Citation Impact
Citing Papers
Interleukin‐6 Activates Signal Transducer and Activator of Transcription and Mitogen‐Activated Protein Kinase Signal Transduction Pathways and Induces De Novo Protein Synthesis in Human Neuronal Cells
1999
Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
2003 StandoutScience
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
2006 StandoutScience
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
2005 StandoutScience
The Y chromosome as a battle ground for sexual selection
1999
Inflammation and Alzheimer's disease
2000 Standout
Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment
1997
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials
1997
RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing
2000
Reactive astrocytes: cellular and molecular cues to biological function
1997 Standout
Generation and characterization of a ΔF508 cystic fibrosis mouse model
1995 StandoutNobel
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.
1997
Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain
2014
Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry
2012 StandoutNobel
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
2002
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
An abundance of X-linked genes expressed in spermatogonia
2001
Cytokines and Chemokines as Mediators of Protection and Injury in the Central Nervous System Assessed in Transgenic Mice
2002
Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation
2010
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
1998 StandoutNatureNobel
Microdeletions in the Y Chromosome of Infertile Men
1997
RNAi
2000 Standout
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions
1998
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
Vaccinia Virus Late Transcription Is Activated in Vitro by Cellular Heterogeneous Nuclear Ribonucleoproteins
2001
Lessons from Hereditary Colorectal Cancer
1996 Standout
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
2002 Standout
Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11
1996
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
1995
IL-6 as a keystone cytokine in health and disease
2015 Standout
Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity
2000 StandoutNobel
Interleukin-6 expression and regulation in astrocytes
1999
MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos
1996 StandoutNobel
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease
1999
Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology1Published on the World Wide Web on 21 October 1997.1
1998
Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice.
1996
Neurodegeneration and Inflammation
2008
X-inactivation profile reveals extensive variability in X-linked gene expression in females
2005 StandoutNature
Tracking and Elucidating Alphavirus-Host Protein Interactions
2006 StandoutNobel
IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein
1998
Demographic history and linkage disequilibrium in human populations
1997 StandoutNobel
Immunity, Inflammation, and Cancer
2010 Standout
Cytokines in inflammatory brain lesions: helpful and harmful
1996
The origin and function of the mammalian Y chromosome and Y‐borne genes – an evolving understanding
1995
The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men
2001
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
1995 StandoutNobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alphal-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IκB-alpha
1999
IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
1998
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
2004 Standout
Glucocorticoids in Alzheimer??s Disease
1998
Late-Onset Chronic Inflammatory Encephalopathy in Immune-Competent and Severe Combined Immune-Deficient (SCID) Mice with Astrocyte-Targeted Expression of Tumor Necrosis Factor
1998
Alzheimer's Disease
2010 Standout
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
1999
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA–binding protein gene
1995
RNA interference
2002 StandoutNature
Expression of cathepsin G-like and α1-antichymotrypsin-like proteins in reactive astrocytes
1993
Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression
1996
Occurrence of Interleukin‐6 in Cortical Plaques of Alzheimer's Disease Patients May Precede Transformation of Diffuse into Neuritic Plaquesa
1996
Revealing the world of RNA interference
2004 StandoutNatureNobel
Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
1993
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
1992 Standout
Targeted homologous recombination in mammalian cells
1992
Acute-Phase Proteins and Other Systemic Responses to Inflammation
1999 Standout
Molecular mapping of the putative gonadoblastoma locus on the Y chromosome
1995
Physiological and pathological roles of interleukin-6 in the central nervous system
1997
Anemia of Chronic Disease
2005 Standout
The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro
2004 StandoutNobel
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
2016 Standout
NSAIDS inhibit the IL-1β-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2
1997
The M22 antibody identifies highly activated reactive astrocytes responding to central nervous system disease
1996
Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex
1998
Anti-inflammatory substances – a new therapeutic option in Alzheimer's disease
1999
MAMMALS THAT BREAK THE RULES: Genetics of Marsupials and Monotremes
1996
Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6
2002
Serpin Structure, Mechanism, and Function
2002 Standout
Four Evolutionary Strata on the Human X Chromosome
1999 Science
Effect of dexamethasone on elevated cytokine mRNA levels in chemical-induced hippocampal injury
1999
Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population.
1996 StandoutNobel
Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.
1995
A Region Rich in Aspartic Acid, Arginine, Tyrosine, and Glycine (DRYG) Mediates Eukaryotic Initiation Factor 4B (eIF4B) Self-Association and Interaction with eIF3
1996
INFLAMMATION AND ALZHEIMERS DISEASE
2000
Interleukin-6 and risk of cognitive decline
2002
IL-6 transgenic mouse model for extraosseous plasmacytoma
2002
Interleukin‐6 functions in autoimmune encephalomyelitis: a study in gene‐targeted mice
1998
Functional Coherence of the Human Y Chromosome
1997 StandoutScience
Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.
1995
mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm
1997 StandoutNobel
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
2003 StandoutScience
Regional and strain-specific gene expression mapping in the adult mouse brain
2000
Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome.
1995
Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
1997
Intrinsically Disordered Proteins in Human Diseases: Introducing the D2Concept
2008
Sensory Impairments and Delayed Regeneration of Sensory Axons in Interleukin-6-Deficient Mice
1999
Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo
1999
Role of interleukin‐6 and soluble IL‐6 receptor in region‐specific induction of astrocytic differentiation and neurotrophin expression
1999
Review
1995
Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death
2001
Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor
1999
Phosphatidylinositol-3-Kinase Signaling Is Required for Erythropoietin-Mediated Acute Protection Against Myocardial Ischemia/Reperfusion Injury
2004 StandoutNobel
Gene targeting at the human CD4 locus by epitope addition.
1990 Nobel
Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
2003
Correction of a human beta S-globin gene by gene targeting.
1991 StandoutNobel
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Protein structure prediction for the male-specific region of the human Y chromosome
2004 StandoutNobel
Altering mice by homologous recombination using embryonic stem cells.
1994 StandoutNobel
RNAi in C. elegans : Soaking in the Genome Sequence
1998 StandoutScienceNobel
Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.
1998
Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration
2000
Conserved Structures and Diversity of Functions of RNA-Binding Proteins
1994 StandoutScience
Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.
1990
Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries
1995
Nature of the Retrograde Signal from Injured Nerves that Induces Interleukin-6 mRNA in Neurons
1999
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
1997
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
2002 StandoutNobel
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
2000
Works of John D. Inglis being referenced
A Y chromosome gene family with RNA-binding protein homology: Candidates for the azoospermia factor AZF controlling human spermatogenesis
1993
Emk, a protein kinase with homologs in yeast maps to mouse Chromosome 19
1993
Isolation of two cDNAs encoding novel α1-antichymotrypsin-like proteins in a murine chondrocytic cell line
1991
The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.
1991
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
1993
Selection for Precise Chromosomal Targeting of a Dominant Marker by Homologous Recombination
1989 Science