Standout Papers
Citation Impact
Citing Papers
Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies
2008 Standout
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription
2002 Standout
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene
2006 StandoutScienceNobel
Modified DNA Aptamer That Binds the ( R )-Isomer of a Thalidomide Derivative with High Enantioselectivity
2007
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
The Effect of Lopinavir/Ritonavir on the Renal Clearance of Tenofovir in HIV-infected Patients
2007
Label-free optical detection of aptamer–protein interactions using gold-capped oxide nanostructures
2008
Proximity extension of circular DNA aptamers with real-time protein detection
2005
Protein-dependent ribozymes report molecular interactions in real time
2002
The tertiary structure of a DNA aptamer which binds to and inhibits thrombin determines activity
1993
Effect of buffer, electric field, and separation time on detection of aptamer‐ligand complexes for affinity probe capillary electrophoresis
2003
Influence of DNA Aptamer Structure on the Specificity of Binding to Taq DNA Polymerase
2003
High-Resolution Molecular Discrimination by RNA
1994 Science
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
1991 Standout
Gemini: A Noninferiority Study of Saquinavir/Ritonavir Versus Lopinavir/Ritonavir as Initial HIV-1 Therapy in Adults
2009
Isolation of a fluorophore-specific DNA aptamer with weak redox activity
1998 StandoutNobel
Construction, Stability, and Activity of Multivalent Circular Anticoagulant Aptamers
2004
Quantum‐Dot Aptamer Beacons for the Detection of Proteins
2005
Aptamer structures from A to ζ
1996
The DNA aptamers that specifically recognize ricin toxin are selected by two in vitro selection methods
2006
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
2007
The efficiency and versatility of catalytic RNA: implications for an RNA world
1993
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Modified RNA sequence pools forin vitroselection
1994
DNA aptamers and DNA enzymes
1997
Ribozyme-catalysed amino-acid transfer reactions
1996 StandoutNatureNobel
Potent 2'-Amino-2'-deoxypyrimidine RNA Inhibitors of Basic Fibroblast Growth Factor
1995
Factors Associated with the Emergence of K65R in Patients with HIV‐1 Infection Treated with Combination Antiretroviral Therapy Containing Tenofovir
2008
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids
2000
Functional proteins from a random-sequence library
2001 StandoutNatureNobel
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats
1987
Anandamide and vanilloid TRPV1 receptors
2003
Electronic Aptamer‐Based Sensors
2007
Greater Tenofovir‐Associated Renal Function Decline with Protease Inhibitor–Based versus Nonnucleoside Reverse‐Transcriptase Inhibitor–Based Therapy
2007
Sequence similarity of phospholipase C with the non-catalytic region of src
1988 Nature
Oligonucleotide inhibitors of human thrombin that bind distinct epitopes
1997
A DNA Aptamer That Binds Adenosine and ATP
1995 StandoutNobel
Multitasking by Multivalent Circular DNA Aptamers
2006
The CpG dinucleotide and human genetic disease
1988
Expression monitoring by hybridization to high-density oligonucleotide arrays
1996 Standout
The molecular basis of blood coagulation
1988 Standout
A chemistry of mammalian pheromones
1991
Sensitive detection of protein by an aptamer-based label-free fluorescing molecular switch
2006
Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity
2001
Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment
2009
Better Adherence with Once‐Daily Antiretroviral Regimens: A Meta‐Analysis
2009
Abacavir–Lamivudine versus Tenofovir–Emtricitabine for Initial HIV-1 Therapy
2009
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Bioassay of bile acids using an enzyme-linked DNA aptamer
2000
Specific binding of aminoglycoside antibiotics to RNA
1995
A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA
1993
Monitoring complex formation in the blood-coagulation cascade using aptamer-coated SAW sensors
2004
Aptamer Beacons for the Direct Detection of Proteins
2001
Engineering Allosteric Regulation into Biological Catalysts
2009
Selection of a Suppressor Mutation That Restores Affinity of an Oligonucleotide Inhibitor for Thrombin Using in Vitro Genetics
1995
A DNA enzyme that cleaves RNA
1994
Treatment for Adult HIV Infection
2006
DNAzyme-based colorimetric sensing of lead (Pb2+) using unmodified gold nanoparticle probes
2008
Should we now adopt the HIV-RNA < 50 copy endpoint for clinical trials of antiretroviral-experienced as well as naive patients?
2007
Colorimetric Biosensors Based on DNAzyme-Assembled Gold Nanoparticles
2004
In vitro selection of DNA aptamers which bind to cholic acid
2000
High Rate of Virologic Suppression with Raltegravir plus Etravirine and Darunavir/Ritonavir among Treatment‐Experienced Patients Infected with Multidrug‐Resistant HIV: Results of the ANRS 139 TRIO Trial
2009
The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial
2006
Aptamer biosensor for protein detection using gold nanoparticles
2007
Deoxyribozymes: useful DNA catalysts in vitro and in vivo
2008
Aptamer therapeutics advance
2006
Isolation and characterization of fluorophore-binding RNA aptamers
1998 StandoutNobel
Peroxidase activity of in vitro‐selected 2′‐amino RNAs
2001
A Pyrene‐Labeled G‐Quadruplex Oligonucleotide as a Fluorescent Probe for Potassium Ion Detection in Biological Applications
2005
Aptamer Database
2003
In Vitro Selection of RNA Ligands to Substance P
1995
[20] In vitro selection of nucleic acid aptamers that bind proteins
1996
In vitro selection of self-cleaving DNAs
1996
A DNA metalloenzyme with DNA ligase activity
1995 StandoutNatureNobel
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
Expanding the Catalytic Repertoire of Nucleic Acid Catalysts: Simultaneous Incorporation of Two Modified Deoxyribonucleoside Triphosphates Bearing Ammonium and Imidazolyl Functionalities
1999
Renal function with use of a tenofovir-containing initial antiretroviral regimen
2009
Structure‐Switching Signaling Aptamers: Transducing Molecular Recognition into Fluorescence Signaling
2004
An enzyme-linked oligonucleotide assay
1996
In vitro selection of RNA aptamers specific for cyanocobalamin
1994 StandoutNobel
Molecular Aptamer Beacons for Real-Time Protein Recognition
2002
Functional DNA nanotechnology: emerging applications of DNAzymes and aptamers
2006
The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years
2007
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis
2009
Label‐Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer‐Based Sensor
2005 Nobel
In vitro evolution of a self-alkylatlng ribozyme
1995 StandoutNatureNobel
Long-Term Body Fat Outcomes in Antiretroviral-Naive Participants Randomized to Nelfinavir or Efavirenz or Both Plus Dual Nucleosides
2007
In vitro evolution of new ribozymes with polynucleotide kinase activity
1994 StandoutNatureNobel
A novel family of genes encoding putative pheromone receptors in mammals
1995 StandoutNobel
Encapsulating an amino acid in a DNA fold
1996
The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic
2006
DNA enzymes
1997
A Novel Class of Small Functional Peptides that Bind and Inhibit Human α-Thrombin Isolated by mRNA Display
2003
Production and processing of aptamer microarrays
2005
Emerging clinical applications of RNA
2002 Nature
Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor
1995
Photonic boolean logic gates based on DNA aptamers
2006
THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER
1993
PCR product with strands of unequal length
1995
Optical Sensors Based on Hybrid DNA/Conjugated Polymer Complexes
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX
2004
Structurally Complex and Highly Active RNA Ligases Derived from Random RNA Sequences
1995 StandoutScienceNobel
Structure, recognition and adaptive binding in RNA aptamer complexes
1997
Aptamer-based biosensor arrays for detection and quantification of biological macromolecules
2003
Antiretroviral Treatment of Adult HIV Infection
2012 Standout
High-affinity RNA ligands to human α-thrombin
1994
A combined atomic force/fluorescence microscopy technique to select aptamers in a single cycle from a small pool of random oligonucleotides
2007
Characterization and divalent metal-ion dependence of in vitro selected deoxyribozymes which cleave DNA/RNA chimeric oligonucleotides
1997
In vitro evolution of nucleic acids
1994
Novel electrochemical sensor system for protein using the aptamers in sandwich manner
2004
Immunofluorescence assay and flow-cytometry selection of bead-bound aptamers
2003
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
1983 Nature
Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition.
1995
Fishing for fresh catalysts
1993 NatureNobel
The single-stranded DNA aptamer-binding site of human thrombin.
1993
Aptamers: An Emerging Class of Therapeutics
2005
Homologies Between Signal Transducing G Proteins and ras Gene Products
1984 StandoutScienceNobel
Cellular Oncogenes and Multistep Carcinogenesis
1983 Science
Immobilized DNA Switches as Electronic Sensors for Picomolar Detection of Plasma Proteins
2008
A Novel, Modification-Dependent ATP-Binding Aptamer Selected from an RNA Library Incorporating a Cationic Functionality
2003 StandoutNobel
Design Issues in Initial HIV-Treatment Trials: Focus on Actg A5095
2006
Functional Nucleic Acid Sensors
2009 Standout
Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma.
1984
Quantitative Analysis of Receptors for Adenosine Nucleotides Obtained via In Vitro Selection from a Library Incorporating a Cationic Nucleotide Analog
1999
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics
1999 Standout
Identification of two novel arginine binding DNAs.
1995
Nucleic Acid Selection and the Challenge of Combinatorial Chemistry
1997
Subfamilies of the mouse major urinary protein (MUP) multi-gene family: sequence analysis of cDNA clones and differential regulation in the liver
1984
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene
1983 Nature
Inhibition of multiple thermostable DNA polymerases by a heterodimeric aptamer
1997
Optical Detection of DNA and Proteins with Cationic Polythiophenes
2008
Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.
1987
Spectroscopic studies of YO and YOYO fluorescent dyes in a thrombin-binding DNA ligand
1998
Different strategies to develop an electrochemical thrombin aptasensor
2006
Complete cDNA and derived amino acid sequence of human factor V.
1987
Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.
1994
Identification of a Missense Mutation in the Factor VIII Gene of a Mild Hemophiliac
1986 Science
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
MRI Detection of Thrombin with Aptamer Functionalized Superparamagnetic Iron Oxide Nanoparticles
2008
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
1984 StandoutScienceNobel
Tγ protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer
1987 StandoutNatureNobel
Chemical Glycobiology
2001 StandoutScienceNobel
Biological properties of human c-Ha-ras1 genes mutated at codon 12
1984 Nature
Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots
1986 Nature
Human genes encoding prothrombin and ceruloplasmin map to 11p11?q12 and 3q21?24, respectively
1987
The Chromosomal Basis of Human Neoplasia
1983 Science
Characterization of a cDNA coding for human factor VII.
1986
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
The N-rasoncogene assigned to the short arm of human chromosome 1
1983
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes.
1986
Ultrasensitive Detection of Protein Using an Aptamer-Based Exonuclease Protection Assay
2004
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Characterization of five partial deletions of the factor VIII gene.
1987
An Aptamer‐Based Protein Biosensor by Detecting the Amplified Impedance Signal
2006
Randomization of genes by PCR mutagenesis.
1992
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc
1984 StandoutNatureNobel
Immunomagnetic DNA Aptamer Assay
2001
Aptamer-Based Electrochemical Sensors with Aptamer−Complementary DNA Oligonucleotides as Probe
2008
HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic review
2009
Distribution of factor VIII mRNA and antigen in human liver and other tissues
1985 Nature
A Love-wave biosensor using nucleic acids as ligands
2004
Protein Detecting Arrays Based on Cationic Polythiophene–DNA‐Aptamer Complexes
2006
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Novel Regulators of Bone Formation: Molecular Clones and Activities
1988 StandoutScience
Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin.
1986
Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.
1993
Isolation of RNA Aptamers for Biological Cofactors by In Vitro Selection
1994
Cloning and expression of multiple protein kinase C cDNAs
1986
Expression of completely gamma-carboxylated recombinant human prothrombin.
1987
Adaptive Recognition by Nucleic Acid Aptamers
2000 Science
Gene deletions correlate with the development of alloantibodies in von Willebrand disease.
1987
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
2007
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.
1993
In Vitro Selection of Functional Nucleic Acids
1999 StandoutNobel
Electrochemical Detection of Protein Using a Double Aptamer Sandwich
2004
A cellular gene encodes scrapie PrP 27-30 protein
1985 StandoutNobel
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Aptamer-Enhanced Laser Desorption/Ionization for Affinity Mass Spectrometry
2004
Isolation and characterization of genomic and cDNA clones of human erythropoietin
1985 Nature
Risk of Myocardial Infarction in Patients with HIV Infection Exposed to Specific Individual Antiretroviral Drugs from the 3 Major Drug Classes: The Data Collection on Adverse Events of Anti‐HIV Drugs (D:A:D) Study
2009
Combinatorial Selection and Edited Combinatorial Selection of Phosphorothioate Aptamers Targeting Human Nuclear Factor-κB RelA/p50 and RelA/RelA
2004
A functional γ gene formed from known γ-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes
1986 StandoutNatureNobel
Uncompensated polyuria in a mouse model of Bartter's syndrome
2000 StandoutNobel
Label-free protein recognition using an aptamer-based impedance measurement assay
2005
Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library
1996 Science
The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors
1983
Insulin Capture by an Insulin-Linked Polymorphic Region G-Quadruplex DNA Oligonucleotide
2006
Optical Sensors Based on Hybrid Aptamer/Conjugated Polymer Complexes
2004
Bioactive and nuclease-resistant l -DNA ligand of vasopressin
1997
In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits
1993
A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.
1986
A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity
1995
Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule
1986
Structural and Functional Characterization of Potent Antithrombotic Oligonucleotides Possessing Both Quadruplex and Duplex Motifs
1995
Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21
1984
Mirror-image RNA that binds D-adenosine
1996
The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions
1984
Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization
1985 Science
In vitro synthesis and characterization of precursors to the mouse major urinary proteins.
1980
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
1985 StandoutNatureNobel
Works of John J. Toole being referenced
Tenofovir Disoproxil Fumarate, Emtricitabine, and Efavirenz Versus Fixed-Dose Zidovudine/Lamivudine and Efavirenz in Antiretroviral-Naive Patients
2006
Pharmacological Characterization of the Anandamide Cyclooxygenase Metabolite: Prostaglandin E2 Ethanolamide
2002
The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing -(1 -pentynyl)-2′-deoxyuridine
1994
Tenofovir DF, Emtricitabine, and Efavirenz vs. Zidovudine, Lamivudine, and Efavirenz for HIV
2006
Tenofovir Disoproxil Fumarate, Emtricitabine, and Efavirenz Compared With Zidovudine/Lamivudine and Efavirenz in Treatment-Naive Patients
2008
The discovery and characterization of a novel nucleotide-based thrombin inhibitor
1993
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
1992 StandoutNature
Multiple genes coding for the androgen-regulated major urinary proteins of the mouse
1979
Tenofovir Disoproxil Fumarate in Nucleoside-Resistant HIV-1 Infection
2003
Molecular cloning of a cDNA encoding human antihaemophilic factor
1984 Nature
Characterization of a human colon/lung carcinoma oncogene
1983 Nature
PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS
1985
Human c-Ki- ras 2 Proto-Oncogene on Chromosome 12
1983 Science
Hemophilia A
1985
An abundant androgen-regulated mRNA in the mouse kidney
1979