Citation Impact
Citing Papers
A BOILED‐Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules
2016 Standout
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).
2009
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Mass spectrometry‐based metabolomics
2006 Standout
Methods for Predicting Human Drug Metabolism
2006
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
2006 Standout
Self-assembly of biotinylated poly(ethylene glycol)-poly(curcumin) for paclitaxel delivery
2018
Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay
2016
Simultaneous development of six LC–MS–MS methods for the determination of multiple analytes in human plasma
2002
Species differences in drug transporters and implications for translating preclinical findings to humans
2012
Liquid chromatography/tandem mass spectrometric bioanalysis using normal‐phase columns with aqueous/organic mobile phases – a novel approach of eliminating evaporation and reconstitution steps in 96‐well SPE
2002
VMN/LHA Functional Inhibition in Tumor-bearing Rats Suggests Hypothalamic Involvement in Cancer Anorexia
2002
Validation of new methods
2006 Standout
Quantitative high‐throughput analysis of drugs in biological matrices by mass spectrometry
2003
Liquid/liquid extraction using 96-well plate format in conjunction with hydrophilic interaction liquid chromatography–tandem mass spectrometry method for the analysis of fluconazole in human plasma
2003
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
Use of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary Transport
2006
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
2020 StandoutNobel
Cancer-associated cachexia
2018 Standout
Hydrophilic interaction chromatography
2006 Standout
Profiling drug-like properties in discovery research
2003
Development, maintenance and disruption of the blood-brain barrier
2013 Standout
Natural product-based nanoformulations for cancer therapy: Opportunities and challenges
2019 Standout
Coexistence of passive and carrier-mediated processes in drug transport
2010
New Perspectives on Innovative Drug Discovery: An Overview
2010
Automated 96-well solid phase extraction and hydrophilic interaction liquid chromatography–tandem mass spectrometric method for the analysis of cetirizine (ZYRTEC®) in human plasma—with emphasis on method ruggedness
2004
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
2019
The use of spirocyclic scaffolds in drug discovery
2014 Standout
Effects of omega-3 fatty acids on orexigenic and anorexigenic modulators at the onset of anorexia
2005
Potential therapeutic targets for neurokinin-1 receptor antagonists
2004
The neural basis of psychedelic action
2022 Standout
A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry–Based Glycoproteomics
2020 StandoutNobel
A Single-Dose Study to Assess the Penetration of Stavudine Into Human Cerebrospinal Fluid in Adults
1998
Quantitation of small molecules using high‐resolution accurate mass spectrometers – a different approach for analysis of biological samples
2009
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
In vitro and pharmacophore insights into CYP3A enzymes
2003
Asymmetric Multicomponent Reactions (AMCRs): The New Frontier
2005 Standout
An analysis of the attrition of drug candidates from four major pharmaceutical companies
2015 Standout
Global metabolic profiling procedures for urine using UPLC–MS
2010 Standout
Glycoproteomics
2022 StandoutNobel
Method development in high-performance liquid chromatography for high-throughput profiling and metabonomic studies of biofluid samples
2003
Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources
2014 Standout
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
Potential therapeutic targets for neurokinin-1 receptor antagonists
2004
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Rapid and Deep Profiling of Human Induced Pluripotent Stem Cell Proteome by One-shot NanoLC–MS/MS Analysis with Meter-scale Monolithic Silica Columns
2012 StandoutNobel
admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties
2012 Standout
Mass Spectrometry
1998
Oxadiazoles in Medicinal Chemistry
2011 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Electrospray mass spectrometry of fossil fuels
2000 StandoutNobel
Improving the Odds of Success in Drug Discovery: Choosing the Best Compounds for in Vivo Toxicology Studies
2013
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
2013 Standout
Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design
2012
Trifluoromethyl Oxetanes: Synthesis and Evaluation as a tert‐Butyl Isostere
2017
Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors
2012
Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections
2010 Standout
A Novel Approach for Predicting P-Glycoprotein (ABCB1) Inhibition Using Molecular Interaction Fields
2011
Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds
2012
Automated 20 kpsi RPLC-MS and MS/MS with Chromatographic Peak Capacities of 1000−1500 and Capabilities in Proteomics and Metabolomics
2005
Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
2010
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability
2016
CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure
2014
Fine adjustment of gas modifier loadings for separation of epimeric glycopeptides using differential ion mobility spectrometry mass spectrometry
2020
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Predicting Efflux Ratios and Blood-Brain Barrier Penetration from Chemical Structure: Combining Passive Permeability with Active Efflux by P-Glycoprotein
2012
Analyzing Glycopeptide Isomers by Combining Differential Mobility Spectrometry with Electron- and Collision-Based Tandem Mass Spectrometry
2017
A Medicinal Chemist’s Guide to Molecular Interactions
2010 Standout
Works of John Janiszewski being referenced
A centralized approach to tandem mass spectrometry method development for high‐throughput ADME screening
2006
Automated sample preparation using membrane microtiter extraction for bioanalytical mass spectrometry
1997
In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System
2007
Assay of ezlopitant, a substance P receptor antagonist, and metabolites in biological matrices by gas chromatography with mass spectrometric detection: simultaneous analysis of a benzyl alcohol and alkene
2000
Amino acid profiles in tumor-bearing and pair-fed nontumor-bearing malnourished rats
1988
Optimizing Higher Throughput Methods to Assess Drug–Drug Interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 In Vitro Using a Single Point IC50
2002
High-performance liquid chromatographic determination of 2′,3′-didehydro-3′-deoxythymidine, a new anti-human immunodeficiency virus agent, in human plasma and urine
1992
AutoScan: an automated workstation for rapid determination of mass and tandem mass spectrometry conditions for quantitative bioanalytical mass spectrometry
2000
Perspectives on Bioanalytical Mass Spectrometry and Automation in Drug Discovery
2008
Determining molecular properties with differential mobility spectrometry and machine learning
2018
High-Throughput Method Development Approaches for Bioanalytical Mass Spectrometry
2000
Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry
2017
Using differential mobility spectrometry to measure ion solvation: an examination of the roles of solvents and ionic structures in separating quinoline-based drugs
2015
A High-Capacity LC/MS System for the Bioanalysis of Samples Generated from Plate-Based Metabolic Screening
2001