Citation Impact
Citing Papers
The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells
2009
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling
2015
Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks
2009
Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy
2008
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
2012 Standout
Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases
2011
Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
2013 Standout
Small-Vessel Vasculitis
1997 Standout
C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation
2012 Standout
Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis
2015
Strategies for the inhibition of serine proteases
2001
CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
2012 Standout
Anti-neutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential
1994
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
2015
2‐Iodoxybenzoic Acid—A Simple Oxidant with a Dazzling Array of Potential Applications
2011
Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs
2007
Two to Tango: Regulation of Mammalian Iron Metabolism
2010 Standout
Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
2001
Graves' Ophthalmopathy
2010 Standout
[31] Isocoumarin inhibitors of serine peptidases
1994
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage
2011
Novel Mechanism of Inhibition of Elastase by β-Lactams Is Defined by Two Inhibitor Crystal Complexes
1999
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
2018 Standout
Mutational Analysis of S12 Protein and Implications for the Accuracy of Decoding by the Ribosome
2007
A short guide for molecular dynamics simulations of RNA systems
2008
Cardiovascular Complications of Cancer Therapy
2009
The Keap1–Nrf2 protein–protein interaction: A suitable target for small molecules
2017
A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes
2008
Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM
2009 StandoutNobel
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
New metal complexes of 4-methyl-7-hydroxycoumarin sodium salt and their pharmacological activity
2001
Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase
2000
Targeting DNA topoisomerase II in cancer chemotherapy
2009 Standout
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
Metabotropic Glutamate Receptor 1 Expression and Its Polymorphic Variants Associate with Breast Cancer Phenotypes
2013
Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
2015
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
Rates of thrombin acylation and deacylation upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylating agents
1995
Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactions
2015
The Thyrotropin Receptor in Graves' Disease
2007
Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development
2010
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Palladium-catalyzed N-arylation of O-methylamidoximes
2002
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis
2014
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM
2008 StandoutNobel
Chemical Routes for the Transformation of Biomass into Chemicals
2007 Standout
2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase
1999
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009 Standout
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Molecular Dynamics Study of the Ribosomal A-Site
2008
Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction
2015
Phosphine Organocatalysis
2018 Standout
Identification of Non-Electrophilic Nrf2 Activators from Approved Drugs
2017
Comparative Analysis of Haemostatic Proteinases: Structural Aspects of Thrombin, Factor Xa, Factor IXa and Protein C
1997
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists
2004
Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
2011 Standout
Electrophilicity Index
2006 Standout
The mechanism of topoisomerase I poisoning by a camptothecin analog
2002
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
The Efficacy of Topoisomerase II-Targeted Anticancer Agents Reflects the Persistence of Drug-Induced Cleavage Complexes in Cells
2008
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Triphenylphosphine-Mediated Synthesis of theE/ZIsomers of Methyl 6-(1,2-Di(methoxycarbonyl))-8-(ethyl Carbamoylformyl)-2-oxo-2H-chromene-4-carboxylate
2006
Palladium‐Catalyzed C3 or C4 Direct Arylation of Heteroaromatic Compounds with Aryl Halides by CH Bond Activation
2009
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Architecture and function of metallopeptidase catalytic domains
2013
Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents
1998
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Multiple binding modes of a small molecule to human Keap1 revealed by X‐ray crystallography and molecular dynamics simulation
2015
6-Substituted 2-Oxo-2H-1-benzopyran-3-carboxylic Acid as a Core Structure for Specific Inhibitors of Human Leukocyte Elastase
1999
Protease Inhibitors: Current Status and Future Prospects
2000
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
TRIPHENYPHOSPHINE-MEDIATED EFFICIENT SYNTHESIS OF FUNCTIONALIZED 2-OXO-2H-CHROMENES
2004
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
2014
In Vitro Selection of Functional Nucleic Acids
1999 StandoutNobel
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Advances in Copper Complexes as Anticancer Agents
2013 Standout
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis
2016
Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor
2015
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases
2018
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)
2017
Highly Potent Irreversible Inhibitors of Neutrophil Elastase Generated by Selection from a Randomized DNA−Valine Phosphonate Library
1997
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.
1995
Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions
2016
Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor
2015
Works of John E. Kerrigan being referenced
6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism-based inhibitors of human leukocyte elastase
2000
Coupling of Drug Protonation to the Specific Binding of Aminoglycosides to the A Site of 16S rRNA: Elucidation of the Number of Drug Amino Groups Involved and their Identities
2003
Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes
2010
Mechanism-Based Isocoumarin Inhibitors for Human Leukocyte Elastase. Effect of the 7-Amino Substituent and 3-Alkoxy Group in 3-Alkoxy-7-amino-4-chloroisocoumarins on Inhibitory Potency
1995
Model of Glycoprotein Hormone Receptor Ligand Binding and Signaling
2004
Substrate and inhibitor studies on proteinase 3
1992
Models of Glycoprotein Hormone Receptor Interaction
2005
Thermodynamics of aminoglycoside–rRNA recognition
2003
Follitropin receptors contain cryptic ligand binding sites
2006
Mechanism-Based Isocoumarin Inhibitors for Blood Coagulation Serine Proteases. Effect of the 7-Substituent in 7-Amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on Inhibitory and Anticoagulant Potency
1994
Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity
2004
A Serine Proteinase Inactivator Inhibits Chondrocyte-Mediated Cartilage Proteoglycan Breakdown Occurring in Response to Proinflammatory Cytokines
1998
Inhibition of Porcine Pancreatic Elastase by 7-Substituted 4-Chloro-3-Ethoxyisocoumarins: Structural Characteristics of Modeled Noncovalent Complexes Relate to the Measured Inhibition Kinetics
1993
Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction
2013
Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles
2006
Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity
2007
A Structural Model for the Ternary Cleavable Complex Formed between Human Topoisomerase I, DNA, and Camptothecin
2001
Anti- Pneumocystis Activities of Aromatic Diamidoxime Prodrugs
1998
Topoisomerase IIβ–Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane
2007