John Child

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease

Congenital Heart Disease in the General Population

2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease

2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary

2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary

Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

So hard to say goodbye: transition from paediatric to adult cardiology care

Caring for adults with congenital cardiac disease: successes and challenges for 2007 and beyond

Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population

Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis

Use of Low Molecular Weight Heparin in Pregnant Women With Mechanical Heart Valves

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure

Iron Overload Cardiomyopathy

Beyond Cholesterol

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

Outcomes in Adults With Bicuspid Aortic Valves

Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves

Minimally modified low density lipoprotein is biologically active in vivo in mice.

Triiodothyronine repletion in infants during cardiopulmonary bypass for congenital heart disease

Dietary Antioxidants and Cardiovascular Disease

Mapping of a First Locus for Autosomal Dominant Myxomatous Mitral-Valve Prolapse to Chromosome 16p11.2-p12.1

Arrhythmias in mitral valve prolapse: Relation to anterior mitral leaflet thickening, clinical variables, and color Doppler echocardiographic parameters

Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.

Thyroid Hormone and the Cardiovascular System

Usefulness of triiodothyronine (T3) treatment after surgery for complex congenital heart disease in infants and children

Identification of High-Risk and Low-Risk Subgroups of Patients with Mitral-Valve Prolapse

The Bicuspid Aortic Valve

Aortic Stenosis

Regulation of Ferroptotic Cancer Cell Death by GPX4

A role of PIEZO1 in iron metabolism in mice and humans

Effects of exercise on transmitral gradient and pulmonary artery pressure in patients with mitral stenosis or a prosthetic mitral valve: A doppler echocardiographic study

Long-Term Prognostic Impact of Dobutamine Stress Echocardiography in Patients With Kawasaki Disease and Coronary Artery Lesions

Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.

Bicuspid Aortic Valves Are Associated With Aortic Dilatation Out of Proportion to Coexistent Valvular Lesions

A Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 11p15.4

Echocardiographic Findings in Autosomal Dominant Polycystic Kidney Disease

Infective endocarditis in congenital heart disease

Current patterns of infective endocarditis in congenital heart disease

Genetic Basis for Congenital Heart Defects: Current Knowledge

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension

Identification of the haemoglobin scavenger receptor

Atherosclerosis — An Inflammatory Disease

Inflammation in atherosclerosis

Pregnancy in Association with Mitral Valve Prolapse

Clinical information determines the impact of transesophageal echocardiography on the diagnosis of infective endocarditis by the Duke criteria

Progress and challenges in translating the biology of atherosclerosis

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

Inflammation, Atherosclerosis, and Coronary Artery Disease

Atherosclerosis

Arterial Metabolism of Lipoproteins in Relation to Atherogenesis

Left Ventricular Dilatation and the Risk of Congestive Heart Failure in People without Myocardial Infarction

22q11.2 deletion syndrome

Risk of complications during pregnancy in women with congenital aortic stenosis

Malignant Ventricular Arrhythmias in Patients with Mitral Valve Prolapse and Mild Mitral Regurgitation

Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association

Role of oxidized low density lipoprotein in atherogenesis.

The pathogenesis of atherosclerosis: a perspective for the 1990s

Chronic thromboembolic pulmonary hypertension

Prevalence of Patent Foramen Ovale in Patients with Stroke

Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group

Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice

Thyroid Hormone Metabolism in Patients with Congestive Heart Failure: The Low Triiodothyronine State

ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography

Diagnosis and Management of the Cardiac Amyloidoses

Atherosclerosis: Scavenger cell receptor shared

HIF-1α is required for development of the sympathetic nervous system

Best Practices in Managing Transition to Adulthood for Adolescents With Congenital Heart Disease: The Transition Process and Medical and Psychosocial Issues

Enhanced procoagulatory activity (PCA) of human monocytes/macrophages after in vitro stimulation with chemically modified LDL

Prevention of Bacterial Endocarditis

Hemodynamics in the Cardiac Catheterization Laboratory of the 21st Century

Pulmonary Vascular Disease in Adults With Congenital Heart Disease

Lipoproteins of the extravascular space: enhanced macrophage degradation of low density lipoproteins from interstitial inflammatory fluid

High-affinity uptake and degradation of acetylated low density lipoprotein by confluent human vascular endothelial cells

Clinical and Pathophysiological Implications of a Bicuspid Aortic Valve

Atherosclerosis: Basic Mechanisms

New Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 13

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

Lipoproteins and atherosclerosis. A look back and a look ahead.

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

INTERACTIONS OF PLASMA LIPOPROTEINS WITH ENDOTHELIAL CELLS*

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

Regulation of Plasma Cholesterol by Lipoprotein Receptors

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

Failure to Prevent Progressive Dilation of Ascending Aorta by Aortic Valve Replacement in Patients With Bicuspid Aortic Valve: Comparison With Tricuspid Aortic Valve

PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Enhanced macrophage uptake of low density lipoprotein after self-aggregation.

The LDL Receptor Defect in Familial Hypercholesterolemia: Implications for Pathogenesis and Therapy

Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein.

Nongenomic Steroid Action: Controversies, Questions, and Answers

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages

Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

Recommendations for physical activity, recreation sport, and exercise training in paediatric patients with congenital heart disease: a report from the Exercise, Basic & Translational Research Section of the European Association of Cardiovascular Prevention and Rehabilitation, the European Congenital Heart and Lung Exercise Group, and the Association for European Paediatric Cardiology

Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

The Yin and Yang of Oxidation in the Development of the Fatty Streak

ACC/AHA clinical competence statement on echocardiography11When citing this document, the American College of Cardiology, the American Heart Association, and the American College of Physicians–American Society of Internal Medicine would appreciate the following citation format: Quiñones MA, Douglas PS, Foster E, Gorcsan J, Lewis JF, Pearlman AS, Rychik J, Salcedo EE, Seward J, Stevenson JG, Thys DM, Weitz HH, and Zoghbi WA. ACC/AHA clinical competence statement on echocardiography: a report of the American College of Cardiology/American Heart Association/American College of Physicians–American Society of Internal Medicine Task Force on Clinical Competence (Committee on Echocardiography). J Am Coll Cardiol 2003;41:687–708.22This document was approved by the American College of Cardiology Board of Trustees in December 2002 and the American Heart Association Science Advisory and Coordinating Committee in November 2002.**Address for Reprints: This document is available on the Web sites of the American College of Cardiology (www.acc.org), the American Heart Association (www.americanheart.org), the American Society of Echocardiography (http://asecho.org), and the Society of Pediatric Echocardiography (www.sopeonline.com). Reprints of this document may be purchased for $5.00 each by calling 1-800-253-4636 or by writing to the American College of Cardiology, Resource Center, 9111 Old Georgetown Road, Bethesda, Maryland 20814-1699.

Chronic Thromboembolic Pulmonary Hypertension

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

Enhanced macrophage degradation of biologically modified low density lipoprotein.

A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

Atherogenic Hyperlipoproteinemia: The Cellular and Molecular Biology of Plasma Lipoproteins Altered by Dietary Fat and Cholesterol

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Ischemic Mitral Regurgitation on the Threshold of a Solution

Platelet secretory products inhibit lipoprotein metabolism in macrophages

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate

Parent- Versus Child-Reported Functional Health Status After the Fontan Procedure

Probucol prevents lipid storage in macrophages

Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy.

Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching.

Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

A low density lipoprotein-sized particle isolated from human atherosclerotic lesions is internalized by macrophages via a non-scavenger-receptor mechanism.

Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100.

Infective Endocarditis in Children With Congenital Heart Disease

Murine macrophage tumors are a source of a 260,000-dalton acetyl-low density lipoprotein receptor.

2015 ESC Guidelines for the management of infective endocarditis

George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components.

The effect of proteoglycans, collagen and lysyl oxidase on the metabolism of low density lipoprotein by macrophages

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits.

The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins.

Low density lipoprotein undergoes oxidative modification in vivo.

Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism.

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

Independent Pathways for Secretion of Cholesterol and Apolipoprotein E by Macrophages

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Presence of a modified low density lipoprotein in humans.

Isolation, purification, and characterization of a lipoprotein containing apo B from the human aorta

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

Immune mechanisms in atherosclerosis.

Immune Mechanisms in Atherosclerosis

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor.

Probucol inhibits oxidative modification of low density lipoprotein.

Determinants of the Degree of Functional Mitral Regurgitation in Patients With Systolic Left Ventricular Dysfunction

Stimulation of cholesteryl ester synthesis in macrophages by extracts of atherosclerotic human aortas and complexes of albumin/cholesteryl esters.

Antiinflammatory Properties of HDL

Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits.

Neurodevelopmental Outcomes in Children With Congenital Heart Disease: Evaluation and Management

Crystal and Molecular Structure of a Collagen-Like Peptide at 1.9 Å Resolution

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

RISKS FOR AND PREVENTION OF INFECTIVE ENDOCARDITIS

Impact of left ventricular cavity size on survival in advanced heart failure

Report of the National Heart, Lung, and Blood Institute Working Group on Research in Adult Congenital Heart Disease

Incidence of thrombus formation on the CardioSEAL and the Amplatzer interatrial closure devices

Health-related quality of life: A closer look at related research in patients who have undergone the Fontan operation over the last decade

Sustained reduction in valvular regurgitation and atrial volumes with tailored vasodilator therapy in advanced congestive heart failure secondary to dilated (ischemic or idiopathic) cardiomyopathy

ROLE OF TRANSTHORACIC AND TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN DIAGNOSIS AND MANAGEMENT OF INFECTIVE ENDOCARDITIS

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive Heart Failure

Proximal pulmonary arterial and intrapulmonary radiologic features of Eisenmenger syndrome and primary pulmonary hypertension

Prognostic value of dobutamine stress echocardiography in predicting cardiac events in patients with known or suspected coronary artery disease

INFECTIVE ENDOCARDITIS IN CONGENITAL HEART DISEASE

Eisenmenger syndrome in adults

Primary hemochromatosis: Anatomic and physiologic characteristics of the cardiac ventricles and their response to phlebotomy

New guidelines for the clinical diagnosis of mitral valve prolapse

ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease

Clinical and epidemiologic issues in mitral valve prolapse: Overview and perspective

ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: Executive Summary

Comparison of two-dimensional and doppler echocardiography and intracardiac hemodynamics for quantification of mitral stenosis

ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease

Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages

ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: Executive Summary

Structural Abnormalities of Great Arterial Walls in Congenital Heart Disease

Echocardiographic Manifestations of Infiltrative Cardiomyopathy

Predictability of mitral regurgitation detected by Doppler echocardiography in patients referred for cardiac transplantation

Left Ventricular Outflow Obstruction

Task Force 3: workforce description and educational requirements for the care of adults with congenital heart disease

Reassessment of echocardiographic criteria for diagnosis of mitral valve prolapse