Citation Impact
Citing Papers
Visualizing enveloping layer glycans during zebrafish early embryogenesis
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2004 StandoutScienceNobel
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2012 StandoutScienceNobel
folded gastrulation , cell shape change and the control of myosin localization
2005 Nobel
The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans
2006
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
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Hallmarks of Cancer: The Next Generation
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Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria
2010
Differential range and activity of various forms of the Hedgehog protein
2005
Hedgehog Activates Fused through Phosphorylation to Elicit a Full Spectrum of Pathway Responses
2011
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2008 Standout
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2002
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Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus
2000
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
1999 Standout
Adrenergic receptors mediate changes in c-fos mRNA levels in brain
1989
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
2001
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Chronic Electroconvulsive Seizures Down–Regulate Expression of the Immediate‐Early Genes c‐fos and c‐jun in Rat Cerebral Cortex
1990
Immediate-early genes, kindling and long-term potentiation
1989
Planar polarized actomyosin contractile flows control epithelial junction remodelling
2010 Nature
Hedgehog and Patched in Neural Development and Disease
1998
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification
2002
fos-associated cellular p39 is related to nuclear transcription factor AP-1
1988
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
2003
Trans-repression of the mouse c-fos promoter: A novel mechanism of fos-mediated trans-regulation
1989
New light on Myc and Myb. Part I. Myc.
1990
Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements
1995
Hedgehog signalling in the mouse requires intraflagellar transport proteins
2003 StandoutNature
Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun
1991 Standout
Control of Shh activity and signaling in the neural tube
2000
Dynamic imine chemistry
2012 StandoutNobel
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Distinct Phosphorylations on Kinesin Costal-2 Mediate Differential Hedgehog Signaling Strength
2012
Sec15, a Component of the Exocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Organ Precursors
2005
The language of covalent histone modifications
2000 StandoutNature
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
2010
Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus
1999
The hedgehog signaling network
2003
Modulation of Hedgehog target gene expression by the Fused serine–threonine kinase in wing imaginal discs
1998
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
2003
Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
2010
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
1991 Standout
Identification of a Tetrameric Hedgehog Signaling Complex
2000
Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
2001
Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord
1989
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
2005
The Directional Preference of Kinesin Motors Is Specified by an Element outside of the Motor Catalytic Domain
1997
Hedgehog Signal Transduction in the Posterior Compartment of the Drosophila Wing Imaginal Disc
2000
A freely diffusible form of Sonic hedgehog mediates long-range signalling
2001 Nature
Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2
2003
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
Vertebrate Homologs of Drosophila Suppressor of Fused Interact with the Gli Family of Transcriptional Regulators
1999
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor
1997
Rho GTPases in cell biology
2002 StandoutNature
jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun
1989
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
1998 Nature
Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
1993
Genetic Dissection of the Drosophila Cubitus interruptus Signaling Complex
2001
The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
1998
Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2
2003
The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation
1989
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Membrane traffic: a driving force in cytokinesis
2005
A Quantification of Pathway Components Supports a Novel Model of Hedgehog Signal Transduction
2009
Centriolin Anchoring of Exocyst and SNARE Complexes at the Midbody Is Required for Secretory-Vesicle-Mediated Abscission
2005
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
1999
UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans
2007
Post-translational modifications regulate microtubule function
2003
New players and puzzles in the Hedgehog signaling pathway
1998
Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression
1999
Gli regulation by the opposing activities of Fused and Suppressor of Fused
2000
A module of negative feedback regulators defines growth factor signaling
2007
Drosophila Exocyst Components Sec5, Sec6, and Sec15 Regulate DE-Cadherin Trafficking from Recycling Endosomes to the Plasma Membrane
2005
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
2001
Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage
1997 StandoutNobel
New light on Myc and Myb. Part II. Myb.
1990
Transducing Hedgehog: the story so far
1998
Negative regulation of serum-responsive enhancer elements
1989 Nature
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
2003
Myosin V Transports Secretory Vesicles via a Rab GTPase Cascade and Interaction with the Exocyst Complex
2011 StandoutNobel
Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus
2011
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment
2004
Mouse Suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1
1999
A Highly Conserved Amino-terminal Region of Sonic Hedgehog Is Required for the Formation of Its Freely Diffusible Multimeric Form
2005
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
1998
Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport
2000
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
1988
Mechanisms and functions of Hedgehog signalling across the metazoa
2011
Costal2 Functions as a Kinesin-like Protein in the Hedgehog Signal Transduction Pathway
2008
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
1998 StandoutNobel
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor
2006
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
2002 Nature
A Gain-of-Function Mutant of patched Dissects Different Responses to the Hedgehog Gradient
2000
Divergence of Hedgehog Signal Transduction Mechanism between Drosophila and Mammals
2006
Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway
1998
Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain
1988 Nature
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
2009
Wnt signalling in stem cells and cancer
2005 StandoutNature
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
1999
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
The patched gene in development and cancer
1998
Apical constriction: A cell shape change that can drive morphogenesis
2009
Microtubule motors at the intersection of trafficking and transport
2006
The primary cilium: a signalling centre during vertebrate development
2010 Standout
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
2005
Hedgehog-Regulated Costal2-Kinase Complexes Control Phosphorylation and Proteolytic Processing of Cubitus Interruptus
2005
Prostaglandin endoperoxide synthase: regulation of enzyme expression
1991
The role of kinases in the Hedgehog signalling pathway
2008
Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1
1995
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Effects of Ionizing Radiation and β-Adrenergic Stimulation on the Expression of Early Response Genes in Rat Parotid Glands
1992
Structure and polymorphism of the mouse prion protein gene.
1994 StandoutNobel
Gli1can rescue the in vivo function ofGli2
2001
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
2005
Animal Cell Cytokinesis
2001
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
2004
Gli proteins and the control of spinal‐cord patterning
2003
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
2000 Standout
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
jun-D: a third member of the jun gene family.
1989 Nobel
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila
2000
The Drosophila Protein Asp Is Involved in Microtubule Organization during Spindle Formation and Cytokinesis
2001
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c- fos gene
1998
Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands
1997 StandoutNobel
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
2000
STATs and Gene Regulation
1997 StandoutScience
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
2010
Evidence That the Leucine Zipper Is a Coiled Coil
1989 Science
Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism
2004
A FOS protein is present in a complex that binds a negative regulator of MYC.
1989 StandoutNobel
Predicting Coiled Coils from Protein Sequences
1991 StandoutScience
Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor
1996
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
Gli Proteins in Development and Disease
2011
Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
2000
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
1998
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2
2006 StandoutNobel
Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation
2000
Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene.
1991
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
The Hedgehog Response Network: Sensors, Switches, and Routers
2004 Science
Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes.
1988
The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
1999
Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction
2008
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
2006 StandoutNobel
Smoothened translates Hedgehog levels into distinct responses
2003
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
2005
Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog
1998
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
1998
Differential requirements of the Fused kinase for Hedgehog signalling in the Drosophila embryo
1999
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
2009
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
1990
Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus
2005
Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link
1990
cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.
1991
Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly
1998
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
2011
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
1998 StandoutNobel
Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling
2000
Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP
1989 StandoutScienceNobel
Toward a molecular definition of long-term memory storage
1996 StandoutNobel
Conserved microtubule–actin interactions in cell movement and morphogenesis
2003
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Sonic hedgehog Promotes G1Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
2000
Planarian Hh Signaling Regulates Regeneration Polarity and Links Hh Pathway Evolution to Cilia
2009 Science
Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins.
1989
Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes
2008 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A
1999
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
2006
Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
2007
Immediate early gene and HSP70 expression in hyperosmotic stress in MDCK cells
1991
Fos C-terminal mutations block down-regulation of c-fos transcription following serum stimulation.
1988
Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis
2002
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
1999
Wild-type p53 can down-modulate the activity of various promoters.
1991
Works of John C. Sisson being referenced
Reassessing the Role and Dynamics of Nonmuscle Myosin II during Furrow Formation in Early Drosophila Embryos
2003
Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
2005
Fragile X Protein Functions with Lgl and the PAR Complex in Flies and Mice
2005
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
1997 Nobel
The golgin Lava lamp mediates dynein-based Golgi movements during Drosophila cellularization
2005
Transcriptional autoregulation of the proto-oncogene fos
1988 Nature
Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos
1999
Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway
1997
Lava Lamp, a Novel Peripheral Golgi Protein, Is Required for Drosophila melanogaster Cellularization
2000