Standout Papers
Citation Impact
Citing Papers
Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity
2006
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis
2008
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice
2010
Effects of Parathyroid Hormone Treatment on Circulating Sclerostin Levels in Postmenopausal Women
2010
Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling
2009
High-Density Association Study of 383 Candidate Genes for Volumetric BMD at the Femoral Neck and Lumbar Spine Among Older Men
2009
Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
2010
Investigation of multipotent postnatal stem cells from human periodontal ligament
2004 Standout
Characterization of Wise Protein and Its Molecular Mechanism to Interact with both Wnt and BMP Signals
2009
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway
2009 StandoutNobel
Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors
2012
Characterization of the Structural Features and Interactions of Sclerostin
2009
EGFR Antagonists in Cancer Treatment
2008 Standout
The −9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPα and FOXA1 binding is associated with osteoporosis
2009
Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis
2005
B1b Lymphocytes Confer T Cell-Independent Long-Lasting Immunity
2004 StandoutNobel
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
Control of osteoblast function and regulation of bone mass
2003 Nature
Cbfa1/RUNX2 Directs Specific Expression of the Sclerosteosis Gene (SOST)
2004
Role of Transforming Growth Factor β in Human Disease
2000 Standout
Hypoxia‐induced increase in the production of extracellular matrix proteins in systemic sclerosis
2007
Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats
2006
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
2003 Standout
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
2002
Epidermal growth factor-related peptides and their receptors in human malignancies
1995 Standout
Emerging therapeutic opportunities for skeletal restoration
2011
Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton
2007
Genetic evidence that SOST inhibits WNT signaling in the limb
2010
Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells
1995
A 52‐kb deletion in the SOST‐MEOX1 intergenic region on 17q12‐q21 is associated with van Buchem disease in the Dutch population
2002 StandoutNobel
Cancer Metastasis: Building a Framework
2006 Standout
R‐spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
2008
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Lysyl oxidases: A novel multifunctional amine oxidase family
2001
Secreted and Transmembrane Wnt Inhibitors and Activators
2012
Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia
2011
Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density
2003
Survey of the year 2004 commercial optical biosensor literature
2005
Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo
2009
A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
2006 Standout
Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer
2004 Standout
AID is required for germinal center–derived lymphomagenesis
2007 StandoutNobel
Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway
2011
The multifaceted role of periostin in tumorigenesis
2009
Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
2008
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
2005
Scleroderma
2009 Standout
The natural history of sclerosteosis
2003
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
2005
Osteoporosis: now and the future
2011 Standout
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor
2005
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
2015 Standout
Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system
1998
Erlotinib in Previously Treated Non–Small-Cell Lung Cancer
2005 Standout
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Increased Bone Formation and Bone Mass Induced by Sclerostin Antibody Is Not Affected by Pretreatment or Cotreatment with Alendronate in Osteopenic, Ovariectomized Rats
2011
New sequence variants associated with bone mineral density
2008
TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome
2004
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Extracellular BMP-antagonist regulation in development and disease: tied up in knots
2010
NMR structure of the Wnt modulator protein Sclerostin
2009
Bone Mineral Density in Sclerosteosis; Affected Individuals and Gene Carriers
2005
Drug development in the era of precision medicine
2017
Sclerostin Is a Novel Secreted Osteoclast-derived Bone Morphogenetic Protein Antagonist with Unique Ligand Specificity
2003
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
Building strong bones: molecular regulation of the osteoblast lineage
2011
Polymorphisms in the Sclerosteosis/van Buchem Disease Gene (SOST) Region Are Associated with Bone-Mineral Density in Elderly Whites
2004 StandoutNobel
Sclerostin: how human mutations have helped reveal a new target for the treatment of osteoporosis
2013 StandoutNobel
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
2006
A Wnt canon orchestrating osteoblastogenesis
2006
The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations
2008
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
2011
Survey of the year 2003 commercial optical biosensor literature
2004
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms
2002
Chapter 13 Long‐Range Gene Control and Genetic Disease
2008
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
2007
Idiopathic pulmonary fibrosis
2011 Standout
Genetics of osteoporosis: accelerating pace in gene identification and validation
2009
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
2003
The TNF and TNF Receptor Superfamilies
2001 Standout
Molecular Bases of the Regulation of Bone Remodeling by the Canonical Wnt Signaling Pathway
2006
SOST is a target gene for PTH in bone
2005
MLL-mediated transcriptional gene regulation investigated by gene expression profiling
2003
Atherosclerosis
2001 Standout
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways
2010
Spatial partitioning of the regulatory landscape of the X-inactivation centre
2012 StandoutNature
Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2
2010
Romosozumab Treatment in Postmenopausal Women with Osteoporosis
2016
Mechanisms of Anabolic Therapies for Osteoporosis
2007
Update on Wnt signaling in bone cell biology and bone disease
2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
2014
Assembly and Regulation of the CD40 Receptor Complex in Human B Cells
1997
The role of Dickkopf-1 in bone development, homeostasis, and disease
2008
Patients with sclerosteosis and disease carriers: Human models of the effect of sclerostin on bone turnover
2011
Sclerostin antibody treatment enhances metaphyseal bone healing in rats
2010
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
2008 StandoutNobel
The two faces of serotonin in bone biology
2010
Structure and Spectroscopy of Copper−Dioxygen Complexes
2004 Standout
Sclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases
2012
RGD-CAP (βig-h3) Exerts a Negative Regulatory Function on Mineralization in the Human Periodontal Ligament
2002
Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism
2011
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
2001 StandoutNobel
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
2008
Van Buchem disease: Clinical, biochemical, and densitometric features of patients and disease carriers
2012
Anabolic and Catabolic Regimens of Human Parathyroid Hormone 1–34 Elicit Bone- and Envelope-Specific Attenuation of Skeletal Effects in Sost-Deficient Mice
2011
Sclerostin: A gem from the genome leads to bone-building antibodies
2010
TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation
1999 StandoutNobel
Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
2004
Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia.
2001
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones
2010
Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
2000 StandoutNobel
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39
1996
Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors
2007
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
2005 Standout
Wise, a context-dependent activator and inhibitor of Wnt signalling
2003
Gone with the Wnts: β-Catenin, T-Cell Factor, Forkhead Box O, and Oxidative Stress in Age-Dependent Diseases of Bone, Lipid, and Glucose Metabolism
2007
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators
2002
Update in New Anabolic Therapies for Osteoporosis
2010
Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice
2009
Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis
2006
From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis
2010 Standout
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Geometric cues for directing the differentiation of mesenchymal stem cells
2010 Standout
Origins and Functions of B-1 Cells with Notes on the Role of CD5
2002
Identification of Amino Acid Residues Important for Ligand Binding to Fas
1997
Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass
2006
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
2006 StandoutScience
TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome
2004
Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation
2006
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Oropharyngeal Skeletal Disease Accompanying High Bone Mass and Novel LRP5 Mutation
2005
X-linked immunodeficiency with hyper-IgM (XHIM)
2000
Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells
2001
Orally Bioavailable GSK-3α/β Dual Inhibitor Increases Markers of Cellular Differentiation In Vitro and Bone Mass In Vivo
2006
Transforming growth factor β and cancer
1995
Works of John E. Skonier being referenced
Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation
2004
Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein
2001 StandoutNobel
βIG-H3, a Novel Secretory Protein Inducible by Transforming Growth Factor-β, Is Present in Normal Skin and Promotes the Adhesion and Spreading of Dermal Fibroblasts In Vitro
1995
βig-h3: A Transforming Growth Factor-β-Responsive Gene Encoding a Secreted Protein That Inhibits Cell Attachment In Vitro and Suppresses the Growth of CHO Cells in Nude Mice
1994
cDNA Cloning and Sequence Analysis of βig-h3, a Novel Gene Induced in a Human Adenocarcinoma Cell Line after Treatment with Transforming Growth Factor-β
1992
Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins
2004
Regulation of Amphiregulin mRNA by TGF-β in the Human Lung Adenocarcinoma Cell Line A549
1992
Noggin and Sclerostin Bone Morphogenetic Protein Antagonists Form a Mutually Inhibitory Complex
2004
Identification of Residues in CD6 Which Are Critical for Ligand Binding
1997
Recognition of Diverse Proteins by Members of the Immunoglobulin Superfamily: Delineation of the Receptor Binding Site in the Human CD6 Ligand ALCAM
1996
Identification of Residues on CD40 and Its Ligand Which Are Critical for the Receptor-Ligand Interaction
1995