Standout Papers
Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
T‐cell fate
1998
CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells
2015
Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination
1997
A New Monoclonal Antibody Which Selectively Recognizes the Active Form of Src Tyrosine Kinase
1996
Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement
1995
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
Inflammation and cancer
2002 StandoutNature
The helix-loop-helix gene E2A is required for B cell formation
1994
The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses
1994
Immature Thymocytes Employ Distinct Signaling Pathways for Allelic Exclusion versus Differentiation and Expansion
1999
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Control points in early T-cell development
1993
The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching
1996
Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα
1997
MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span
1996
TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development
1997
Accessibility Control of V(D)J Recombination: Lessons from Gene Targeting
1998
Origin of Murine B Cell Lineages
1993
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells
2005
Selected comparison of immune and nervous system development
2001
The glycans of stem cells
2007
Regulatory T Cells
2000 StandoutNobel
Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling
2004 StandoutNobel
FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor
2000
An activated Ick transgene promotes thymocyte development in rag-1 mutant mice
1994 Nobel
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
1994
Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity
1998
Organoid Models and Applications in Biomedical Research
2015 Standout
Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions
2007
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes
2002
γδ T-cell development
1993 StandoutNobel
The Hallmarks of Cancer
2000 Standout
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Notch Activity Influences the αβ versus γδ T Cell Lineage Decision
1997
Virus infections in mice with targeted gene disruptions
1993 StandoutNobel
Thymic selection revisited: how essential is it?
2003
In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision
1995
Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation
2012
Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice
1997
Gene Switching and the Stability of Odorant Receptor Gene Choice
2004 StandoutNobel
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
The mechanisms of immune diversification and their disorders
2003
Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells
1999
Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development
1996
Developmentally Programmed Rearrangement of T Cell Receptor Vγ Genes Is Controlled by Sequences Immediately Upstream of the Vγ Genes
1998
HIF-1alpha is required for solid tumor formation and embryonic vascularization
1998
Unexpectedly late expression of intracellular CD3ϵ and TCR γδ proteins during adult thymus development
1999
The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression
1997
The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice
1994
Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice
1997
Helper T Cell Differentiation Is Controlled by the Cell Cycle
1998
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
2010 Standout
Positive selection of lymphocytes
1994
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
1993 StandoutNatureNobel
Cell-mediated cytotoxicity
1993 StandoutNobel
Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development
2002
Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997
1998
Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4–CD8–) thymocytes
1996 StandoutNobel
Self-Tolerance Checkpoints in B Lymphocyte Development
1995
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
1999
Failure of B-cell differentiation in mice lacking the transcription factor EBF
1995 Nature
Clonal selection and learning in the antibody system
1996 StandoutNature
Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells
1995 Nature
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
The role of short homology repeats and TdT in generation of the invariant γδ antigen receptor repertoire in the fetal thymus
1995 StandoutNobel
Intrathymic δ Selection Events in γδ Cell Development
1997
α β and γ δ T cells can share a late common precursor
1995
Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms
1995
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
IL-7 Receptor and VDJ Recombination: Trophic Versus Mechanistic Actions
1997
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α
1998 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
1993
Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
1995
Recent Advances in Understanding V(D)J Recombination
1997
Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
1998 Nature
DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway
2000
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
2005
Development and Selection of T Cells: Facts and Puzzles
1995
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
The Developmental Fate of T Cells Is Critically Influenced by TCRγδ Expression
1998
Selective Events in T Cell Development
1994
Peripheral tolerance of CD4 T cells following local activation in adolescent mice
1996
Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development
2001
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.
1993 Nobel
Heavy-chain directed B-cell maturation: continuous clonal selection beginning at the pre-B cell stage
1994
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.
1994 Nobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
T cell fate specification and αβ/γδ lineage commitment
2001
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
1994
Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules
1998
The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development
1999
Characterization of TCR Gene Rearrangements During Adult Murine T Cell Development
1999
The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.
1995
Crucial function of the pre‐T‐cell receptor (TCR) in TCRP selection, TCRβ allelic exclusion and αβ versus γδ lineage commitment
1998
Specific requirement for CD3ɛ in T cell development
1998
Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice
2000 StandoutNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora
2002 StandoutScienceNobel
CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis
1999 Nobel
Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes
1993 Science
Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins
1999
Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine
2002
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
1998 StandoutScience
Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.
1996
Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.
1994
Replacement of Pre-T Cell Receptor Signaling Functions by the CD4 Coreceptor
1997
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.
1993
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells
2000
B7-CD28 Interaction Promotes Proliferation and Survival but Suppresses Differentiation of CD4−CD8− T Cells in the Thymus
2004
Requirements for Allergen-Induced Airway Hyperreactivity in T and B Cell-Deficient Mice
1998
Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice
1999
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
1996
Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment
1999 StandoutNobel
Rearranging Views on Neurogenesis
1999
ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements
1996
Allelic Exclusion in pTα-deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-β Chains, but Less Efficient Inhibition of Endogeneous Vβ→ (D)Jβ Rearrangements in the Presence of a Functional TCR-β Transgene
1997
A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development.
1997
Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation
1993 Science
Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins
1996 StandoutScienceNobel
Regulated Costimulation in the Thymus Is Critical for T Cell Development: Dysregulated CD28 Costimulation Can Bypass the Pre-TCR Checkpoint
2005 StandoutNobel
Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis
1998
Analysis and Expression of a Cloned Pre-T Cell Receptor Gene
1994 Science
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Receptor Selection in B and T Lymphocytes
2000
V(D)J recombination coding junction formation without DNA homology: processing of coding termini.
1993
The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice
1996
The Common Cytokine Receptor γ Chain Controls Survival of γ/δ T Cells
1997
RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.
1994 Nobel
Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.
1995
Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination
2001 StandoutNobel
Intrathymic differentiation of V gamma 3 T cells.
1993 StandoutNobel
Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules
1997
CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice
1998 Nobel
Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.
1996
Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.
1993
Selective response of gamma delta T-cell hybridomas to orthomyxovirus-infected cells
1996 StandoutNobel
Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
1996
Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes
1999 Science
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
2009
Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.
1993
Mice cloned from embryonic stem cells
1999
Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements
1998
The Role of Igβ in Precursor B Cell Transition and Allelic Exclusion
1995 Science
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Differential Roles of Cytokine Receptors in the Development of Epidermal γδ T Cells
2001 StandoutNobel
Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes✪
2001
Role of Different T Cell Receptors in the Development of Pre–T Cells
1997
Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire
1993 Science
Works of John Iacomini being referenced
RAG-1-deficient mice have no mature B and T lymphocytes
1992 StandoutNobel
The influence of natural antibody specificity on antigen immunogenicity
2005
The effect of an immunoglobulin μ transgene on B cell maturation
1992
T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes
1993 Nobel
Adult bone marrow contains precursors for CD5+ B cells
1996
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
1992 NatureNobel
Domains of the TCR beta-chain required for early thymocyte development.
1996 Nobel
Endogenous Ig production in mu transgenic mice. II. Anti-Ig reactivity and apparent double allotype expression.
1993