Citation Impact
Citing Papers
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
2013 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
2011
AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
2007
The role of dynamic conformational ensembles in biomolecular recognition
2009 Standout
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis
2003
Ideas about pain, a historical view
2006
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Oligomerization and fibril assembly of the amyloid-β protein
2000
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to Lysosomes versusRecycling
1999
Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
2006
Rapid induction of Alzheimer A beta amyloid formation by zinc
1994 Science
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Primary afferent tachykinins are required to experience moderate to intense pain
1998 Nature
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Alternative splicing in individual aplysia neurons generates neuropeptide diversity
1987 StandoutNobel
Determination of the Amino Acid Residue Involved in [3H]β-Funaltrexamine Covalent Binding in the Cloned Rat µ Opioid Receptor
1996
Galectin-1: a small protein with major functions
2006
Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain
2010
Circulating amyloid-β peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions
2002
Chemical Cross-linking and Mass Spectrometry for Protein Structural Modeling
2003
Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-β aggregation
2001
NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque‐competence, Aβ(1–40)ox and Aβ(1–42)ox
2001 StandoutNobel
Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization
2004
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
2004 Standout
Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases
2005
Direct Observation of Aβ Amyloid Fibril Growth and Inhibition
2004
Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord
2006
Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.
1998
Peptide‐Based Inhibitors of Amyloid Assembly
2006
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver
2006
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
A Molecular Model of Alzheimer Amyloid β-Peptide Fibril Formation
1999
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Alzheimer’s amyloid fibrils: structure and assembly
2000
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Amyloid β-Protein Fibrillogenesis
1997
Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability
2002 Standout
Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier
2000
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Aβ and perlecan in rat brain: glial activation, gradual clearance and limited neurotoxicity
2000
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Identification and characterization of key kinetic intermediates in amyloid β-protein fibrillogenesis11Edited by F. Cohen
2001
Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease
2002
Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier
1997
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease
2009
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
A novelβ‐sheet breaker, RS‐0406, reverses amyloidβ‐induced cytotoxicity and impairment of long‐term potentiationin vitro
2002
Stereoselective Synthesis of a Topologically Chiral Molecule: The Trefoil Knot
2004 StandoutNobel
Oligomerization of β-amyloid of the Alzheimer’s and the Dutch-cerebral-haemorrhage types
2000
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
2011 Standout
Quantifying Amyloid β-Peptide (Aβ) Aggregation Using the Congo Red-Aβ (CR–Aβ) Spectrophotometric Assay
1999
Cerebral amyloid angiopathy in the elderly
2011
A quantitative study of neurons which express neurokinin-1 or somatostatin sst2a receptor in rat spinal dorsal horn
1998
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
1985 StandoutScienceNobel
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
1999
Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of β-amyloid peptide
2000
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
1999
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Topological stereochemistry
1985
Stereocontrolled synthesis of 2,5-linked bistetrahydrofurans via the triepoxide cascade reaction
1986
Molecular basis for amyloid fibril formation and stability
2005
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing
1984 Nature
Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans.
1999
Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System
2006
Comparison of spatial firing characteristics of units in dorsal and ventral hippocampus of the rat
1994
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
2005 StandoutScience
3D structure of Alzheimer's amyloid-β(1–42) fibrils
2005 Standout
Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
1989 StandoutScienceNobel
Sequence analysis of cloned cDNA for rat substance P precursor: Existence of a third substance P precursor
1986
Selective Perhydroxylation of Squalene: Taming the Arithmetic Demon
1993 StandoutScienceNobel
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988 StandoutNobel
Reduced fear expression after lesions of the ventral hippocampus
2002 StandoutNobel
Chemical space as a source for new drugs
2010
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Vanilloid (Capsaicin) Receptors and Mechanisms
1999 Standout
CD36 Mediates the Innate Host Response to β-Amyloid
2003
Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor
1997 Science
Knots and graphs in chemistry
1998
Activation of the beta 2-adrenergic receptor promotes growth and differentiation in thyroid cells.
1989 StandoutNobel
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.
1987 StandoutNobel
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain‐derived synaptic plasticity‐disrupting Aβ
2011
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
Molecular Borromean Rings
2004 StandoutScienceNobel
Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease
2011
Open Problems in Chemical Topology
2008
Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis
2016 StandoutNobel
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.
1987 StandoutNobel
Targeting Cell Surface Receptors with Ligand-Conjugated Nanocrystals
2002
Designed amyloid fibers as materials for selective carbon dioxide capture
2013 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Interlacing molecular threads on transition metals: catenands, catenates, and knots
1990
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Inhibitors of Amyloid Toxicity Based on β-sheet Packing of Aβ40 and Aβ42
2006
Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice
2002
Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting
1998
Finite Scale of Spatial Representation in the Hippocampus
2008 StandoutScienceNobel
Stimulation of connective tissue cell growth by substance P and substance K
1985 Nature
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release
2017 StandoutNobel
Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid
2003
Spatial learning with a minislab in the dorsal hippocampus.
1995 StandoutNobel
Spatial Representation in the Entorhinal Cortex
2004 StandoutScienceNobel
Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
1998
Works of John E. Maggio being referenced
Stereochemical specificity of Alzheimer's disease ?-peptide assembly
1999
Intra-arterial infusion of [125l]Aβ 1–40 labels amyloid deposits in the aged primate brain in vivo
1996
Zinc‐Induced Aggregation of Human and Rat β‐Amyloid Peptides In Vitro
1996
Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma
1996
[23] Deposition of soluble amyloid-β onto amyloid templates: With application for the identification of amyloid fibril extension inhibitors
1999
Aβ deposition inhibitor screen using synthetic amyloid
1997
1H NMR of A.beta. Amyloid Peptide Congeners in Water Solution. Conformational Changes Correlate with Plaque Competence
1995
Proteomic analysis of the reactive phenotype of astrocytes following endothelin‐1 exposure
2003
Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide
1993
Mapping Peptide-binding Domains of the Substance P (NK-1) Receptor from P388D 1 Cells with Photolabile Agonists
1995
Substance P receptors: Localization by light microscopic autoradiography in rat brain using [3H]SP as the radioligand
1984
Rearrangement of a geometrically restricted triepoxide to the first topologically nonplanar molecule: a reaction path elucidated by using oxygen isotope effects on carbon-13 chemical shifts
1981
Photoaffinity Cross-Linking of Alzheimer's Disease Amyloid Fibrils Reveals Interstrand Contact Regions between Assembled β-Amyloid Peptide Subunits
2001
Alzheimer's Disease Amyloid Propagation by a Template-Dependent Dock-Lock Mechanism
2000
In VitroGrowth of Alzheimer's Disease β-Amyloid Plaques Displays First-Order Kinetics†
1996
Point Substitution in the Central Hydrophobic Cluster of a Human β-Amyloid Congener Disrupts Peptide Folding and Abolishes Plaque Competence
1996
Oligomerization of Endogenous and Synthetic Amyloid β-Protein at Nanomolar Levels in Cell Culture and Stabilization of Monomer by Congo Red
1998
Deposition of Monomeric, Not Oligomeric, Aβ Mediates Growth of Alzheimer's Disease Amyloid Plaques in Human Brain Preparations
1999
Pharmacological characterisation of a novel tachykinin isolated from mammalian spinal cord
1984
Zinc and Alzheimer's Disease
1995 Science
Receptor Endocytosis and Dendrite Reshaping in Spinal Neurons After Somatosensory Stimulation
1995 Science
Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo
1998
Synthesis of the first topologically non-planar molecule
1981