Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Restoration of β-Adrenergic Receptor Signaling and Contractile Function in Heart Failure by Disruption of the βARK1/Phosphoinositide 3-Kinase Complex
2005
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
The trp ion channel family
2001
The Effects of AZT and DDI on Pre- and Postimplantation Mammalian Embryos: An In Vivo and In Vitro Study
1992
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy
2001 StandoutNobel
Complexity in simplicity: monogenic disorders and complex cardiomyopathies
1999
Extracellular Signal-regulated Protein Kinase Activation Is Required for the Anti-hypertrophic Effect of Atrial Natriuretic Factor in Neonatal Rat Ventricular Myocytes
1999
A comparison of the genes coding for canonical TRP channels and their M, V and P relatives
2003
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Genetic manipulation of myocardial ?-adrenergic receptor activation and desensitization
2004
From worm to man: three subfamilies of TRP channels
2000
β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse
1999
Prospects for Cardiovascular Research
2001 StandoutNobel
TRP channels and lipids: from Drosophila to mammalian physiology
2006
Transient receptor potential channelopathies
2010
Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3)
2003
BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity
1997
Stress Pathways and Heart Failure
1999
Comparison of Three Members of the Cysteine-rich Protein Family Reveals Functional Conservation and Divergent Patterns of Gene Expression
1997
Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
1999
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient mice
2001 StandoutNobel
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Transgenic Mice with Cardiac Overexpression of α1B-Adrenergic Receptors
1997 StandoutNobel
Decoding calcium signals involved in cardiac growth and function
2000
Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells
1998
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
2000 StandoutNatureNobel
Gβγ-dependent Phosphoinositide 3-Kinase Activation in Hearts with in Vivo Pressure Overload Hypertrophy
2000
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Physiological consequences of β-adrenergic receptor disruption
1998
Structural Conservation of the Genes Encoding CaT1, CaT2, and Related Cation Channels
2001
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
TRP channels as cellular sensors
2003 StandoutNature
G protein‐coupled receptor signalling in in vivo cardiac overload
2001
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Interaction between the C. elegans cell-death regulators CED-9 and CED-4
1997 Nature
Defective β-Adrenergic Receptor Signaling Precedes the Development of Dilated Cardiomyopathy in Transgenic Mice with Calsequestrin Overexpression
1999
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3
2003
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity
2001
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Why does the myocardium fail? Insights from basic science
1998
Dimerization Properties of Human BAD
1997
Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice
1998 StandoutNobel
Chronic Phospholamban–Sarcoplasmic Reticulum Calcium ATPase Interaction Is the Critical Calcium Cycling Defect in Dilated Cardiomyopathy
1999
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Agonist-dependent Recruitment of Phosphoinositide 3-Kinase to the Membrane by β-Adrenergic Receptor Kinase 1
2001
Adult mice deficient in actinin–associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy
2001
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Myocardial G Protein‐Coupled Receptor Kinases: Implications for Heart Failure Therapy
1999
The role of cytoskeletal proteins in cardiomyopathies
1998
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Errors of homeostasis and deregulated apoptosis
1997
Seven-transmembrane receptors
2002 StandoutNobel
BID: a novel BH3 domain-only death agonist.
1996
LIM domains: multiple roles as adapters and functional modifiers in protein interactions
1998 Standout
Inhibition of receptor-localized PI3K preserves cardiac β-adrenergic receptor function and ameliorates pressure overload heart failure
2003
Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment
1994 Standout
Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.
1995
Rescue of Contractile Parameters and Myocyte Hypertrophy in Calsequestrin Overexpressing Myocardium by Phospholamban Ablation
2001
Mechanisms of Acute Desensitization of the β 2 AR–Adenylyl Cyclase Pathway in Human Airway Smooth Muscle
1998
Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex
2002
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
2000
Muscle LIM Protein Promotes Myogenesis by Enhancing the Activity of MyoD
1997
In Vivo Ventricular Gene Delivery of a β-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction
2001 StandoutNobel
Signaling in Myocardial Hypertrophy
1999
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
1993 StandoutNobel
Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.
2001
Early and Delayed Consequences of β 2 -Adrenergic Receptor Overexpression in Mouse Hearts
2000
Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family
1998
Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress
2002
The TRP Superfamily of Cation Channels
2005
Mice Expressing Mutant Myosin Heavy Chains Are a Model for Familial Hypertrophic Cardiomyopathy
1996
Functional Consequences of Altering Myocardial Adrenergic Receptor Signaling
2000 StandoutNobel
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Transgenic Gαq overexpression induces cardiac contractile failure in mice
1997
β-Adrenergic Receptor Signaling: An Acute Compensatory Adjustment—Inappropriate for the Chronic Stress of Heart Failure?
2000
Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus
1997
A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans
1999 StandoutNobel
Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α
1997
Effect of zidovudine on preimplantation murine embryos
1993
Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy
2000
Cellular and functional defects in a mouse model of heart failure
2000
Recent Advances in Cardiac β2-Adrenergic Signal Transduction
1999
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs
1997
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
1997 StandoutNobel
Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy
2001
Cardiac-Directed Adenylyl Cyclase Expression Improves Heart Function in Murine Cardiomyopathy
1999
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs
1998
Immunocyte Ca 2+ Influx System Mediated by LTRPC2
2001 Science
Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
1997 StandoutNobel
Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction
1999
Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death
1997 Science
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure
2001 StandoutNobel
Low- and high-level transgenic expression of β 2 -adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice
1999
Reciprocal In Vivo Regulation of Myocardial G Protein–Coupled Receptor Kinase Expression by β-Adrenergic Receptor Stimulation and Blockade
1998 StandoutNobel
Bad Is a BH3 Domain-Containing Protein That Forms an Inactivating Dimer with Bcl-XL
1997
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
Adenylylcyclase Increases Responsiveness to Catecholamine Stimulation in Transgenic Mice
1999
Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment
2006
Overexpression of the Cardiac β2-Adrenergic Receptor and Expression of a β-Adrenergic Receptor Kinase-1 (βARK1) Inhibitor Both Increase Myocardial Contractility but Have Differential Effects on Susceptibility to Ischemic Injury
1999 StandoutNobel
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene
2001
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Adenylyl Cyclase Increases Survival in Cardiomyopathy
2002
Phospholamban deficiency does not compromise exercise capacity
1999
Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A
2001
Cardiac-Specific Ablation of G-Protein Receptor Kinase 2 Redefines Its Roles in Heart Development and β-Adrenergic Signaling
2006
In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function
1999 StandoutNobel
Catecholamines, Cardiac β-Adrenergic Receptors, and Heart Failure
2000 StandoutNobel
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
Is calcium the 'cure' for dilated cardiomyopathy?
1999
The Myocardial β-Adrenergic System in Spontaneously Hypertensive Heart Failure (SHHF) Rats
1999
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
2001 StandoutScienceNobel
TRP Channels
2007 Standout
Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction
2000 StandoutNobel
Level of β-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload–Induced Heart Failure
2005 StandoutNobel
What Is the Role of β-Adrenergic Signaling in Heart Failure?
2003
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of John Hunter being referenced
Evidence for α-Helical Conformation of an Essential N-terminal Region in the Human Bcl2 Protein
1996
Chromosomal Localization and Genomic Characterization of the Mouse Melastatin Gene (Mlsn1)
1998
Role of abortive retroviral infection of neurons in spongiform CNS degeneration
1990 Nature
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.
1996
A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis
1996
Signaling Pathways for Cardiac Hypertrophy and Failure
1999
Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase
1997
MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure
1997
Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice
1995
The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy
1997
Signaling Pathways for Cardiac Growth and Hypertrophy
1995
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
Maternal transmission of retroviral disease: transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy.
1988
Characterization of the Nuclear Export Signal of Human T-Cell Lymphotropic Virus Type 1 Rex Reveals that Nuclear Export Is Mediated by Position-Variable Hydrophobic Interactions
1996
Maternal transmission of retroviral disease and strategies for preventing infection of the neonate
1989
Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.
1998
Transthoracic Echocardiography in Models of Cardiac Disease in the Mouse
1996
Functional Dissection of the Human Bcl2 Protein: Sequence Requirements for Inhibition of Apoptosis
1996
Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice
1997