John H. Dodd

The 2.6 Angstrom Crystal Structure of a Human A _2A Adenosine Receptor Bound to an Antagonist

Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors

Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Gold Catalysis

Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor

Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7

Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor11Abbreviations: CCPA, 2-chloro-N6-cyclopentyladenosine; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; CPA, N6-cyclopentyladenosine, R-PIA, N6-[-(R)-1-methyl-2-phenylethyl]adenosine; NECA, 5′-(N-ethyl)-carboxamidoadenosine; N-0840, N6-cyclopentyl-9-methyladenine; theophylline, 1,3-dimethylxanthine; PD81,723, (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone; BCA, bicinchoninic acid; BCS, bovine calf serum; cAMP, adenosine 3′,5′-cyclic monophosphate; DMEM, Dulbecco’s modified Eagle’s medium; CHO, Chinese hamster ovary; and wt, wild-type.

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

Allosteric Modulation of the Adenosine Family of Receptors

Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use

High-resolution crystal structure of human protease-activated receptor 1

Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor

Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators

Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor

Palladium(II)‐Catalyzed CH Activation/CC Cross‐Coupling Reactions: Versatility and Practicality

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

One‐Pot Three‐Component Synthesis of 3‐nitro‐2‐arylimidazo[1,2‐a]pyridine Derivatives Using Air as an Oxidant

Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers

The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins

The impact of microwave synthesis on drug discovery

Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer

Kinomics—structural biology and chemogenomics of kinase inhibitors and targets

Oxidative Geminal Functionalization of Organoboron Compounds

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

Hypervalent‐Iodine‐Mediated Cascade Annulation of Diarylalkynes Forming Spiro Heterocycles under Metal‐Free Conditions

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

Iron catalysed direct alkylation of amines with alcohols

Memory of Extracellular Adenosine A2A Purinergic Receptor-mediated Signaling in Murine T Cells

2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

Gold‐Catalyzed Redox Synthesis of Imidazo[1,2‐a]pyridines using Pyridine N‐Oxide and Alkynes

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential

Allosteric modulation of A2A adenosine receptors by amiloride analogues and sodium ions

Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination

Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

Benzimidazolone p38 inhibitors

Electrochemical Intramolecular CH Amination: Synthesis of Benzoxazoles and Benzothiazoles

Controlled Microwave Heating in Modern Organic Synthesis

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

Binding Site Detection and Druggability Index from First Principles

Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans

Electrochemical intramolecular dehydrogenative C–S bond formation for the synthesis of benzothiazoles

Iron Catalysis in Organic Synthesis

Copper‐Catalyzed Decarboxylative Three‐Component Reactions for the Synthesis of Imidazo[1,2‐a]pyridines

3d Transition Metals for C–H Activation

Copper-Catalyzed Three-Component System for Arylsulfenylation of Imidazopyridines with Elemental Sulfur

Copper‐Catalyzed Intermolecular Oxidative Cyclization of Halo‐ alkynes: Synthesis of 2‐Halo‐substituted Imidazo[1,2‐a]pyridines, Imidazo[1,2‐a]pyrazines and Imidazo[1,2‐a]pyrimidines

Ring Expansion via Olefin Metathesis

Copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder and coumarinyl triflates

The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs

Iodobenzene Diacetate–Promoted N–N and N–O Bond Formation for Pyrazolo- and Isoxazolopyrimidine Syntheses

Cobalt-catalyzed cross-dehydrogenative coupling of imidazo[1,2-a]pyridines with isochroman using molecular oxygen as the oxidant

Palladium-Catalyzed Synthesis of 2-Substituted Benzothiazoles via a C−H Functionalization/Intramolecular C−S Bond Formation Process

Biarylphosphanliganden in der palladiumkatalysierten Aminierung

Synthesis and Functionalization of Indoles Through Palladium-catalyzed Reactions

Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy

Hybrid Ortho/Allosteric Ligands for the Adenosine A₁Receptor

Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors

Total Syntheses of (S)-(−)-Zearalenone and Lasiodiplodin Reveal Superior Metathesis Activity of Ruthenium Carbene Complexes with Imidazol-2-ylidene Ligands

Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

Allosteric Modulators of the Adenosine A₁Receptor: Synthesis and Pharmacological Evaluation of 4-Substituted 2-Amino-3-benzoylthiophenes

Iron(III)‐Catalyzed Denitration Reaction: One‐Pot Three‐Component Synthesis of Imidazo[1,2‐a]pyridine Derivatives

Palladium-Catalyzed Amination of N-Free 2-Chloro-7-azaindole

Advances in the Chemistry of Tetrahydroquinolines

Pyrazole Urea-Based Inhibitors of p38 MAP Kinase:  From Lead Compound to Clinical Candidate

Hydrogen Autotransfer in the N-Alkylation of Amines and Related Compounds using Alcohols and Amines as Electrophiles

Adenosine A1 Receptor-Dependent and -Independent Effects of the Allosteric Enhancer PD 81,723

Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions

Palladium-catalyzed functionalization of 5- and 7-azaindoles

Multicomponent synthesis of imidazo[1,2-a]pyridines using catalytic zinc chloride

Tandem Catalysis:  The Sequential Mediation of Olefin Metathesis, Hydrogenation, and Hydrogen Transfer with Single-Component Ru Complexes

Synthesis of imidazo[1,2-a]pyridines: a decade update

A convenient synthesis of pyrrolopyridines and 2-substituted indoles by gold-catalyzed cycloisomerization

Microwave-Assisted Synthesis in Water as Solvent

Aerobic Copper-Catalyzed Organic Reactions

Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance

Enantioselective Copper-Catalyzed Alkynylation of Benzopyranyl Oxocarbenium Ions

Copper(I) Iodide‐Catalysed Aerobic Oxidative Synthesis of Imidazo[1,2‐a]pyridines from 2‐Aminopyridines and Methyl Ketones

Alternative Synthetic Methods through New Developments in Catalysis by Gold

Fast microwave promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo(CO) 6 as carbon monoxide sources

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

Advances in Synthetic Applications of Hypervalent Iodine Compounds

Elucidation of structure-activity relationships of 2-amino-3-benzoylthiophenes: Study of their allosteric enhancing vs. antagonistic activity on adenosine A1 receptors

Recent developments in palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C–Z (Z = B, Si, Sn, S, N, C, H) bonds in bi(hetero)aryl synthesis

Tandem approach for the synthesis of imidazo[1,2-a]pyridines from alcohols

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis

Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions

TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling

InBr3-catalyzed three-component, one-pot synthesis of imidazo[1,2-a]pyridines

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

Synthesis of Imidazo[1,2-a]pyridines: “Water-Mediated” Hydroamination and Silver-Catalyzed Aminooxygenation

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

PD 81,723, an Allosteric Enhancer of the A₁Adenosine Receptor, Lowers the Threshold for Ischemic Preconditioning in Dogs

Gold-Catalyzed Carbon−Heteroatom Bond-Forming Reactions

Cu(OTf)2-catalyzed synthesis of imidazo[1,2-a]pyridines from α-diazoketones and 2-aminopyridines

Conversion of Pyridine to Imidazo[1,2-a]pyridines by Copper-Catalyzed Aerobic Dehydrogenative Cyclization with Oxime Esters

Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications

Chemistry and Biology Of Multicomponent Reactions

Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions

Gold-Catalyzed Organic Reactions

Rh-Catalyzed Intermolecular Reactions of Cyclic α-Diazocarbonyl Compounds with Selectivity over Tertiary C–H Bond Migration

A Medicinal Chemist’s Guide to Molecular Interactions

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

Biosynthesis and Stereochemistry of Phlegmacin‐Type Fungal Pigments

Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

Gold‐Catalyzed C‐3‐Alkylation of 7‐Azaindoles Through Michael‐Type Addition to α,β‐Enones

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

Design and Synthesis of a Tetracyclic Pyrimidine-Fused Benzodiazepine Library

Cu(I)-Catalyzed Synthesis of Imidazo[1,2-a]pyridines from Aminopyridines and Nitroolefins Using Air as the Oxidant

Energetics of Displacing Water Molecules from Protein Binding Sites: Consequences for Ligand Optimization

Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes.

The development of novel and selective p56lck tyrosine kinase inhibitors

Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase

Imidazopyrimidines, potent inhibitors of p38 MAP kinase

Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

Benzothiazole based inhibitors of p38α MAP kinase

Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure–activity relationships

Potent inhibitors of the MAP kinase p38

Phosphodiesterase 7A-Deficient Mice Have Functional T Cells

Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38

Synthesis of spiro[2H‐indole‐2,1′‐1H‐isoindole]‐3,3′‐diones, spiro[1H‐isobenzofuran‐1,2′‐2H‐indole]‐3,3′‐diones and spiro[benzofuran‐2,1′‐isobenzofuran]‐3,3′‐diones via transannular reactions of eight membered ring intermediates

Stereoselectivity in the rhodium(II) acetate catalysed cyclopropanations of 2-diazo-1-indanone with styrenes

5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354):  A Potent and Selective p38 Kinase Inhibitor

Synthesis of the carbon framework of olivin

ortho-Toluate Carbanion Chemistry: Sulfenylation and Selenation

Development of a strategy for convergent total synthesis of the aureolic acid antitumor antibiotics