Standout Papers
Citation Impact
Citing Papers
Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody
2016 Standout
Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors
2017
A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
2018 Science
Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T-cell Response against Immunosuppressive Tumors
2019
A method for integrative structure determination of protein-protein complexes
2012
Neuroplasticity – Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor
2010
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
2022 Standout
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
2014 Standout
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
2014
Optical coherence tomography angiography
2017 Standout
Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies
2017
Scoring functions for protein–protein interactions
2013 StandoutNobel
Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic Intervention
2016
Single particle electron cryo-microscopy of a mammalian ion channel
2014 StandoutNobel
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
Immunosuppression by human gangliosides
1992
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
2019 Standout
Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer
2017
Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection
2018 StandoutNobel
Understanding the tumor immune microenvironment (TIME) for effective therapy
2018 Standout
Morphological and Pathological Evolution of the Brain Microcirculation in Aging and Alzheimer’s Disease
2012
The immune contexture in cancer prognosis and treatment
2017 Standout
T Cell Dysfunction in Cancer
2018
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
2016 StandoutNobel
Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease
2014
Tau in physiology and pathology
2015 Standout
Delivery technologies for cancer immunotherapy
2019 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
2017 StandoutNobel
Inflammation and tumor progression: signaling pathways and targeted intervention
2021 Standout
The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
2013
Immunopathology of multiple sclerosis
2015 Standout
Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial
2018
Biological roles of oligosaccharides: all of the theories are correct
1993 Standout
Biomimetic biodegradable artificial antigen presenting cells synergize with PD-1 blockade to treat melanoma
2016
Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice
2019
Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations
2016
Age-related macular degeneration
2018 Standout
Geographic Atrophy
2014
Regulation and Function of the PD-L1 Checkpoint
2018 Standout
Fabs Enable Single Particle cryoEM Studies of Small Proteins
2012
Antibody Therapeutics Targeting Aβ and Tau
2017
The effects of acute exercise on cognitive performance: A meta-analysis
2012 Standout
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age‐Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults
2016 Standout
Melanocortin control of energy balance: evidence from rodent models
2011
NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer
2017
CAR-T cell therapy: current limitations and potential strategies
2021 Standout
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
2020 Standout
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
2017 StandoutNobel
Regulation of type I interferon responses
2013 Standout
Animal models of obesity and diabetes mellitus
2018
Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments
2009 Standout
From monoclonal antibodies to small molecules: the development of inhibitors targeting the PD-1/PD-L1 pathway
2016
High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer
2022
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
2019
A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice
2012
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
2020 Standout
PD-1 coinhibitory signals: The link between pathogenesis and protection
2013
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
2018 Standout
The Role of GITR/GITRL Interaction in Autoimmune Diseases
2020
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
2023 StandoutNobel
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
2017 Standout
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
2013
Associations Between Age-Related Macular Degeneration, Alzheimer Disease, and Dementia
2013
The neuropathological diagnosis of Alzheimer’s disease
2019 Standout
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Regulatory T Cells and Human Disease
2020 StandoutNobel
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity
2022 StandoutNobel
Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers
2016
Geographic Atrophy
2014
Diversity, Mechanisms, and Significance of Macrophage Plasticity
2019 Standout
Inflammation as a central mechanism in Alzheimer's disease
2018 Standout
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
2018 StandoutNobel
Age-Related Macular Degeneration (AMD): Alzheimer's Disease in the Eye?
2011
IL-7 Abrogates Suppressive Activity of Human CD4+CD25+FOXP3+ Regulatory T Cells and Allows Expansion of Alloreactive and Autoreactive T Cells
2012
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity
2017
Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex
2016 StandoutNobel
Chimeric Antigen Receptor Therapy
2018 Standout
TISIDB: an integrated repository portal for tumor–immune system interactions
2019 Standout
Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity
2015
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health
2020 Standout
Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration
2009
The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease
2018 Standout
Co-Stimulatory Receptors in Cancers and Their Implications for Cancer Immunotherapy
2020
Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations
2013
Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy
2015
Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti‐cancer antibodies: IUPHAR Review 18
2016
Works of John Lin being referenced
Characterization and Comparison of GITR Expression in Solid Tumors
2019 Nobel
Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model
2014
ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40–Mediated Tumor Rejection
2016 StandoutNobel
Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease
2011
Targeting age-related macular degeneration with Alzheimer’s disease based immunotherapies: Anti-amyloid-β antibody attenuates pathologies in an age-related macular degeneration mouse model
2007
Proprotein Convertase Substilisin/Kexin Type 9 Antagonism Reduces Low-Density Lipoprotein Cholesterol in Statin-Treated Hypercholesterolemic Nonhuman Primates
2011
Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates
2008
IL-7 Promotes T H 1 Development and Serum IL-7 Predicts Clinical Response to Interferon-β in Multiple Sclerosis
2011
Lectin- and ionophore-stimulated Ca2+ influx in murine lymphocytes: Inhibition by disialoganglioside
1983
Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
2012
39-Week Toxicity and Toxicokinetic Study of Ponezumab (PF-04360365) in Cynomolgus Monkeys with 12-Week Recovery Period
2012
TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice
2007
Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
2011