John Koerner

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

Antioxidant and Prooxidant Behavior of Flavonoids: Structure-Activity Relationships

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Cell Biology of Ischemia/Reperfusion Injury

Nitric Oxide and Peroxynitrite in Health and Disease

A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

Measuring reactive species and oxidative damagein vivoand in cell culture: how should you do it and what do the results mean?

Regulation of Coronary Blood Flow During Exercise

The inflammatory response in myocardial infarction

Inhibition of lipid peroxidation promoted by iron(III) and ascorbate

In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes

Myocardial Reperfusion Injury

Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.

Protection Against Reperfusion-Induced Arrhythmias by Human Thioredoxin

Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress

Assessing the proarrhythmic potential of drugs: Current status of models and surrogate parameters of torsades de pointes arrhythmias

Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options

Extracellular DNA traps promote thrombosis

Comparisons of ESR and HPLC methods for the detection of OH. radicals in ischemic/reperfused hearts

Antioxidant Capacity of Tea and Common Vegetables

Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting

Estrogen diminishes postischemic hydroxyl radical production

Myocardial Fatty Acid Metabolism in Health and Disease

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Molecular and Cellular Mechanisms of Myocardial Stunning

Free Radicals in the Physiological Control of Cell Function

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

Use of aromatic hydroxylation of phenylalanine to measure production of hydroxyl radicals after myocardial ischemia in vivo. Direct evidence for a pathogenetic role of the hydroxyl radical in myocardial stunning.

Probucol Reduces Myocardial Dysfunction During Reperfusion After Short-Term Ischemia in Rabbit Heart

Protection Against Postischemic Myocardial Dysfunction in Anesthetized Rabbits with Scavengers of Oxygen-Derived Free Radicals

Comparative Evaluation of HERG Currents and QT Intervals following Challenge with Suspected Torsadogenic and Nontorsadogenic Drugs

Delay of Occurrence of Reperfusion-Induced Ventricular Fibrillation in the Isolated Rat Heart with Superoxide Dismutase

Effect of physical training on coronary collateral circulation of the rat

Coronary blood flow in physically trained rats