Citation Impact
Citing Papers
Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β
2016
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS
2019 Science
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Alpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
2019 Standout
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
q -gram based database searching using a suffix array (QUASAR)
1999
The diverse and expanding role of mass spectrometry in structural and molecular biology
2016
Requirement of JNK-Mediated Phosphorylation for Translocation of Group IVA Phospholipase A2 to Phagosomes in Human Macrophages
2009
Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis
2008
Membrane curvature regulates the spatial distribution of bulky glycoproteins
2022 StandoutNobel
Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
2014
A Visualizable Chain‐Terminating Inhibitor of Glycosaminoglycan Biosynthesis in Developing Zebrafish
2014 StandoutNobel
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
2020 StandoutNobel
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase A2
2009
The PI3K/AKT Pathway as a Target for Cancer Treatment
2015
Phospholipase A2 subclasses in acute respiratory distress syndrome
2009
PI3Kδ and primary immunodeficiencies
2016
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Necroptosis and its role in inflammation
2015 StandoutNature
Applications of Mass Spectrometry to Lipids and Membranes
2011
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
PI3K signalling in inflammation
2014
A compendium of kinetic modulatory profiles identifies ferroptosis regulators
2021
Complex transcriptional modulation with orthogonal and inducible dCas9 regulators
2016
Ulcerative Colitis
2011 Standout
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA
2018
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force
2010
Phospholipase A2 inhibition and atherosclerotic vascular disease: prospects for targeting secretory and lipoprotein-associated phospholipase A2 enzymes
2010
Hallmarks of aging: An expanding universe
2023 Standout
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Extracellular phospholipases in atherosclerosis
2010
Τhe role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma
2009
Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions
2015
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
Autophagy-Independent Functions of the Autophagy Machinery
2019
An ionizable lipid toolbox for RNA delivery
2021 StandoutNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Future Role for Selective Phospholipase A2 Inhibitors in the Prevention of Atherosclerotic Cardiovascular Disease
2009
Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues
2015 StandoutNobel
Mechanically Activated Ion Channels
2015 StandoutNobel
Regulation of mTORC1 by PI3K signaling
2015
1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase
2009
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Novel bioactive glycerol-based lysophospholipids: New data – New insight into their function
2012
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Lipoprotein-associated phospholipase A2 and atherosclerosis
2009
Mechanism of Intracellular cAMP Sensor Epac2 Activation
2011
Measuring the multifaceted roles of mucin-domain glycoproteins in cancer
2022 StandoutNobel
Revealing the human mucinome
2022 StandoutNobel
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
2009
Combination Therapy of an Inhibitor of Group VIA Phospholipase A2 with Paclitaxel Is Highly Effective in Blocking Ovarian Cancer Development
2011
Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death
2010
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
Enantioselective Synthesis of β,γ‐Unsaturated α‐Fluoroesters Catalyzed by N‐Heterocyclic Carbenes
2012
Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor
2010
Gastric cancer
2020 Standout
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
2014
Membrane lipid composition differentially modulates the function of human plasma platelet activating factor-acetylhydrolase
2010
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
Secretory phospholipase A2: A multifaceted family of proatherogenic enzymes
2009
Phospholipase A2inhibitors as potential therapeutic agents for the treatment of inflammatory diseases
2009
The PI3K Pathway in Human Disease
2017 Standout
Biology of Platelet-activating Factor Acetylhydrolase (PAF-AH, Lipoprotein Associated Phospholipase A2)
2008
Genetics of ulcerative colitis
2010
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease
2011
Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans
2014 StandoutNobel
Design, Synthesis, and Biological Evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as New Indole-Based Cytosolic Phospholipase A2α Inhibitors
2014
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances
2012
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis
2020 StandoutNobel
The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
2013 Standout
Lipoprotein-Associated Phospholipase A2 Interacts with Phospholipid Vesicles via a Surface-Disposed Hydrophobic α-Helix
2011
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2− Metastatic Breast Cancer
2016
Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice
2010
Metabolic reprogramming and cancer progression
2020 StandoutScience
Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes
2015 Standout
Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy
2017
Molecular Docking and 3D-QSAR CoMFA Studies on Indole Inhibitors of GIIA Secreted Phospholipase A2
2010
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Liquid biopsies to track trastuzumab resistance in metastatic HER2-positive gastric cancer
2018
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
2010
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
2016
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
2016
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
2018
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release
2017 StandoutNobel
Works of John E. Burke being referenced
Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1
2017
Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α
2011
Localizing the Membrane Binding Region of Group VIA Ca2+-independent Phospholipase A2 Using Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry
2009
A Phospholipid Substrate Molecule Residing in the Membrane Surface Mediates Opening of the Lid Region in Group IVA Cytosolic Phospholipase A2
2008
Phospholipase A2 structure/function, mechanism, and signaling
2008
PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control
2013
Synergy in activating class I PI3Ks
2015
Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases
2011
Phospholipase A2 Biochemistry
2008
Biological Evaluation of d 2 , an Algorithm for High-Performance Sequence Comparison
1994
Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS)
2012
Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention
2017
Calcium Binding Rigidifies the C2 Domain and the Intradomain Interaction of GIVA Phospholipase A2 as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
2008
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity
2015
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
2015 Science
Glycoprotein biosynthesis in animal cells grown in suspension culture. Assembly of lipid-linked saccharides and formation of protein-bound ‘high-mannose’ oligosaccharides
1981
Location of Inhibitors Bound to Group IVA Phospholipase A2 Determined by Molecular Dynamics and Deuterium Exchange Mass Spectrometry
2009
Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2
2010
Interaction of Group IA Phospholipase A2 with Metal Ions and Phospholipid Vesicles Probed with Deuterium Exchange Mass Spectrometry
2008
Recognition of protein-linked glycans as a determinant of peptidase activity
2017
G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness
2012
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α ( PIK3CA )
2012
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)
2013