Standout Papers
Citation Impact
Citing Papers
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance
2014 StandoutNobel
Serotonin Transporter Genetic Variation and the Response of the Human Amygdala
2002 StandoutScience
The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity
2011
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading
2012 Standout
Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions
2000
How chemokines organize the tumour microenvironment
2023
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
1994 StandoutNature
The dorsal premotor cortex orchestrates concurrent speech and fingertapping movements
2009
The functional neuroanatomy of coordinated orofacial movements: Sparse sampling fMRI of whistling
2005
Release Probability-Dependent Scaling of the Postsynaptic Responses at Single Hippocampal GABAergic Synapses
2006
Analyzing the factors underlying the structure and computation of the meaning of chipmunk, cherry, chisel, cheese, and cello (and many other such concrete nouns).
2003
Speech production: Wernicke, Broca and beyond
2002
Molecular Chlorine Generated by the Myeloperoxidase-Hydrogen Peroxide-Chloride System of Phagocytes Converts Low Density Lipoprotein Cholesterol into a Family of Chlorinated Sterols
1996
Estimation of nonuniform quantal parameters with multiple-probability fluctuation analysis: theory, application and limitations
2003
Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro
1999
Kinetic and Spectroscopic Characterization of a Hydroperoxy Compound in the Reaction of Native Myoglobin with Hydrogen Peroxide
2003
Biomarkers of myeloperoxidase-derived hypochlorous acid
2000
Myeloperoxidase produces nitrating oxidants in vivo
2002
Macrophage Myeloperoxidase Regulation by Granulocyte Macrophage Colony-Stimulating Factor in Human Atherosclerosis and Implications in Acute Coronary Syndromes
2001
Alzheimer's disease
2011 Standout
Estrogen receptor α is a major mediator of 17β-estradiol’s atheroprotective effects on lesion size in Apoe–/– mice
2001 StandoutNobel
X-ray crystal structure of canine myeloperoxidase at 3 Å resolution
1992
p-Hydroxyphenylacetaldehyde, the Major Product of l-Tyrosine Oxidation by the Myeloperoxidase-H2O2-Chloride System of Phagocytes, Covalently Modifies ε-Amino Groups of Protein Lysine Residues
1997
Tissue Destruction by Neutrophils
1989 Standout
Myeloperoxidase-derived Reactive Chlorinating Species from Human Monocytes Target Plasmalogens in Low Density Lipoprotein
2003
Biological markers of intellectual disability in tuberous sclerosis
2007
Semantic memory and the brain: structure and processes
2001
p-Hydroxyphenylacetaldehyde, an Aldehyde Generated by Myeloperoxidase, Modifies Phospholipid Amino Groups of Low Density Lipoprotein in Human Atherosclerotic Intima
2000
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
1997 Standout
Functional MRI assessment of orofacial articulators: Neural correlates of lip, jaw, larynx, and tongue movements
2011
CSF Biomarkers
2009
ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials
2016
Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
1994
Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7)
2001
Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
2013 StandoutNobel
Quantal Size Is Independent of the Release Probability at Hippocampal Excitatory Synapses
2005
Effects of generation mode in fMRI adaptations of semantic fluency: Paced production and overt speech
2007
Association Between Myeloperoxidase Levels and Risk of Coronary Artery Disease
2001
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Discriminating between Auditory and Motor Cortical Responses to Speech and Nonspeech Mouth Sounds
2011
Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
2013
Alzheimer's disease
2015
A neuromodulatory role for the human amygdala in processing emotional facial expressions
1998
An Implicit Learning Task Activates Medial Temporal Lobe in Patients With Parkinson's Disease.
2004
Glial and neuronal control of brain blood flow
2010 StandoutNature
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Cholesterol Chlorohydrin Synthesis by the Myeloperoxidase-Hydrogen Peroxide-Chloride System: Potential Markers for Lipoproteins Oxidatively Damaged by Phagocytes
1994
Separate neural subsystems within `Wernicke's area'
2001
Rethinking schizophrenia
2010 StandoutNature
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.
1997
Current and evolving treatment strategies for the Alzheimer disease continuum
2020
Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex
2003
Lysine Residues Direct the Chlorination of Tyrosines in YXXK Motifs of Apolipoprotein A-I When Hypochlorous Acid Oxidizes High Density Lipoprotein
2004
Tuberous sclerosis
2008 Standout
Heme-thiolate haloperoxidases: versatile biocatalysts with biotechnological and environmental significance
2006
Myeloperoxidase-generated oxidants and atherosclerosis
2000
Alzheimer's disease
2016 Standout
Widespread anatomical abnormalities of grey and white matter structure in tuberous sclerosis
2001
Increased atherosclerosis in myeloperoxidase-deficient mice
2001
The role of metallobiology and amyloid‐β peptides in Alzheimer’s disease
2011
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases
2000
Consensus clinical guidelines for the assessment of cognitive and behavioural problems in Tuberous Sclerosis
2005
Alzheimer's Disease
2010 Standout
Inflammation in atherosclerosis
2002 StandoutNature
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
2000
Nitrogen dioxide radical generated by the myeloperoxidase‐hydrogen peroxide‐nitrite system promotes lipid peroxidation of low density lipoprotein
1999
The somatotopy of speech: Phonation and articulation in the human motor cortex
2009
22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia
2010
The role of iron in brain ageing and neurodegenerative disorders
2014 Standout
Human brain activation during phonation and exhalation: Common volitional control for two upper airway functions
2007
The Oxidation of Lipoproteins by Monocytes-Macrophages
1999
Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite
1997
Chlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils
1995
Molecular tuning of electroreception in sharks and skates
2018 StandoutNatureNobel
Effects of monoclonal antibodies against amyloid-β on clinical and biomarker outcomes and adverse event risks: A systematic review and meta-analysis of phase III RCTs in Alzheimer’s disease
2021
The role of oxidized lipoproteins in atherogenesis
1996
A direct demonstration of functional specialization within motion-related visual and auditory cortex of the human brain
1996
Atherosclerosis
2000 StandoutNature
An fMRI investigation of syllable sequence production
2006
Hypochlorous Acid Generated by Myeloperoxidase Modifies Adjacent Tryptophan and Glycine Residues in the Catalytic Domain of Matrix Metalloproteinase-7 (Matrilysin)
2003
Human neutrophils employ chlorine gas as an oxidant during phagocytosis.
1996
Atherosclerosis
2001 Standout
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Common Neural Substrates for Inhibition of Spoken and Manual Responses
2008
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis
1998
The myeloperoxidase system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation
1999
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Activity‐induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow
2005
Human primary motor cortex shows hemispheric specialization for speech
2006
Specific Uptake of an Amyloid-β Protofibril-Binding Antibody-Tracer in AβPP Transgenic Mouse Brain
2013
Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils.
1983
Oxidative inactivation of leukotriene C 4 by stimulated human polymorphonuclear leukocytes
1982 StandoutNobel
Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones
1997
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Lecanemab in Early Alzheimer’s Disease
2022 Standout
Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils.
1984
Organic Photoredox Catalysis
2016 Standout
N‐(2‐Oxoacyl)amino Acids and Nitriles as Final Products of Dipeptide Chlorination Mediated by the Myeloperoxidase/H2O2/Cl− System
1978
Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall
1999
Biomedical applications of copper ionophores
2020
The importance of free radicals and catalytic metal ions in human diseases
1985
Oxygen-Dependent Microbial Killing by Phagocytes
1978 Standout
Predicting Human Brain Activity Associated with the Meanings of Nouns
2008 StandoutScience
Synthesis, Isolation, and Characterization of the Adduct Formed in the Reaction of p-Hydroxyphenyl- acetaldehyde with the Amino Headgroup of Phosphatidylethanolamine and Phosphatidylserine
1998
An efficient and general route to reduced polypropionates via Zr-catalyzed asymmetric C—C bond formation
2004 StandoutNobel
Brain regions involved in motor control of speech
2004
Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages
1993
Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.
1993
[1] Role of free radicals and catalytic metal ions in human disease: An overview
1990 Standout
Specific covalent labeling of cytochrome P-450CAM with 1-(4-azidophenyl)imidazole, an inhibitor-derived photoaffinity probe for P-450 heme proteins.
1979
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation
1994
Preliminary crystallographic data on cytochrome P-450CAM.
1982
The Tuberous Sclerosis Complex and its Highly Variable Manifestations
2003
Active site studies of cytochrome P=450CAM. I. Specific cysteine labeling with the affinity reagent isobornyl bromoacetate as a model for substrate binding.
1982
Mass Spectrometric Quantification of Markers for Protein Oxidation by Tyrosyl Radical, Copper, and Hydroxyl Radical in Low Density Lipoprotein Isolated from Human Atherosclerotic Plaques
1997
Development of a Bulk Enabling Route to Maraviroc (UK-427,857), a CCR-5 Receptor Antagonist
2008
Oxidative Stress, Caloric Restriction, and Aging
1996 StandoutScience
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Metal-Mediated Reductive Hydrodehalogenation of Organic Halides
2002
Molecular mechanism for depolarization-induced modulation of Kv channel closure
2012
Heme binding and substrate-protected cysteine residues in P-450cam
1983
Electron paramagnetic resonance detectable states of cytochrome P-450cam
1980
Formation of singlet oxygen by the myeloperoxidase-mediated antimicrobial system.
1977
Tandem Catalysis: The Sequential Mediation of Olefin Metathesis, Hydrogenation, and Hydrogen Transfer with Single-Component Ru Complexes
2001 StandoutNobel
Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.
1981
Insights into the active site of the cytochrome P-450 haemoprotein family-a unifying concept based on structural considerations
1982
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Science and technology for water purification in the coming decades
2008 StandoutNature
Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of oxidant to hypochlorite
1985
Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.
1994
Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.
1981
[40] Preparation and characterization of chloramines
1986
Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid
1988
Behavioral and Cognitive Aspects of Tuberous Sclerosis Complex
2004
A potential role for hypochlorous acid in granulocyte-mediated tumor cell cytotoxicity
1980
Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines.
1984
Chlorination of Taurine by Human Neutrophils
1982
Myeloperoxidase produces nitrating oxidants in vivo
2002
Assessment of chlorination by human neutrophils
1983 Nature
Emerging Targets in Photopharmacology
2016 StandoutNobel
Biochemical requirements for singlet oxygen production by purified human myeloperoxidase.
1984
Human Neutrophils Employ Myeloperoxidase To Convert α-Amino Acids to a Battery of Reactive Aldehydes: A Pathway for Aldehyde Generation at Sites of Inflammation
1998
Deracemizing α‐Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis‐Silyl Ketene Acetals with Water or Methanol
2019 StandoutNobel
A Cortical Area Selective for Visual Processing of the Human Body
2001 StandoutScience
Dynamic mapping of human cortical development during childhood through early adulthood
2004 Standout
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
2008 StandoutScience
Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation
2009 Standout
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
Generation of Intramolecular and Intermolecular Sulfenamides, Sulfinamides, and Sulfonamides by Hypochlorous Acid: A Potential Pathway for Oxidative Cross-Linking of Low-Density Lipoprotein by Myeloperoxidase
2001
Biochemical and Immunologic Analysis of Hereditary Myeloperoxidase Deficiency
1983
Oxygen radical-induced erythrocyte hemolysis by neutrophils. Critical role of iron and lactoferrin.
1985
Amino acid sequence of the Pseudomonas putida cytochrome P-450. II. Cyanogen bromide peptides, acid cleavage peptides, and the complete sequence.
1982
Myeloperoxidase-catalyzed incorporation of amines into proteins: role of hypochlorous acid and dichloramines
1982
Monocyte and granulocyte-mediated tumor cell destruction. A role for the hydrogen peroxide-myeloperoxidase-chloride system.
1982
A Unique Class of Near-Infrared Functional Fluorescent Dyes with Carboxylic-Acid-Modulated Fluorescence ON/OFF Switching: Rational Design, Synthesis, Optical Properties, Theoretical Calculations, and Applications for Fluorescence Imaging in Living Animals
2011
Co-oxidation of luminol by hypochlorite and hydrogen peroxide implications for neutrophil chemiluminescence
1985
Structure and Chemistry of Cytochrome P450
2005 Standout
Role of monochloramine in the oxidation of erythrocyte hemoglobin by stimulated neutrophils.
1984
Catalytic, Efficient, and syn-Selective Construction of Deoxypolypropionates and Other Chiral Compounds via Zr-Catalyzed Asymmetric Carboalumination of Allyl Alcohol
2006 StandoutNobel
Works of John Harrison being referenced
A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia
2010
Saccadic eye movement and working memory deficits following damage to human prefrontal cortex
1998
A Neuropsychological Test Battery for Use in Alzheimer Disease Clinical Trials
2007
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
2008
Serial reaction time learning and Parkinson's disease: Evidence for a procedural learning deficit
1995
The physiology of coloured hearing A PET activation study of colour-word synaesthesia
1995
The subunit structure of crystalline canine myeloperoxidase
1977
PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses
2010
Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study
2018
Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial
2012
FDA position statement “Early Alzheimer's disease: Developing drugs for treatment, Guidance for Industry”
2018
Studies on the chlorinating activity of myeloperoxidase.
1976 Standout
Synthesis and characterization of lithium aminoborohydrides: A new class of powerful reducing agents
1992
Aminoborohydrides. 3. A facile reduction of tertiary amides to the corresponding amines and alcohols in high purity using lithium aminoborohydrides. Sterically controlled selective CN or CO bond cleavage
1993
Cognitive deficits in normally intelligent patients with tuberous sclerosis
1999
Myeloperoxidase: Confirmation and nature of heme-binding inequivalence
1978
Myeloperoxidase and singlet oxygen: a reappraisal
1978
Aminoborohydrides. 4. The Synthesis and Characterization of Lithium Aminoborohydrides: A New Class of Powerful, Selective, Air-Stable Reducing Agents
1994
Compound I of myeloperoxidase
1980
Superfluous Role of Mammalian Septins 3 and 5 in Neuronal Development and Synaptic Transmission
2008
Tolerability and Safety of Souvenaid in Patients with Mild Alzheimer's Disease: Results of Multi-Center, 24-Week, Open-Label Extension Study
2015
Receptor Occupancy Limits Synaptic Depression at Climbing Fiber Synapses
2003
Cerebral areas associated with motor control of speech in humans
1997
Cytochrome P450cam: SS- dimer and -SH derivative reactivities
1978
Annotation: Tuberous Sclerosis
1997