Citation Impact
Citing Papers
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
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Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
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In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
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Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
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Ferroptosis regulation by the NGLY1/NFE2L1 pathway
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Sculpting conducting nanopore size and shape through de novo protein design
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New inhibitors of the thioredoxin–thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead
2001
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
1998 Standout
Recent advances in the catalytic asymmetric synthesis of β-amino acids
2010 StandoutNobel
Purification and Properties of a Novel Chloroplast Stromal Peptidase
1998
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
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Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus
1999
Role of redox potential and reactive oxygen species in stress signaling
1999
News and views on thioredoxin reductases
1999
Glutathione redox potential in response to differentiation and enzyme inducers
1999
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Thioredoxin Expression and Localization in Human Cell Lines: Detection of Full-Length and Truncated Species
1997
Purification of Mitochondrial Thioredoxin Reductase and Its Involvement in the Redox Regulation of Membrane Permeability
1998
Preparation and assay of mammalian thioredoxin and thioredoxin reductase
1999
Redox Signaling and the Control of Cell Growth and Death
1996
Gene expression and the thiol redox state
1999
A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines
2003
Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression
2004
G6PD Deficient Cells and the Bioreduction of Disulfides: Effects of DHEA, GSH Depletion and Phenylarsine Oxide
2000
Cloning and Expression of a Novel Mammalian Thioredoxin
1997
The Thioredoxin System of the Malaria Parasite Plasmodium falciparum
2000
Redox Signaling and the Emerging Therapeutic Potential of Thiol Antioxidants
1998
Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells
1997
[21] Thioredoxin and thioredoxin reductase
1995
Human Placenta Thioredoxin Reductase
1998
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
The Large Subunit of Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase is Fragmented into 37-kDa and 16-kDa Polypeptides by Active Oxygen in the Lysates of Chloroplasts from Primary Leaves of Wheat
1997
Natural product based inhibitors of the thioredoxin–thioredoxin reductase system
2004
A Purified Zinc Protease of Pea Chloroplasts, EP1, Degrades the Large Subunit of Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase
1993
Acute Cadmium Exposure Inactivates Thioltransferase (Glutaredoxin), Inhibits Intracellular Reduction of Protein-glutathionyl-mixed Disulfides, and Initiates Apoptosis
2000
Improved Prediction of Signal Peptides: SignalP 3.0
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Free radicals and antioxidants in normal physiological functions and human disease
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Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA , selB and selC genes 1 1Edited by M. Gottesman
1999
Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
2004 StandoutNobel
Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2
1997
Physiological functions of thioredoxin and thioredoxin reductase
2000 Standout
Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue
1998
Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
2001
Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner
2008 StandoutNobel
Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue
1998
Redox Regulation of Cellular Signalling
1999
Methylseleninate Is a Substrate Rather Than an Inhibitor of Mammalian Thioredoxin Reductase
2002
Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer
1996
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.
2001 Standout
Inhibition of the c-Jun N-terminal Kinase/AP-1 and NF-κB Pathways by PICOT, a Novel Protein Kinase C-interacting Protein with a Thioredoxin Homology Domain
2000
Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants
2003
Separation of cytochrome c-dependent caspase activation from thiol-disulfide redox change in cells lacking mitochondrial DNA
2000
Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
2008
Thioredoxin, a putative oncogene product,is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival
2000
1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase
1995
Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants
2004
Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide
1999
Thioredoxin reductase as a pathophysiological factor and drug target
2000
Glutaredoxin Protects Cerebellar Granule Neurons from Dopamine-induced Apoptosis by Activating NF-κB via Ref-1
2001
Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.
1996
Functional Characterization of Recombinant Chloroplast Signal Recognition Particle
2001
Elevation of Manganese Superoxide Dismutase Gene Expression by Thioredoxin
1997
Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region
2000
Signal Peptidases
2002
Leaf Senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene
2002 StandoutNobel
The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
2002
Synthesis of Heterocycles via Electrophilic Cyclization of Alkynes Containing Heteroatom
2011 Standout
Mobilization of Rubisco and Stroma-Localized Fluorescent Proteins of Chloroplasts to the Vacuole by anATGGene-Dependent Autophagic Process
2008 StandoutNobel
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
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Global gene expression of cells attached to a tissue engineering scaffold
2004 StandoutNobel
Copper Active Sites in Biology
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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
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Luminescent Chemodosimeters for Bioimaging
2012 Standout
The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli
1997
Ultrafast solvation dynamics at binding and active sites of photolyases
2010 StandoutNobel
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.
1996
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
2003
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
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Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
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Induction of thioredoxin and thioredoxin reductase gene expression in lungs of newborn primates by oxygen
1999
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
1997
Vitamin D 3 –Upregulated Protein-1 (VDUP-1) Regulates Redox-Dependent Vascular Smooth Muscle Cell Proliferation Through Interaction With Thioredoxin
2002
Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo
2013 Standout
Chloroplast Outer Membrane β-Barrel Proteins Use Components of the General Import Apparatus
2019
Nrf1 Is Critical for Redox Balance and Survival of Liver Cells during Development
2003
Proteolysis in plants: mechanisms and functions
1996
The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase.
2000
Organoselenium Chemistry: Role of Intramolecular Interactions
2010 Standout
Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.
2000
Enantioselective Cyanation/Brook Rearrangement/C-Acylation Reactions of Acylsilanes Catalyzed by Chiral Metal Alkoxides
2004
Mitochondrial Protein Targets of Thiol-Reactive Electrophiles
2008
Dissection of complex protein dynamics in human thioredoxin
2007
Thioredoxin overexpression prevents NO-induced reduction of NO synthase activity in lung endothelial cells
1998
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Thioredoxin Reductase Mediates Cell Death Effects of the Combination of Beta Interferon and Retinoic Acid
1998
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.
2000
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Superoxide Ion: Generation and Chemical Implications
2016 Standout
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Advances in Copper Complexes as Anticancer Agents
2013 Standout
A Near-IR Reversible Fluorescent Probe Modulated by Selenium for Monitoring Peroxynitrite and Imaging in Living Cells
2011 Standout
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
2001 Standout
Selenium-based pharmacological agents: an update
2002
Tolerogenic Dendritic Cells
2003 StandoutNobel
REDOX REGULATION OF CELLULAR ACTIVATION
1997
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
1998 Standout
Structural Insights Into the Signal Recognition Particle
2004 StandoutNobel
A cell nanoinjector based on carbon nanotubes
2007 StandoutNobel
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
2002
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Characterization of Mammalian Selenoproteomes
2003 StandoutScience
Selenium-containing enzymes in mammals: Chemical perspectives
2005
A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.
1996
Processing of ATG8s, Ubiquitin-Like Proteins, and Their Deconjugation by ATG4s Are Essential for Plant Autophagy
2004 StandoutNobel
Thioredoxin increases the proliferation of human B-cell lines through a protein kinase C-dependent mechanism.
1994
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
2004 Standout
REDOX REGULATION BY INTRINSIC SPECIES AND EXTRINSIC NUTRIENTS IN NORMAL AND CANCER CELLS
2005
Methylarsenicals and Arsinothiols Are Potent Inhibitors of Mouse Liver Thioredoxin Reductase
1999
Measurement of Thioredoxin and Thioredoxin Reductase
2004
Works of John E. Oblong being referenced
The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): Thioredoxin mRNA is elevated in some human tumors
1994
Redox signalling and the control of cell growth and death
1995
Purification of human thioredoxin reductase: Properties and characterization by absorption and circular dichroism spectroscopy
1993
Soluble Chloroplast Enzyme Cleaves preLHCP Made in Escherichia coli to a Mature Form Lacking a Basic N-Terminal Domain
1991
Site-Directed Mutagenesis of Lys36 in Human Thioredoxin: The Highly Conserved Residue Affects Reduction Rates and Growth Stimulation but Is Not Essential for the Redox Protein's Biochemical or Biological Properties
1995
Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues
1994
Base Promoted Rearrangement of Carbonate Esters Derived from Aldehyde Cyanohydrins: Application to the Synthesis of α-Keto Esters
1990
The thioredoxin/thioredoxin reductase redox system and control of cell growth.
1994
Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin.
1994
Identification of two structurally related proteins involved in proteolytic processing of precursors targeted to the chloroplast.
1992
A chloroplast processing enzyme involved in precursor maturation shares a zinc-binding motif with a recently recognized family of metalloendopeptidases.
1995
Loss of efficient import and thylakoid insertion due to N- and C-terminal deletions in the light-harvesting chlorophyll a/b binding protein.
1990