Standout Papers
Citation Impact
Citing Papers
Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA
2004 StandoutNobel
Developmentally regulated initiation of DNA synthesis by telomerase: evidence for factor-assisted de novo telomere formation
1997
Hallmarks of Cancer: The Next Generation
2011 Standout
Structural Elements in RNA
1991
Three telomerases with completely non-telomeric template replacements are catalytically active
2000
A telomerase component is defective in the human disease dyskeratosis congenita
1999 Nature
Circular rDNA Replicons Persist in Tetrahymena thermophila Transformants Synthesizing GGGGTC Telomeric Repeats
1995 StandoutNobel
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
1990
Rheumatoid arthritis
2016 Standout
Telomeres: No end in sight
1994 StandoutNobel
Gel Shift and UV Cross-linking Analysis of Tetrahymena Telomerase
1995 StandoutNobel
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
1997 Standout
Processive Utilization of the Human Telomerase Template
2004 StandoutNobel
A conserved secondary structure for telomerase RNA
1991 StandoutNobel
Method for Determining RNA 3' Ends and Application to Human Telomerase RNA
1996
An in vitro assay for saccharomyces telomerase requires EST1
1995
An alternative pathway for yeast telomere maintenance rescues est1− senescence
1993 StandoutNobel
Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
2003
Telomere positional effects and the regulation of cellular senescence
1992
The end of the (DNA) line.
2000 StandoutNobel
Telomere end-replication problem and cell aging
1992 StandoutNobel
Telomere states and cell fates
2000 StandoutNatureNobel
Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
1995 StandoutNobel
Tetrahymena Telomerase RNA levels increase during macronuclear development
1992 StandoutNobel
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
Functional Characterization and Developmental Regulation of Mouse Telomerase RNA
1995 StandoutScienceNobel
Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein
1990 Nobel
Extensive telomere repeat arrays in mouse are hypervariable
1990
TRF2 Protects Human Telomeres from End-to-End Fusions
1998
Structural and functional aspects of RNA pseudoknots
1992
A novel pseudoknot element is essential for the action of a yeast telomerase
2003 StandoutNobel
Human telomerase contains two cooperating telomerase RNA molecules
2001
Telomeres
1991 StandoutNobel
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
2006 StandoutNobel
Beginning to Understand the End of the Chromosome
2004 Nobel
Telomeres, telomerase and senescence
1990 StandoutNobel
The mouse telomerase RNA 5'-end lies just upstream of the telomerase template sequence
1998 StandoutNobel
Runaway telomere elongation caused by telomerase RNA gene mutations
1995 StandoutNatureNobel
Secondary Structure of Vertebrate Telomerase RNA
2000 StandoutNobel
Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates
1998
Mice without telomerase: what can they teach us about human cancer?
2000
Structure and polymorphism of human telomere-associated DNA
1990
Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
2001
The Tetrahymena p80/p95 Complex Is Required for Proper Telomere Length Maintenance and Micronuclear Genome Stability
2000
Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase
1991 Nature
Transposons in place of telomeric repeats at a Drosophila telomere
1993
The biogenesis and regulation of telomerase holoenzymes
2006
Conserved N-terminal Motifs of Telomerase Reverse Transcriptase Required for Ribonucleoprotein Assembly in Vivo
2003
Telomere loss: mitotic clock or genetic time bomb?
1991
Roles for RNA in Telomerase Nucleotide and Repeat Addition Processivity
2003
Telomerase primer specificity and chromosome healing
1991 Nature
The effects of nucleoside analogs on telomerase and telomeres inTetrahymena
1994 StandoutNobel
Telomere processing inEuplotes
1993
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
An altered repertoire of (AP-1) at the onset of replicative senescence
1992
TRF1 is a dimer and bends telomeric DNA
1997
Genetics and Molecular Biology of Telomeres
1992
Ciliate telomerase RNA structural features
1995
Developmentally programmed healing of chromosomes by telomerase in tetrahymena
1991 StandoutNobel
Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting
2000
Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro
1998
Hoogsteen G-G base pairing is dispensable for telomere healing in yeast
1992
Two types of telomeric chromatin in Tetrahymena thermophila 1 1Edited by T. Richmond
1998
A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n
1990 Nature
The telomerase reverse transcriptase: components and regulation
1998
Telomerase RNA function in recombinant Tetrahymena telomerase
1999
Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase
1996
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.
1996 StandoutNobel
TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase
1994 Science
Telomerase core components protect Candida telomeres from aberrant overhang accumulation
2007 StandoutNobel
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
1992 StandoutNobel
Telomerase activity in germline and embryonic cells of Xenopus.
1994 StandoutNobel
Telomerase is processive.
1991 StandoutNobel
A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts.
1994 StandoutNobel
TELOMERES AND THEIR CONTROL
2000 StandoutNobel
Telomerase and cancer: revisiting the telomere hypothesis
1996 StandoutNobel
Telomerase Is Processive
1991 StandoutNobel
Sequence-specific DNA primer effects on telomerase polymerization activity.
1993 StandoutNobel
Identification of Kluyveromyces lactis Telomerase: Discontinuous Synthesis along the 30-Nucleotide-Long Templating Domain
1998 StandoutNobel
Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang.
1996 Nobel
Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
1994
Ku is associated with the telomere in mammals
1999 StandoutNobel
Unusually Large Telomeric Repeats in the Yeast Candida albicans
1993
Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance
1996 Science
Identification of a nonprocessive telomerase activity from mouse cells.
1993 StandoutNobel
Lack of telomere shortening during senescence inParamecium.
1994 StandoutNobel
A Mammalian Telomerase-Associated Protein
1997 Science
Altering specific telomerase RNA template residues affects active site function.
1995 StandoutNobel
Architecture of telomerase RNA.
1994 StandoutNobel
Ciliate Telomerase Biochemistry
1999
Pseudo-templated transcription in prokaryotic and eukaryotic organisms.
1991
Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.
1996 StandoutNobel
Plasmodium falciparum Telomerase: De Novo Telomere Addition to Telomeric and Nontelomeric Sequences and Role in Chromosome Healing
1998
Processing of Nontelomeric 3′ Ends by Telomerase: Default Template Alignment and Endonucleolytic Cleavage
1996
Telomere fusions caused by mutating the terminal region of telomeric DNA
2000 StandoutNobel
Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.
1996 StandoutNobel
Drosophila telomeres: two transposable elements with important roles in chromosomes
1999
Telomerase in Yeast
1995 StandoutScienceNobel
Oligonucleotides complementary to the Oxytricha nova telomerase RNA delineate the template domain and uncover a novel mode of primer utilization.
1994
Telomeres and Their Synthesis
1990 StandoutScienceNobel
Reprogramming of Telomerase by Expression of Mutant Telomerase RNA Template in Human Cells Leads to Altered Telomeres That Correlate with Reduced Cell Viability
1997
Telomeres and telomerase
2004 StandoutNobel
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
1994 StandoutScience
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
1999
Dynamics of Telomeric DNA Turnover in Yeast
2002 StandoutNobel
Functional reconstitution of wild-type and mutant Tetrahymena telomerase.
1994 StandoutNobel
Telomerase in kinetoplastid parasitic protozoa
1999 StandoutNobel
Activation of telomerase in a human tumor.
1994
A Single Telomerase RNA Is Sufficient for the Synthesis of Variable Telomeric DNA Repeats in Ciliates of the Genus Paramecium
1996
An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila.
1995 StandoutNobel
Developmental and tissue-specific regulation of mouse telomerase and telomere length.
1995 StandoutNobel
Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA.
1995 Nobel
The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex
1998
Telomere dynamics in an immortal human cell line.
1994
Unusually large telomeric repeats in the yeast Candida albicans.
1993
Structural organization of the genes encoding the small nuclear RNAs U1 to U6 of Tetrahymena thermophila is very similar to that of plant small nuclear RNA genes
1992
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
1997 StandoutNobel
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
2001 StandoutNobel
Oligonucleotides Complementary to the Oxytricha nova Telomerase RNA Delineate the Template Domain and Uncover a Novel Mode of Primer Utilization
1994
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.
1996 StandoutNobel
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Drosophila telomeres: two transposable elements with important roles in chromosomes
2000
Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines
1996 StandoutNobel
Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.
1994 Nobel
Expression of mouse telomerase catalytic subunit in embryos and adult tissues
1998
Restoration of Telomeres in Human Papillomavirus-Immortalized Human Anogenital Epithelial Cells
1994
Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using an in VivoReconstitution System
2001
Specific RNA Residue Interactions Required for Enzymatic Functions of Tetrahymena Telomerase
1996 StandoutNobel
Telomeres: Beginning to Understand the End
1995 Science
Sequence-Specific DNA Primer Effects on Telomerase Polymerization Activity
1993 StandoutNobel
Protection of Telomeres by the Ku Protein in Fission Yeast
2000 Nobel
Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation.
1993 StandoutNobel
Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.
1994
Telomerase and DNA End Replication: No Longer a Lagging Strand Problem?
1995 ScienceNobel
The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein
1999 StandoutNobel
Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation
1997 StandoutScienceNobel
Structure and function of telomeres
1991 StandoutNatureNobel
Telomeres
1991
Est1 has the properties of a single-stranded telomere end-binding protein.
1996
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains
1997 StandoutNobel
Boundary elements of the Tetrahymena telomerase RNA template and alignment domains.
1995 StandoutNobel
Uncapping and Deregulation of Telomeres Lead to Detrimental Cellular Consequences in Yeast
1999 StandoutNobel
Flexible Positioning of the Telomerase-Associated Nuclease Leads to Preferential Elimination of Nontelomeric DNA
1998
Works of John Bradley being referenced
Tofacitinib versus Methotrexate in Rheumatoid Arthritis
2014
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
1990 StandoutNatureNobel
Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis
2012