Citation Impact
Citing Papers
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Directed Mutagenesis Alters the Stereochemistry of Catalysis by Isolated Ketoreductase Domains from the Erythromycin Polyketide Synthase
2006
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2005
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2003
RhIII‐ and IrIII‐Catalyzed Asymmetric Transfer Hydrogenation of Ketones in Water
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2003
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1999
The role of distant mutations and allosteric regulation on LovD active site dynamics
2014
High-Throughput Mutagenesis to Evaluate Models of Stereochemical Control in Ketoreductase Domains from the Erythromycin Polyketide Synthase
2006
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2003
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Asymmetric spiroacetalization catalysed by confined Brønsted acids
2012 StandoutNatureNobel
The Hedamycin Locus Implicates a Novel Aromatic PKS Priming Mechanism
2004
A brief tour of myxobacterial secondary metabolism
2008
Optimal Determination of Particle Orientation, Absolute Hand, and Contrast Loss in Single-particle Electron Cryomicroscopy
2003 StandoutNobel
The biosynthetic genes encoding for the production of the dynemicin enediyne core inMicromonospora chersinaATCC53710
2008
Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
2013 StandoutNobel
Alternative modular polyketide synthase expression controls macrolactone structure
2000 Nature
Skipping in a Hybrid Polyketide Synthase
2002
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2‐methyl‐3‐n‐amyl‐pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces
2005
A Type II Polyketide Synthase is Responsible for Anthraquinone Biosynthesis in Photorhabdus luminescens
2007
Protein–Protein Interactions in Multienzyme Megasynthetases
2008
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
2016
Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure
2008
A new enzyme superfamily — the phosphopantetheinyl transferases
1996
Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase
2014
Isoprenoid-like alkylations in polyketide biosynthesis
2008
Structural control of polyketide formation in plant-specific polyketide synthases
2000
Characterization of the Alnumycin Gene Cluster Reveals Unusual Gene Products for Pyran Ring Formation and Dioxan Biosynthesis
2008
Biosynthesis and attachment of novel bacterial polyketide synthase starter units
2001
Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage
2011
Polyketide biosynthesis: a millennium review
2001 Standout
Reversible trapping and reaction acceleration within dynamically self-assembling nanoflasks
2015
Core–shell structured mesoporous silica: a new immobilized strategy for rhodium catalyzed asymmetric transfer hydrogenation
2012
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
2007
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization
2003
Biosynthesis of the Antibiotic Bacillaene, the Product of a Giant Polyketide Synthase Complex of the trans‐AT Family
2007
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
2008
Probing the interactions of an acyl carrier protein domain from the 6‐deoxyerythronolide B synthase
2011
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
2006
Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase
2002
The contentious nature of soil organic matter
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Asymmetric transfer hydrogenation catalysed by hydrophobic dendritic DACH–rhodium complex in water
2006
DNA‐Based Catalytic Enantioselective Michael Reactions in Water
2007 StandoutNobel
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
2000
Context-Dependent Behavior of the Enterocin Iterative Polyketide Synthase
2004
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes
2001
Enantioselective Synthesis of Alcohols and Amines by Iridium‐Catalyzed Hydrogenation, Transfer Hydrogenation, and Related Processes
2013
Transfer Hydrogenation of Ketones Catalyzed by Surface‐Active Ruthenium and Rhodium Complexes in Water
2013
The type I fatty acid and polyketide synthases: a tale of two megasynthases
2007
Aqueous-phase asymmetric transfer hydrogenation of ketones ? a greener approach to chiral alcohols
2007
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
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2006
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation
2011
Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum
2001
Iridium Diamine Catalyst for the Asymmetric Transfer Hydrogenation of Ketones
2011
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
Biosynthesis of fatty acids and related metabolites
1997
Efficient Heterogeneous Asymmetric Transfer Hydrogenation Catalyzed by Recyclable Silica‐Supported Ruthenium Complexes
2005
Asymmetric 1,3-Dipolar Cycloaddition Reactions
1998 Standout
Asymmetric Transfer Hydrogenation of Prochiral Ketones in Aqueous Media with New Water-Soluble Chiral Vicinal Diamine as Ligand
2003
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2008
The novel water-soluble chiral PNNP-type ligand for the enantioselective reduction of ketones in aqueous media
2006
Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Hydrophobic Metal−Amido Complexes in Aqueous Micelles and Vesicles
2005
The Golden Age of Transfer Hydrogenation
2015 Standout
Catalytic Asymmetric Reductive Condensation of N–H Imines: Synthesis of C2‐Symmetric Secondary Amines
2016 StandoutNobel
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Toward green catalytic synthesis—Transition metal-catalyzed reactions in non-conventional media
2007
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Improving Protein Expression, Stability, and Function with ProteinMPNN
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Priming Type II Polyketide Synthases via a Type II Nonribosomal Peptide Synthetase Mechanism
2006
A dynamic combinatorial screen for novel imine reductase activity
2003
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Genetic Contributions to Understanding Polyketide Synthases
1997
Catalytic applications of rhodium complexes containing trialkylphosphines
1996
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis
2003
Synthesis of polymer microspheres functionalized with chiral ligand by precipitation polymerization and their application to asymmetric transfer hydrogenation
2010
First example of asymmetric transfer hydrogenation in water induced by a chiral amino alcohol hydrochloride
2005
Ru(II) Complexes of N-Alkylated TsDPEN Ligands in Asymmetric Transfer Hydrogenation of Ketones and Imines
2009
Biosynthesis of the Antibiotic Bacillaene, the Product of a Giant Polyketide Synthase Complex of the trans‐AT Family
2007
Mechanistic Aspects of the Kharasch Addition Reaction Catalyzed by Organonickel(II) Complexes Containing the Monoanionic Terdentate Aryldiamine Ligand System [C6H2(CH2NMe2)2-2,6-R-4]-
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Hydroamination: Direct Addition of Amines to Alkenes and Alkynes
2008 Standout
Asymmetric Transfer Hydrogenation of Ketones with Bifunctional Transition Metal-Based Molecular Catalysts
2007
The “Reverse-Tethered” Ruthenium (II) Catalyst for Asymmetric Transfer Hydrogenation: Further Applications
2006
Second‐Generation Amino Acid Furanoside Based Ligands from D ‐Glucose for the Asymmetric Transfer Hydrogenation of Ketones
2013
Asymmetric transfer hydrogenation of aromatic ketones catalyzed by the iridium hydride complex under ambient conditions
2004
Biosynthesis of Nonribosomal Peptides
2004
Half-sandwich iridium complexes—Synthesis and applications in catalysis
2008
Biosynthesis of Pentangular Polyphenols: Deductions from the Benastatin and Griseorhodin Pathways
2007
Surfactant-accelerated asymmetric transfer hydrogenation with recyclable water-soluble catalyst in aqueous media
2012
New efficient P,N,O-tridentate ligands for Ru-catalyzed asymmetric transfer hydrogenation
2003
Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase Inhibitors
2018
Aurachin‐Biosynthese im Gram‐negativen Bakterium Stigmatella aurantiaca: Beteiligung einer Typ‐II‐Polyketidsynthase
2007
CO2 Hydrogenation to Formate and Methanol as an Alternative to Photo- and Electrochemical CO2 Reduction
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Dynamic Combinatorial Chemistry
2006 Standout
Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics
2005
Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
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Magnetically Recoverable Nanoparticles: Highly Efficient Catalysts for Asymmetric Transfer Hydrogenation of Aromatic Ketones in Aqueous Medium
2011
N-Heterocyclic Carbenes in Late Transition Metal Catalysis
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THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS
2005
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Fast Time Scale Dynamics of Protein Backbones: NMR Relaxation Methods, Applications, and Functional Consequences
2006
Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula
2004
Ether-tethered Ru(ii)/TsDPEN complexes; synthesis and applications to asymmetric transfer hydrogenation
2011
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Aqueous-phase catalytic oxidation, transfer hydrogenation, reductive amination and hydration reactions
2014
Dissecting the Chain Length Specificity in Bacterial Aromatic Polyketide Synthases using Chimeric Genes
2000
Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
2014 Standout
Imidazolium ion tethered TsDPENs as efficient water-soluble ligands for rhodium catalyzed asymmetric transfer hydrogenation of aromatic ketones
2014
Asymmetric hydrosilylation, transfer hydrogenation and hydrogenation of ketones catalyzed by iridium complexes
2009
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
Highly stereoselective synthesis of mupirocin H
2017
Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases
2004
Polyethylene glycol‐bound Ru catalyst for asymmetric transfer hydrogenation of aromatic ketones in water
2011
Alternative Synthetic Methods through New Developments in Catalysis by Gold
2008 Standout
Confined acids catalyze asymmetric single aldolizations of acetaldehyde enolates
2018 StandoutScienceNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Dynamic Kinetic Resolution of Racemic β-Haloalcohols: Direct Access to Enantioenriched Epoxides
2008 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
DNA-Based Asymmetric Catalysis: Sequence-Dependent Rate Acceleration and Enantioselectivity
2008 StandoutNobel
Artificial metalloenzymes based on biotin-avidin technology for the enantioselective reduction of ketones by transfer hydrogenation
2005
De Novo Determination of Protein Backbone Structure from Residual Dipolar Couplings Using Rosetta
2002 StandoutNobel
Metal-Catalyzed Living Radical Polymerization
2001 Standout
Synthesis, characterization and use of a new tethered Rh(III) complex in asymmetric transfer hydrogenation of ketones
2015
Mechanistic Analysis of a Type II Polyketide Synthase. Role of Conserved Residues in the β-Ketoacyl Synthase−Chain Length Factor Heterodimer
2000
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Swinging Arms and Swinging Domains in Multifunctional Enzymes: Catalytic Machines for Multistep Reactions
2000
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
Unexpectedly fast catalytic transfer hydrogenation of aldehydes by formate in 2-propanol–water mixtures under mild conditions
2014
C-O Bond Formation by Polyketide Synthases
2002 Science
A Family of Active Iridium Catalysts for Transfer Hydrogenation of Ketones
2006
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in “ Streptomyces carzinostaticus ”
2004
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
An Outstanding Catalyst for Asymmetric Transfer Hydrogenation in Aqueous Solution and Formic Acid/Triethylamine.
2006
Production of Polyunsaturated Fatty Acids by Polyketide Synthases in Both Prokaryotes and Eukaryotes
2001 Science
Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis
2009 Standout
Insight into the role of fluorinated dendrimers in ruthenium(II) catalyst for asymmetric transfer hydrogenation: The stabilizing effects from experimental and DFT approach
2014
Transfer hydrogenation reduction of ketones, aldehydes and imines using chelated iridium(III) N-heterocyclic bis-carbene complexes
2004
Varying the ratio of formic acid to triethylamine impacts on asymmetric transfer hydrogenation of ketones
2012
Growth and division of active droplets provides a model for protocells
2016
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Proton-Coupled Electron Transfer
2012 Standout
Self-Assembly of Colloidal Nanocrystals: From Intricate Structures to Functional Materials
2016 Standout
1,3-dipolar cycloaddition reactions of levoglucosenone
1992
Polyketide Chain Length Control by Chain Length Factor
2003
Synthesis of Enantiopure Iridium(I) and Iridium(III) Pybox Complexes and Their Application in the Asymmetric Transfer Hydrogenation of Ketones
2008
Works of John Crosby being referenced
Tandemly Duplicated Acyl Carrier Proteins, Which Increase Polyketide Antibiotic Production, Can Apparently Function Either in Parallel or in Series
2004
An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein
2008
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determinationElectronic supplementary information (ESI) available: LCMS spectra and detailed experimental procedures for all reported experiments. See http://www.rsc.org/suppdata/cc/b3/b300847a/
2003
Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster
2005
Post‐translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins
1997
The Crystal Structure of the actIII Actinorhodin Polyketide Reductase
2004
A chain initiation factor common to both modular and aromatic polyketide synthases
1999 Nature
Acylation of Streptomyces type II polyketide synthase acyl carrier proteins
1998
Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2)
2009
Shift to Pseudomonic Acid B Production in P. fluorescens NCIMB10586 by Mutation of Mupirocin Tailoring Genes mupO, mupU, mupV, and macpE
2005
Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production
2011
Mutational Analysis Reveals That All Tailoring Region Genes Are Required for Production of Polyketide Antibiotic Mupirocin by Pseudomonas fluorescens
2007
Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens
2007
Catalytic self-acylation of type II polyketide synthase acyl carrier proteins
1998
MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor
1998
Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer–nucleotide coacervate droplets
2012
In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the “Leaky Hosepipe” Mechanism
2008
Conserved secondary structure in the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) and the fatty acid synthase acyl carrier protein from Escherichia coli
1996
The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs
2003
Structure and Malonyl CoA-ACP Transacylase Binding of Streptomyces coelicolor Fatty Acid Synthase Acyl Carrier Protein
2009
Kinetic and Mechanistic Analysis of the Malonyl CoA:ACP Transacylase from Streptomyces coelicolor Indicates a Single Catalytically Competent Serine Nucleophile at the Active Site
2002
Nitrile sulphides. Part 1. 1,3-Dipolar cycloaddition to carbonyl groups activated by trihaloalkyl substituents; synthesis and crystal structure of 1,3,4-oxathiazoles
1981
Solution Structure of the Actinorhodin Polyketide Synthase Acyl Carrier Protein from Streptomyces coelicolor A3(2),
1997
Streptomyces coelicolor phosphopantetheinyl transferase: a promiscuous activator of polyketide and fatty acid synthase acyl carrier proteins
2002
Solution Structure of an Acyl Carrier Protein Domain from a Fungal Type I Polyketide Synthase,
2010
Self-Malonylation Is an Intrinsic Property of a Chemically Synthesized Type II Polyketide Synthase Acyl Carrier Protein,
2005
Bulgecin A: a novel inhibitor of binuclear metallo-β-lactamases
2005
Does the rhodium-catalysed addition of perhaloalkanes to alkenes (i.e. the Kharasch reaction) proceed via an oxidative-addition mechanism?: the crystal structure of RhBr(CCl3)Cl(CO)(PMe3)2
1991
Solution Structure and Dynamics of Oxytetracycline Polyketide Synthase Acyl Carrier Protein from Streptomyces rimosus,
2003
Efficient rhodium and iridium-catalysed asymmetric transfer hydrogenation using water-soluble aminosulfonamide ligands
2001
Polyketide synthase acyl carrier proteins from Streptomyces: expression in Escherichia coli, purification and partial characterisation
1995