalloproteinases: evolution, structure and function
2000 Standout
Degradation of Interleukin 1β by Matrix Metalloproteinases
1996
Apoptosis by Death Factor
1997 Standout
A structural superfamily of growth factors containing a cystine knot motif
1993
X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily
1996
Guillain-Barré syndrome
2016 Standout
Abdominal aortic aneurysm
2005 Standout
Involvement of chemokine receptors in breast cancer metastasis
2001 StandoutNature
Involvement of Loop 2 of Platelet-Derived Growth Faetor-AA and-BB in Receptor Binding
1995
HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration
2003
Strategies for MMP inhibition in cancer: innovations for the post-trial era
2002
Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase
1999
Secretion and Surface Display of Green Fluorescent Protein Using the Yeast Saccharomyces cerevisiae
2005
Matrix metalloproteinases and diseases of the CNS
1998
Lymphocyte Trafficking and Regional Immunity
1999
A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis
1997
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
2006
Epilysin, a Novel Human Matrix Metalloproteinase (MMP-28) Expressed in Testis and Keratinocytes and in Response to Injury
2001
Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases
2002
Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site
1997
Sequence and gene organization of the chicken mitochondrial genome
1990
Matrix Metalloproteinases: Potential Therapeutic Target in Spinal Cord Injury
2001
Blood–brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: an in vitro study
2013
Preclinical and Clinical Studies of MMP Inhibitors in Cancer
1999
TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo
2000
Immunotherapy in autoimmune neuromuscular disorders
2002
Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution
1997
Mediators of Chronic Obstructive Pulmonary Disease
2004
Cellular Activation of MMP-2 (Gelatinase A) by MT2-MMP Occurs via a TIMP-2-independent Pathway
2001
TIMP-2 and PAI-1 mRNA levels are lower in aneurysmal as compared to athero-occlusive abdominal aortas
2003
Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption
2000
Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins
1998
Identification of Insulin-like Growth Factor-binding Protein-1 as a Potential Physiological Substrate for Human Stromelysin-3
1997
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism
2005
Matrix metalloproteinases as modulators of inflammation and innate immunity
2004 Standout
Resistance of young gelatinase B–deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions
1999
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor
1998
Structural properties of matrix metalloproteinases
1999
Biochemical Characterization of the Catalytic Domain of Human Matrix Metalloproteinase 19
2000
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Matrix Metalloproteinases Collagenase-2, Macrophage Elastase, Collagenase-3, and Membrane Type 1-Matrix Metalloproteinase Impair Clotting by Degradation of Fibrinogen and Factor XII
2000
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
.alpha.- And .beta.-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure
1990
Atherosclerosis — An Inflammatory Disease
1999 Standout
Topological similarities in TGF-β2, PDGF-BB and NGF define a superfamily of polypeptide growth factors
1993
The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
1999
The role of nitric oxide in multiple sclerosis
2002
The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains
1995
Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB‐78485 inhibitor
2008
Binding of Active (57 kDa) Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to Tissue Inhibitor of Metalloproteinase (TIMP)-2 Regulates MT1-MMP Processing and Pro-MMP-2 Activation
2000
Matrix metalloproteinases degrade myelin basic protein
1995
Specific collagenolysis by gelatinase A, MMP‐2, is determined by the hemopexin domain and not the fibronectin‐like domain
2001
Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions
1996
Gelatinase B/matrix metalloproteinase‐9 cleaves interferon‐β and is a target for immunotherapy
2003
Carbohydrate recognition systems: functional triads in cell—cell interactions
1996
Differential Roles of TIMP-4 and TIMP-2 in Pro-MMP-2 Activation by MT1-MMP
2001
fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
1994 StandoutNobel
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
1997 StandoutNature
Cellular activation of proMMP‐13 by MT1‐MMP depends on the C‐terminal domain of MMP‐13
2002
Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2
2000
Cancer-related inflammation
2008 StandoutNature
Antimicrobial peptides of multicellular organisms
2002 StandoutNature
Neutrophil rolling altered by inhibition of L-selectin shedding in vitro
1996 Nature
Polymyositis and dermatomyositis
2003 Standout
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 Å resolution
1998
Crystal Structure of the Extracellular Domain from P0, the Major Structural Protein of Peripheral Nerve Myelin
1996
Involvement of the Mural Thrombus as a Site of Protease Release and Activation in Human Aortic Aneurysms
2002
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
1997 StandoutNatureNobel
Elevated Expression of Matrix Metalloproteinase-13 in Abdominal Aortic Aneurysms
2004
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Matrix Metalloproteinases
1999 Standout
Molecular Determinants of Metalloproteinase Substrate Specificity: Matrix Metalloproteinase Substrate Binding Domains, Modules, and Exosites
2002
Cleavage of Syndecan-1 by Membrane Type Matrix Metalloproteinase-1 Stimulates Cell Migration
2003
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Macrophage Metalloelastase Mediates Acute Cigarette Smoke–induced Inflammation via Tumor Necrosis Factor-α Release
2003
Termination and post-termination events in eukaryotic translation
2012
Expression of matrix metalloproteinases in the muscle of patients with inflammatory myopathies
2000
Crystal structure of human platelet-derived growth factor BB.
1992
Metalloproteinases Are Involved in Lipopolysaccharide– and Tumor Necrosis Factor-–Mediated Regulation of CXCR1 and CXCR2 Chemokine Receptor Expression
1999
Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule.
1992
A novel role of metalloproteinase in cancer-mediated immunosuppression.
2001
Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes
2011
Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4
2010
Analysis of tissue inhibitor of metalloproteinases-2 effect on pro-matrix metalloproteinase-2 activation by membrane-type 1 matrix metalloproteinase using baculovirus/insect-cell expression system
2000
Circular permutation and receptor insertion within green fluorescent proteins
1999 StandoutNobel
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
1995 StandoutNobel
Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E–Deficient Mice Against Atherosclerotic Media Destruction but Differentially Affects Plaque Growth
2004
Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.
1996 StandoutNobel
Genetics of Guillain‐Barré syndrome (GBS ) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP ): current knowledge and future directions
2014
Gelatinase B modulates selective opening of the blood-brain barrier during inflammation
1998
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
1997
Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.
2002 Standout
THE GREEN FLUORESCENT PROTEIN
1998 StandoutNobel
Kinetic Analysis of the Zinc-Dependent Deacetylase in the Lipid A Biosynthetic Pathway
2005
Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization
1998
Independent origins of New Zealand moas and kiwis.
1992 StandoutNobel
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
2002
Genetic approach to the role of cysteine proteases in the expansion of abdominal aortic aneurysms
2004
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP- N - acetylgalactosamine, and UDP-galactose
2001 StandoutNobel
Binding of Uridine 5‘-Diphosphate in the “Basic Patch” of the Zinc Deacetylase LpxC and Implications for Substrate Binding,
2006
Inhibition of Lipid A Biosynthesis as the Primary Mechanism of CHIR-090 Antibiotic Activity in Escherichia coli
2007
Refined Solution Structure of the LpxC−TU-514 Complex and pKa Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design,
2005
Making the cut: Protease-mediated regulation of angiogenesis
2006
Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia
2001
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
2004 StandoutNobel
The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1
1999
The Molecular Mechanics of Eukaryotic Translation
2004
Domain structure of a mammalian myosin I beta.
1994 StandoutNobel
The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae
1988 StandoutScienceNobel
Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia
2001
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
Matrix metalloproteinases: structures, evolution, and diversification
1998
Matrix Metalloproteinase Inhibition After Myocardial Infarction
2001
Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan
2003
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
2001 Standout
The distal ectodomain of angiotensin-converting enzyme regulates its cleavage-secretion from the cell surface
1998
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Inhibitory DNA Ligands to Platelet-Derived Growth Factor B-Chain
1996
Angiotensin-converting enzyme and male fertility
1998 StandoutNobel
Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex
2012 StandoutNobel
Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats
1998
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Matrix metalloproteinase-9 is increased and correlates with severity in Guillain-Barre syndrome
1999
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.
1996
Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes
1999
Guillain–Barré syndrome, CIDP and other chronic immune‐mediated neuropathies
1998
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
2003 Standout
Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.
1995
Crystal Structure of Hemolin: A Horseshoe Shape with Implications for Homophilic Adhesion
1998 Science
Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94
2000
Metalloproteinase inhibitors: biological actions and therapeutic opportunities
2002
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.
2002
The scanning model for translation: an update.
1989 Standout
Hypoxia‐inducible factor regulates osteoclast‐mediated bone resorption: role of angiopoietin‐like 4
2010
Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3
2000 Science
A Slow, Tight-Binding Inhibitor of the Zinc-Dependent Deacetylase LpxC of Lipid A Biosynthesis with Antibiotic Activity Comparable to Ciprofloxacin
2005
Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans.
1987
Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense
1999 Science
A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
1995 StandoutNobel
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
2002
Uridine-Based Inhibitors as New Leads for Antibiotics Targeting Escherichia coli LpxC
2009 StandoutNobel
Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
2004 Standout
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
2007
Matrix Metalloproteinases and Cardiovascular Disease
1995
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
1999 Standout
Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
2004 StandoutNobel
Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis
2002
Works of John M. Clements being referenced
Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 Å resolution
1995 Nature
Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor
1997
Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview
1997
Processing of tumour necrosis factor-α precursor by metalloproteinases
1994 Nature
Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors
1998
Molecular cloning of the 3-phosphoglycerate kinase (PGK) gene from Aspergillus nidulans
1985
Secretion of human epidermal growth factor from Saccharomyces cerevisiae using synthetic leader sequences
1991
The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A
1998
Differential expression of matrix metalloproteinases in bacterial meningitis
1999
mRNA sequences influencing translation and the selection of AUG initiator codons in the yeast Saccharomyces cerevisiae
1996
Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions
1997
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS
1998
Matrix metalloproteinases MMP‐9 and MMP‐7 are expressed in experimental autoimmune neuritis and the guillain‐barré syndrome
1998
Expression of specific matrix metalloproteinases in inflammatory myopathies
2001
Distinct binding specificities of integrins α4β7 (LPAM-1), α4β1 (VLA-4), and αIELβ7
1994
Efficiency of Translation Initiation by Non-AUG Codons inSaccharomyces cerevisiae
1988
Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin
1994
Generation of Human Umbilical Vein Endothelial Cell Lines Which Maintain Their Differentiated Phenotype
1994
Antibacterial Activities and Characterization of Novel Inhibitors of LpxC
2002
Stromelysin-1 (Matrix Metalloproteinase-3) and Tissue Inhibitor of Metalloproteinase-3 Are Overexpressed in the Wall of Abdominal Aortic Aneurysms
2002
Efficiency of translation initiation by non-AUG codons in Saccharomyces cerevisiae.
1988
Interferon-beta inhibits activated leukocyte migration through human brain microvascular endothelial cell monolayer.
1999
Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.
1991
Quantitation of matrix metalloproteinases in cultured rat astrocytes using the polymerase chain reaction with a multi-competitor cDNA standard
1996