Standout Papers
Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
Affinity and Avidity in Antibody-Based Tumor Targeting
2009
Vascular and interstitial barriers to delivery of therapeutic agents in tumors
1990
Predicting plasma protein binding of drugs: a new approach
2002
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor
1995 StandoutNatureNobel
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
2013 Standout
Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers
2006
Vascular targeting—a new approach to the therapy of solid tumors
1994
Penetration of Tumor Tissue by Antibodies and Other Immunoproteins
1991
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Ca2+ Pools and Cell Growth: Arachidonic Acid Induces Recovery of Cells Growth-arrested by Ca2+ Pool Depletion
1996
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Structure of Serum Albumin
1994 Standout
The macroscopic and microscopic pharmacology of monoclonal antibodies
1992
G Protein-coupled Receptors
1998 StandoutNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Atomic structure and chemistry of human serum albumin
1992 StandoutNature
A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways
2007
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
1988 StandoutNature
Movement of fatty acids, fatty acid analogs, and bile acids across phospholipid bilayers
1993
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
1997 StandoutNatureNobel
Drug Resistance and the Solid Tumor Microenvironment
2007 Standout
Palmitoylation of the human β2-adrenergic receptor
1989 StandoutNobel
Alpha-Adrenergic Receptor Subtypes
1980 StandoutNobel
Site-site interactions among insulin receptors. Characterization of the negative cooperativity.
1976
Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.
1992
Ca2+ binding and conformational change in two series of point mutations to the individual Ca(2+)-binding sites of calmodulin.
1992
Species-dependent differences in the nature of endothelium-derived vascular relaxing factor
1984
Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies
1982 Science
Determination of the Tryptophan Content of Proteins by Ion Exchange Chromatography of Alkaline Hydrolysates
1972 StandoutNobel
Agonist versus antagonist binding to alpha-adrenergic receptors.
1980 StandoutNobel
Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.
1980 StandoutNobel
Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.
1982 StandoutNobel
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles
2004 StandoutNobel
Serum Albumin
1970
Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
1992 StandoutNobel
Insulin interactions with its receptors: Experimental evidence for negative cooperativity
1973
Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
2001 StandoutScience
Mathematical theory of complex ligand-binding systems at equilibrium: Some methods for parameter fitting
1972
Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P
2009
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors
1983 StandoutNobel
Differential regulation of the α2-adrenergic receptor by Na+ and guanine nucleotides
1980 StandoutNatureNobel
Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
1998 StandoutScience
Effect of Inhibition of Vascular Endothelial Growth Factor Signaling on Distribution of Extravasated Antibodies in Tumors
2006
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
1993 StandoutNobel
Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
1991
Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts
1975 StandoutNobel
The location of drug binding sites in human serum albumin
1981
Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor
1989 StandoutNobel
Mechanisms of Membrane-Receptor Regulation
1984 StandoutNobel
Three-dimensional structure of calmodulin
1985 StandoutNature
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
1980 StandoutNobel
Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes. Theoretical approach to study of multiple ligand binding to a macromolecule
1981
Dynamic Kinetic Resolution of Racemic β-Haloalcohols: Direct Access to Enantioenriched Epoxides
2008 StandoutNobel
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
2005 StandoutNature
Binding of α-factor pheromone to yeast a cells: Chemical and genetic evidence for an α-factor receptor
1983 StandoutNobel
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release.
1978 StandoutNobel
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ADIPOSE CELL
1970
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
1994 StandoutNobel
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Isoproterenol stimulates shift of G proteins from plasma membrane to pinocytotic vesicles in rat adipocytes: a possible means of signal dissemination.
1990 StandoutNobel
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
1984 StandoutNobel
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
1986 StandoutNature
Calmodulin
1982
Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes.
1976 StandoutNobel
Mathematics of Hormone-Receptor Interaction
1973
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.
1991 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
2014 StandoutNobel
Carbachol-activated muscarinic (M1 and M3) receptors transfected into Chinese hamster ovary cells inhibit trafficking of endosomes.
1991 StandoutNobel
Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.
1983 StandoutNobel
Works of John Fletcher being referenced
Alternative Models for the Analysis of Drug-Protein Binding
1977
Mathematical modeling of the microcirculation
1978
Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants
1971
INFLUENCE OF FREE FATTY ACID CONCENTRATION ON DRUG BINDING TO PLASMA ALBUMIN*
1973
Analysis of macromolecule-ligand binding by determination of stepwise equilibrium constants
1970
Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.
1989
Binding of long-chain fatty acids to bovine serum albumin
1969
A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.
1990