Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila
1995 Science
Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal
2001 Science
Sonic hedgehogin feather morphogenesis: Induction of mesenchymal condensation and association with cell death
1996
Growth and differentiation in the Drosophila eye coordinated by hedgehog
1995 Nature
Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1
2001
The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides
2001
Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells
1999
Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
1995
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
1995 Standout
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
2000 Standout
Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
1995
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
1997 Nobel
Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan
1999
Somite Differentiation: Sonic signals somites
1995
Hedgehog and Patched in Neural Development and Disease
1998
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
2000 Standout
The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
1999 Nature
Sertoli cell signaling by Desert hedgehog regulates the male germline
1996
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage
1995
Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis
2001
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
1998 Nature
Patterning of the embryonic forebrain
1998
Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus
1999
An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development
2001
The long and short of hedgehog signaling
1995
Sinistral Snails and Gentlemen Scientists
2005 StandoutNobel
Modulation of Hedgehog target gene expression by the Fused serine–threonine kinase in wing imaginal discs
1998
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
1996 StandoutNature
The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina
1993
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
2003
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
1995
wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
1992
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish
1996 Nature
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia
2013
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
1994
Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
1995
Biochemical evidence that Patched is the Hedgehog receptor
1996 StandoutNature
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
2000
Hedgehog Signal Transduction in the Posterior Compartment of the Drosophila Wing Imaginal Disc
2000
A freely diffusible form of Sonic hedgehog mediates long-range signalling
2001 Nature
Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo
1993 Nature
Left–right asymmetry in embryonic development: a comprehensive review
2004
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
1994
Vertebrate Homologs of Drosophila Suppressor of Fused Interact with the Gli Family of Transcriptional Regulators
1999
Pancreatic Adenocarcinoma
2014 Standout
Analysis of Epithelial–Mesenchymal Interactions in the Initial Morphogenesis of the Mammalian Tooth
1998
Hedgehog, the floor plate, and the zone of polarizing activity
1994
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2
2003
The role of the notochord and floor plate in inductive interactions
1995
Autocatalytic Cleavage of the EMR2 Receptor Occurs at a Conserved G Protein-coupled Receptor Proteolytic Site Motif
2004
The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal
1996
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
1994 Standout
Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells
2004
Distinct pathways for autocrine and paracrine Wingless signalling inDrosophila embryos
1994 Nature
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
1993
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog
1997
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
New players and puzzles in the Hedgehog signaling pathway
1998
Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression
1999
Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
2001
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain
1996
Transducing Hedgehog: the story so far
1998
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Cytonemes
1999
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
2001 StandoutNobel
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1
1997
A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog
1995 Nature
The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog
1999
Induction of midbrain dopaminergic neurons by Sonic hedgehog
1995
Drosophila Clock Can Generate Ectopic Circadian Clocks
2003 StandoutNobel
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
1996 Standout
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
1995
Expression of the Sonic hedgehog (SHH) Gene during Early Human Development and Phenotypic Expression of New Mutations Causing Holoprosencephaly
1999
Hedgehog, Transmitted along Retinal Axons, Triggers Neurogenesis in the Developing Visual Centers of the Drosophila Brain
1996
Function for Hedgehog Genes in Zebrafish Retinal Development
2000
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
1996 Nature
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously
1995 StandoutNobel
The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
1993
Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila
2001 StandoutNobel
Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein
1995
fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
1994 StandoutNobel
Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila
1995
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
1996 Standout
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
1993 Standout
Distinct and regulated activities of human Gli proteins in Drosophila
1999
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
1994
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
1999
Protein kinase A and hedgehog signaling in drosophila limb development
1995
Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog
1998 Standout
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
The patched gene in development and cancer
1998
Drosophila hedgehog acts as a morphogen in cellular patterning
1994
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Sonic hedgehog mediates the polarizing activity of the ZPA
1993 Standout
Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
1994 Nature
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1997
Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation
1997
Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity
1996
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
1995
Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.
1993 StandoutNobel
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
1996 Science
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
1998
Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen
1997
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila
2000
Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina
1997
Mechanisms of compartment formation: Evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila
1993
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein
1997
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP- N - acetylgalactosamine, and UDP-galactose
2001 StandoutNobel
The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity
2000
Structure and expression of Hedgehog, a Drosophila segment-polarity gene required for cell-cell communication
1993
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
1998 StandoutScience
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
1996
Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus
1996 Science
Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals
1999
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
1995
Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog
1995
Transparent Stretchable Self-Powered Patchable Sensor Platform with Ultrasensitive Recognition of Human Activities
2015
Midline signalling is required for Pax gene regulation and patterning of the eyes
1995
Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.
1994
Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
1995
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
1997
Morphogens, Compartments, and Pattern: Lessons from Drosophila?
1996
Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
2000
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
1998
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.
1995
Genetic analysis of hedgehog signalling in the Drosophila embryo
1993
Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice
2000 StandoutNobel
Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation
2000
Control of chick tectum territory along dorsoventral axis by Sonic hedgehog
2000
Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos
1994
Autoproteolysis in hedgehog protein biogenesis
1994 Science
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Neural Science
2000 StandoutNobel
The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
1999
A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
1997
Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human‐Activity Monitoringand Personal Healthcare
2016 Standout
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.
1994
The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis
1997
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
1998
The ubiquitin ligase Hyperplastic discs negatively regulateshedgehoganddecapentaplegicexpression by independent mechanisms
2002
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
1995
Molecular Genetics of Human Retinal Disease
1999
A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
1999
Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning
1997
Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal CellsIn Vitro
1997
Differential requirements of the Fused kinase for Hedgehog signalling in the Drosophila embryo
1999
Hedgehog signals regulate multiple aspects of gastrointestinal development
2000
hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila
1996
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
1995 Nature
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly
1998
A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro
1997
Stretchable, Transparent, Ultrasensitive, and Patchable Strain Sensor for Human–Machine Interfaces Comprising a Nanohybrid of Carbon Nanotubes and Conductive Elastomers
2015
Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos
1993 StandoutNobel
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
1999
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
1996
The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila
1994
Early Synaptic Defects intulp1−/−Mice
2009
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Regulation of patched by sonic hedgehog in the developing neural tube.
1996 Standout
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
1996 StandoutScience
Diversity and Pattern in the Developing Spinal Cord
1996 Science
Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene
1997 Science
The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll
1994
Products, genetic linkage and limb patterning activity of a murine hedgehog gene
1994
Recent Progress in Electronic Skin
2015
Morphogen gradient interpretation
2001 StandoutNatureNobel
An absolute requirement for Cubitus interruptus in Hedgehog signaling
2001
Phosphorylation of the fused protein kinase in response to signaling from hedgehog.
1996 Nobel
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
1999
Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
1995
Works of John J. Lee being referenced
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
1992
TULP1 mutation in two extended Dominican kindreds with autosomal recessive Retinitis pigmentosa
1998
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
1995 Nature
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
1995
A stretchable strain sensor based on a metal nanoparticle thin film for human motion detection
2014
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
2014