Standout Papers
- Defining the Inside and Outside of a Catalytic RNA Molecule (1989)
- A Novel Mutation in CD83 Results in the Development of a Unique Population of CD4+ T Cells (2004)
- Selection of single-stranded DNA molecules that bind and inhibit human thrombin (1992)
- Benzobicyclooctanes as novel inhibitors of TNF-α signaling (2002)
- Polymorphisms in the Sclerosteosis/van Buchem Disease Gene (SOST) Region Are Associated with Bone-Mineral Density in Elderly Whites (2004)
Citation Impact
Citing Papers
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription
2002 Standout
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene
2006 StandoutScienceNobel
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Modified DNA Aptamer That Binds the ( R )-Isomer of a Thalidomide Derivative with High Enantioselectivity
2007
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
Label-free optical detection of aptamer–protein interactions using gold-capped oxide nanostructures
2008
Proximity extension of circular DNA aptamers with real-time protein detection
2005
HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA
1991 StandoutNobel
Protein-dependent ribozymes report molecular interactions in real time
2002
The tertiary structure of a DNA aptamer which binds to and inhibits thrombin determines activity
1993
Effect of buffer, electric field, and separation time on detection of aptamer‐ligand complexes for affinity probe capillary electrophoresis
2003
Influence of DNA Aptamer Structure on the Specificity of Binding to Taq DNA Polymerase
2003
High-Resolution Molecular Discrimination by RNA
1994 Science
A three-dimensional perspective on exon binding by a group II self-splicing intron
2000
Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron
1990
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Isolation of a fluorophore-specific DNA aptamer with weak redox activity
1998 StandoutNobel
Construction, Stability, and Activity of Multivalent Circular Anticoagulant Aptamers
2004
Telomeres: No end in sight
1994 StandoutNobel
Quantum‐Dot Aptamer Beacons for the Detection of Proteins
2005
Aptamer structures from A to ζ
1996
The DNA aptamers that specifically recognize ricin toxin are selected by two in vitro selection methods
2006
Analysis of the role of phosphate oxygens in the group I intron from Tetrahymena
1992
Metal-binding sites in the major groove of a large ribozyme domain
1996 StandoutNobel
The efficiency and versatility of catalytic RNA: implications for an RNA world
1993
Modified RNA sequence pools forin vitroselection
1994
DNA aptamers and DNA enzymes
1997
Ribozyme-catalysed amino-acid transfer reactions
1996 StandoutNatureNobel
Potent 2'-Amino-2'-deoxypyrimidine RNA Inhibitors of Basic Fibroblast Growth Factor
1995
Self‐Cleaving Ribozymes of Hepatitis Delta Virus RNA
1997
A truncation in the 14 kDa protein of the signal recognition particle leads to tertiary structure changes in the RNA and abolishes the elongation arrest activity of the particle
1997
Asymmetric Disulfonimide‐Catalyzed Synthesis of δ‐Amino‐β‐Ketoester Derivatives by Vinylogous Mukaiyama–Mannich Reactions
2014 StandoutNobel
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids
2000
Functional proteins from a random-sequence library
2001 StandoutNatureNobel
Electronic Aptamer‐Based Sensors
2007
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
1997 StandoutNobel
Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis
1990
Oligonucleotide inhibitors of human thrombin that bind distinct epitopes
1997
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
2007
A DNA Aptamer That Binds Adenosine and ATP
1995 StandoutNobel
Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG)
1994
Visualizing the solvent-inaccessible core of a group II intron ribozyme
2001
Structural elements in the internal ribosome entry site of Plautia stali intestine virus responsible for binding with ribosomes
2003
Multitasking by Multivalent Circular DNA Aptamers
2006
Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns
1990 StandoutNatureNobel
Isolation of a local tertiary folding transition in the context of a globally folded RNA
1996
Reciprocal intronic and exonic histone modification regions in humans
2010
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
Sensitive detection of protein by an aptamer-based label-free fluorescing molecular switch
2006
Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity
2001
Catalytic activity is retained in theTetrahymenagroup I intron despite removal of the large extension of element P5
1989
Rules for RNA recognition of GNRA tetraloops deduced by invitro selection: comparison with invivo evolution
1997
Important 2'-hydroxyl groups within the core of a group I intron
1993
Bioassay of bile acids using an enzyme-linked DNA aptamer
2000
Specific binding of aminoglycoside antibiotics to RNA
1995
A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA
1993
New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme
1996
Monitoring complex formation in the blood-coagulation cascade using aptamer-coated SAW sensors
2004
Aptamer Beacons for the Direct Detection of Proteins
2001
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Engineering Allosteric Regulation into Biological Catalysts
2009
Selection of a Suppressor Mutation That Restores Affinity of an Oligonucleotide Inhibitor for Thrombin Using in Vitro Genetics
1995
Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
1999 StandoutNatureNobel
A DNA enzyme that cleaves RNA
1994
DNAzyme-based colorimetric sensing of lead (Pb2+) using unmodified gold nanoparticle probes
2008
Colorimetric Biosensors Based on DNAzyme-Assembled Gold Nanoparticles
2004
In vitro selection of DNA aptamers which bind to cholic acid
2000
Genetic complementation reveals a novel regulatory role for 3? untranslated regions in growth and differentiation
1993
Aptamer biosensor for protein detection using gold nanoparticles
2007
Deoxyribozymes: useful DNA catalysts in vitro and in vivo
2008
Aptamer therapeutics advance
2006
Isolation and characterization of fluorophore-binding RNA aptamers
1998 StandoutNobel
Peroxidase activity of in vitro‐selected 2′‐amino RNAs
2001
A Pyrene‐Labeled G‐Quadruplex Oligonucleotide as a Fluorescent Probe for Potassium Ion Detection in Biological Applications
2005
Aptamer Database
2003
In Vitro Selection of RNA Ligands to Substance P
1995
[20] In vitro selection of nucleic acid aptamers that bind proteins
1996
In vitro selection of self-cleaving DNAs
1996
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Evidence for processivity and two-step binding of the RNA substrate from studies of J1/2 mutants of the Tetrahymena ribozyme
1992
A DNA metalloenzyme with DNA ligase activity
1995 StandoutNatureNobel
Expanding the Catalytic Repertoire of Nucleic Acid Catalysts: Simultaneous Incorporation of Two Modified Deoxyribonucleoside Triphosphates Bearing Ammonium and Imidazolyl Functionalities
1999
Higher order folding and domain analysis of the ribozyme from Bacillus subtilis ribonuclease P
1995
Structure‐Switching Signaling Aptamers: Transducing Molecular Recognition into Fluorescence Signaling
2004
An enzyme-linked oligonucleotide assay
1996
RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme
1992 Nature
In vitro selection of RNA aptamers specific for cyanocobalamin
1994 StandoutNobel
Molecular Aptamer Beacons for Real-Time Protein Recognition
2002
Functional DNA nanotechnology: emerging applications of DNAzymes and aptamers
2006
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5′ splice site domain
1995 Nobel
Label‐Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer‐Based Sensor
2005 Nobel
In vitro evolution of a self-alkylatlng ribozyme
1995 StandoutNatureNobel
In vitro evolution of new ribozymes with polynucleotide kinase activity
1994 StandoutNatureNobel
Encapsulating an amino acid in a DNA fold
1996
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
DNA enzymes
1997
A Novel Class of Small Functional Peptides that Bind and Inhibit Human α-Thrombin Isolated by mRNA Display
2003
Production and processing of aptamer microarrays
2005
Emerging clinical applications of RNA
2002 Nature
Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor
1995
Photonic boolean logic gates based on DNA aptamers
2006
THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER
1993
PCR product with strands of unequal length
1995
Optical Sensors Based on Hybrid DNA/Conjugated Polymer Complexes
2004
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
The Hepatitis C Virus Internal Ribosome Entry Site Adopts an Ion-dependent Tertiary Fold
1999 StandoutNobel
Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms
1990 Nobel
Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX
2004
Crystal structure of a hepatitis delta virus ribozyme
1998 StandoutNatureNobel
Structurally Complex and Highly Active RNA Ligases Derived from Random RNA Sequences
1995 StandoutScienceNobel
Structure, recognition and adaptive binding in RNA aptamer complexes
1997
Aptamer-based biosensor arrays for detection and quantification of biological macromolecules
2003
High-affinity RNA ligands to human α-thrombin
1994
Mechanism of ribosome recruitment by hepatitis C IRES RNA
2001 StandoutNobel
An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme
1993
A combined atomic force/fluorescence microscopy technique to select aptamers in a single cycle from a small pool of random oligonucleotides
2007
Characterization and divalent metal-ion dependence of in vitro selected deoxyribozymes which cleave DNA/RNA chimeric oligonucleotides
1997
Nucleic Acid-Binding Properties of the Xenopus Oocyte Y Box Protein mRNP3+4
1994
In vitro evolution of nucleic acids
1994
Novel electrochemical sensor system for protein using the aptamers in sandwich manner
2004
Immunofluorescence assay and flow-cytometry selection of bead-bound aptamers
2003
A Single-Molecule Study of RNA Catalysis and Folding
2000 ScienceNobel
Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition.
1995
Fishing for fresh catalysts
1993 NatureNobel
The single-stranded DNA aptamer-binding site of human thrombin.
1993
2014
Aptamers: An Emerging Class of Therapeutics
2005
Immobilized DNA Switches as Electronic Sensors for Picomolar Detection of Plasma Proteins
2008
A Novel, Modification-Dependent ATP-Binding Aptamer Selected from an RNA Library Incorporating a Cationic Functionality
2003 StandoutNobel
Coaxially Stacked RNA Helices in the Catalytic Center of the Tetrahymena Ribozyme
1994 ScienceNobel
Functional Nucleic Acid Sensors
2009 Standout
Quantitative Analysis of Receptors for Adenosine Nucleotides Obtained via In Vitro Selection from a Library Incorporating a Cationic Nucleotide Analog
1999
Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics
1999 Standout
Identification of two novel arginine binding DNAs.
1995
MECHANISTIC ASPECTS OF ENZYMATIC CATALYSIS: Lessons from Comparison of RNA and Protein Enzymes
1997
Nucleic Acid Selection and the Challenge of Combinatorial Chemistry
1997
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
Inhibition of multiple thermostable DNA polymerases by a heterodimeric aptamer
1997
Optical Detection of DNA and Proteins with Cationic Polythiophenes
2008
Visualizing the Higher Order Folding of a Catalytic RNA Molecule
1991 ScienceNobel
Spectroscopic studies of YO and YOYO fluorescent dyes in a thrombin-binding DNA ligand
1998
Different strategies to develop an electrochemical thrombin aptasensor
2006
A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.
1989 StandoutNobel
Exploring the folding landscape of a structured RNA
2001 Nobel
Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.
1994
MRI Detection of Thrombin with Aptamer Functionalized Superparamagnetic Iron Oxide Nanoparticles
2008
Chemical Glycobiology
2001 StandoutScienceNobel
An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site
1999
Two major tertiary folding transitions of the Tetrahymena catalytic RNA.
1994 Nobel
Catalytic Transformation of Lignin for the Production of Chemicals and Fuels
2015 Standout
Movement of the Guide Sequence During RNA Catalysis by a Group I Ribozyme
1993 ScienceNobel
An Aptamer‐Based Protein Biosensor by Detecting the Amplified Impedance Signal
2006
Randomization of genes by PCR mutagenesis.
1992
Immunomagnetic DNA Aptamer Assay
2001
Ribozyme catalysis
1992 StandoutNobel
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Crystallization of ribozymes and small RNA motifs by a sparse matrix approach.
1993 StandoutNobel
Aptamer-Based Electrochemical Sensors with Aptamer−Complementary DNA Oligonucleotides as Probe
2008
A Multisubunit Ribozyme That Is a Catalyst of and Template for Complementary Strand RNA synthesis
1991 StandoutScienceNobel
Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.
1991
Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core.
1991 Nobel
In Vitro Selection of Specific Ligand‐binding Nucleic Acids
1992 StandoutNobel
A Love-wave biosensor using nucleic acids as ligands
2004
Protein Detecting Arrays Based on Cationic Polythiophene–DNA‐Aptamer Complexes
2006
Ribozymes: A Distinct Class of Metalloenzymes
1993 Science
Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.
1993
Isolation of RNA Aptamers for Biological Cofactors by In Vitro Selection
1994
A Photochemical Strategy for Lignin Degradation at Room Temperature
2013
Adaptive Recognition by Nucleic Acid Aptamers
2000 Science
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
2007
Reconstitution of a group I intron self-splicing reaction with an activator RNA.
1991
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
Ribozyme Structures and Mechanisms
2000 StandoutNobel
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.
1993
In Vitro Selection of Functional Nucleic Acids
1999 StandoutNobel
Electrochemical Detection of Protein Using a Double Aptamer Sandwich
2004
Tertiary Structure Around the Guanosine-Binding Site of the Tetrahymena Ribozyme
1992 ScienceNobel
Aptamer-Enhanced Laser Desorption/Ionization for Affinity Mass Spectrometry
2004
Frequent use of the same tertiary motif by self-folding RNAs.
1995
Ribozyme Structures and Mechanisms
2001 StandoutNobel
The P5abc Peripheral Element Facilitates Preorganization of the Tetrahymena Group I Ribozyme for Catalysis
2000 StandoutNobel
Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy
2016 StandoutNobel
Combinatorial Selection and Edited Combinatorial Selection of Phosphorothioate Aptamers Targeting Human Nuclear Factor-κB RelA/p50 and RelA/RelA
2004
C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products
2018
Label-free protein recognition using an aptamer-based impedance measurement assay
2005
Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library
1996 Science
Insulin Capture by an Insulin-Linked Polymorphic Region G-Quadruplex DNA Oligonucleotide
2006
Optical Sensors Based on Hybrid Aptamer/Conjugated Polymer Complexes
2004
Bioactive and nuclease-resistant l -DNA ligand of vasopressin
1997
In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits
1993
Selection of a Ribozyme That Functions as a Superior Template in a Self-Copying Reaction
1992 StandoutScienceNobel
A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity
1995
Structural and Functional Characterization of Potent Antithrombotic Oligonucleotides Possessing Both Quadruplex and Duplex Motifs
1995
RNA Folding at Millisecond Intervals by Synchrotron Hydroxyl Radical Footprinting
1998 Science
A Detailed View of a Ribosomal Active Site
1999 StandoutNobel
Mirror-image RNA that binds D-adenosine
1996
Structural Insights into Group II Intron Catalysis and Branch-Site Selection
2002 StandoutScienceNobel
Works of John Latham being referenced
Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD
2016
The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing -(1 -pentynyl)-2′-deoxyuridine
1994
Cross-regulation of histone modifications
2007
PqqD Is a Novel Peptide Chaperone That Forms a Ternary Complex with the Radical S-Adenosylmethionine Protein PqqE in the Pyrroloquinoline Quinone Biosynthetic Pathway
2015
Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins
2004
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
1992 StandoutNature
Defining the Inside and Outside of a Catalytic RNA Molecule
1989 StandoutScienceNobel
Effects of Alkoxy Groups on Arene Rings of Lignin β-O-4 Model Compounds on the Efficiencies of Single Electron Transfer-Promoted Photochemical and Enzymatic C–C Bond Cleavage Reactions
2013
X-ray and EPR Characterization of the Auxiliary Fe–S Clusters in the Radical SAM Enzyme PqqE
2018
Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence
1990 Nobel
Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone
2017
Allylic and propargylic phenyl selenide oxygenation by cyclohexanone oxygenase: [2,3]-sigmatraopic rearrangement of the enzyme-generated selenoxide
1986
Regioselectivity of Enzymatic and Photochemical Single Electron Transfer Promoted Carbon−Carbon Bond Fragmentation Reactions of Tetrameric Lignin Model Compounds
2011