Standout Papers
Citation Impact
Citing Papers
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension
2010
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
A Universal Chemical Enrichment Method for Mapping the Yeast N-glycoproteome by Mass Spectrometry (MS)
2014
Structure and Biosynthesis of the Mannan Component of the Yeast Cell Envelope
1976
Lectin‐like oxidized low density lipoprotein receptor‐1 (LOX‐1) serves as an endothelial receptor for advanced glycation end products (AGE)
2002
Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes
2011
Glucose‐enriched medium enhances cell‐mediated low density lipoprotein peroxidation
1995
Obesity and Systemic Oxidative Stress
2003
Metabolism of 8‐iso‐prostaglandin F2α
1998
Genome-wide Analysis of Histone Lysine Methylation Variations Caused by Diabetic Conditions in Human Monocytes
2007
RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy
2003
AGEs and Diabetic Retinopathy
2010
Increased atherosclerosis in streptozotocin-induced diabetic mice.
1996
Accumulation of N<sup>σ</sup>-(Carboxy-methyl)lysine and Changes inGlomerular Extracellular MatrixComponents in Otsuka Long-EvansTokushima Fatty Rat:A Model of Spontaneous NIDDM
1998
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions
2004
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Modification of Proteins In Vitro by Physiological Levels of Glucose
2003
An agent cleaving glucose-derived protein crosslinks in vitro and in vivo
1996 Nature
Quantitative site-specific analysis of protein glycosylation by LC-MS using different glycopeptide-enrichment strategies
2009
Spironolactone exhibits direct renoprotective effects and inhibits renal renin–angiotensin–aldosterone system in diabetic rats
2008
Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice
2009
Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
2007
A systematic look at an old problem
2008 Nature
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy
2005
Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats
1997
Advanced glycation and endothelial functions: A link towards vascular complications in diabetes
2004
Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells
2003
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
2007
Protein carbonylation, cellular dysfunction, and disease progression
2006
Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores
1996
N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression
1999
Accelerated evolution of the electron transport chain in anthropoid primates
2004
Electron transfer dissociation mass spectrometry in proteomics
2012
Protein glycation and oxidative stress in diabetes mellitus and ageing
1991
Bidirectional Transport by Distinct Populations of COPI-Coated Vesicles
1997 StandoutNobel
Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products
2002
Effect of green tea extract on advanced glycation and cross-linking of tail tendon collagen in streptozotocin induced diabetic rats
2007
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.
1998
In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques
2000
Tumour necrosis factor‐alpha plasma level in patients with type 1 diabetes mellitus and its association with glycaemic control and cardiovascular risk factors
2000
Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis
2008
Caloric restriction and aging: an update
2000
Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.
1996
Global heterochromatin loss
2012
Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes
2011
Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls
2006
Radical AGEing in Alzheimer's disease
1995
Free‐Radical Theory of Aging
1994
Diabetic dyslipidaemia: from basic research to clinical practice*
2003
Protein Oxidation in Aging, Disease, and Oxidative Stress
1997 Standout
Glutathione metabolism and oxidative stress in neonatal rat tissues from streptozotocin‐induced diabetic mothers
2004
Glutathione-dependent detoxification of α-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors
1998
Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology
2011
Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments
1991 StandoutNobel
Calorie Restriction Improves Cardiovascular Risk Factors via Reduction of Mitochondrial Reactive Oxygen Species in Type II Diabetic Rats
2006
The effect of advanced glycation end-product formation upon cell-matrix interactions
1999
Characterization and Functional Analysis of the Promoter of RAGE, the Receptor for Advanced Glycation End Products
1997
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans
2009
DNA Repair, Genome Stability, and Aging
2005
Insulin Signaling Is Inhibited by Micromolar Concentrations of H2O2
1999
Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis
2001
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempol
2007
Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.
1995
The role of oxidative stress in neuropathy and other diabetic complications
1995
Mitochondria, Oxidants, and Aging
2005 Standout
Free Radical Involvement in Aging
1993
Putative roles of kinin receptors in the therapeutic effects of angiotensin 1-converting enzyme inhibitors in diabetes mellitus
2004
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
2013
Analysis of Diffrentiation and Transformation of Cells by Lectins
1988
High Glucose Inhibits Glucose-6-phosphate Dehydrogenase via cAMP in Aortic Endothelial Cells
2000
Glycation induces expansion of the molecular packing of collagen
1988
Role of fructose in glycation and cross-linking of proteins
1988
A New Perspective on Therapeutic Inhibition of Advanced Glycation in Diabetic Microvascular Complications: Common Downstream Endpoints Achieved Through Disparate Therapeutic Approaches?
2009
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
2006
Taking a “good” look at free radicals in the aging process
2011
[25] Role of oxidized amino acids in protein breakdown and stability
1995
RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes
2009
Novel RNA catalysts for the Michael reaction
2001
The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
1995
Nitric oxide inhibits the formation of advanced glycation end products
2000
Superoxide production from nonenzymatically glycated protein
1988
Scavenger receptors for oxidized and glycated proteins
2003
F2-isoprostanes mediate high glucose-induced TGF-β synthesis and glomerular proteinuria in experimental type I diabetes
2000
Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress
1997
RAGE: A New Target for the Prevention and Treatment of the Vascular and Inflammatory Complications of Diabetes
2000
Free radical theory of aging
1992
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells
2003
Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility
1997
Analytical glycobiology at high sensitivity: current approaches and directions
2012
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Advanced glycosylation end products in skin, serum, saliva and urine and its association with complications of patients with Type 2 diabetes mellitus
2005
Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats
1993
RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease
2002
Angiotensin II Receptor Antagonists and Angiotensin-Converting Enzyme Inhibitors Lower In Vitro the Formation of Advanced Glycation End Products
2002
Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes
2004
Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus.
1992
Advanced Glycation Urinary Protein-Bound Biomarkers and Severity of Diabetic Nephropathy in Man
2011
Inhibitors of Advanced Glycation End Product Formation and Neurovascular Dysfunction in Experimental Diabetes
2005
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Oxidative derangement in rat synaptosomes induced by hyperglycaemia: restorative effect of dehydroepiandrosterone treatment
2000
Advanced glycoxidation end products in commonly consumed foods
2004
Applications of reversible covalent chemistry in analytical sample preparation
2012
Modulation of Soluble Receptor for Advanced Glycation End Products by Angiotensin-Converting Enzyme-1 Inhibition in Diabetic Nephropathy
2005
Molecular aspects of lipoic acid in the prevention of diabetes complications
2001
Atherogenesis and Advanced Glycation: Promotion, Progression, and Preventiona
1997
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
2010
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
The Hallmarks of Aging
2013 Standout
Renal catabolism of advanced glycation end products: The fate of pentosidine
1998
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Immunohistochemical Evidence for an Increased Oxidative Stress and Carbonyl Modification of Proteins in Diabetic Glomerular Lesions
1999
Advanced glycation end products induce apoptosis and procoagulant activity in cultured human umbilical vein endothelial cells
1999
Cell surface glycoprotein profiling of cancer cells based on bioorthogonal chemistry
2012
Localization of the binding site for the human high-affinity Fc receptor on IgG
1988 StandoutNatureNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The binding site for C1q on IgG
1988 StandoutNatureNobel
Advanced glycation end-products: a review
2001 Standout
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
Activation of Nuclear Factor-κB in Cultured Endothelial Cells by Increased Glucose Concentration: Prevention by Calphostin C
1997
Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.
1994
Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products.
1993
Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
2010
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
1988 Standout
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice
2005
Involvement of Hydrogen Peroxide in Collagen Cross-linking by High Glucose in Vitro and in Vivo
1996
A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans
2007
Extending life span by increasing oxidative stress
2011
Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen
2009
Molecular mechanisms of ageing in connective tissues
2001
Mitochondria as Oxidative Signaling Organelles in T-cell Activation: Physiological Role and Pathological Implications
2013
Liquid chromatography-based determination of urinary free and total N(epsilon)-(carboxymethyl)lysine excretion in normal and diabetic subjects
2003
The role of nuclear architecture in genomic instability and ageing
2007
Activation of Oxidative Stress by Acute Glucose Fluctuations Compared With Sustained Chronic Hyperglycemia in Patients With Type 2 Diabetes
2006 Standout
Can antioxidant vitamins materially reduce oxidative damage in humans?
1999
CD36 Is Not Involved in Scavenger Receptor–Mediated Endocytic Uptake of Glycolaldehyde- and Methylglyoxal-Modified Proteins by Liver Endothelial Cells
2005
Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats
2010
Lipid Peroxidation in Diabetes Mellitus
2004
The Free Radical Theory of Aging
2003
Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling
2010
Glycation of Skin Collagen in Type I Diabetes Mellitus: Correlation With Long-Term Complications
1986
Evidence for glucose-mediated covalent cross-linking of collagen after glycosylation in vitro
1985
Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy
2011
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
2015 StandoutNobel
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
2005 Standout
Nox4 NAD(P)H Oxidase Mediates Hypertrophy and Fibronectin Expression in the Diabetic Kidney
2005
Factors affecting the efficiency of co-translational processing of a de novo synthesized glycosylated immunoglobulin light chain.
1980
Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
2008
De novo synthesis and glycosylation of the MOPC-46B mouse immunoglobulin light chain in cell-free extracts.
1977
PRODUCTION OF PSEUDODIABETIC RENAL GLOMERULAR CHANGES IN MICE AFTER REPEATED INJECTIONS OF GLUCOSYLATED PROTEINS
1980
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
The Free Radical Theory of Aging Matures
1998 Standout
Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins.
1994
Glycosylation of glomerular basement membrane in type 1 (insulin-dependent) diabetic children
1982
Advanced Glycation End Products
2006 Standout
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Hypothesis
1985
Studies on the attachment of carbohydrate to ovalbumin nascent chains in hen oviduct.
1976
Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.
1994
Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin
2002
Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway.
1987 StandoutNobel
Molecular Coproscopy: Dung and Diet of the Extinct Ground Sloth Nothrotheriops shastensis
1998 StandoutScienceNobel
Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.
1993
Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis
2001
Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis
2004
Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling
1980
Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F
1985
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
1994
Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications
1984
Glycation, Inflammation, and RAGE
2003
Intracellular protein topogenesis
1980 StandoutNobel
The breakdown of pre‐existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
2003
Heterotypic tetramer (A2D2) complexes of non-epidermal keratins isolated from cytoskeletons of rat hepatocytes and hepatoma cells
1984
The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes
2009
Signal transduction by reactive oxygen species
2011 Standout
The participation of lipid-linked oligosaccharide in synthesis of membrane glycoproteins.
1975
Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes
2008
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
1992
Recognition and receptor-mediated uptake of a lysosomal enzyme, α-l-iduronidase, by cultured human fibroblasts
1977
Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE
2002
Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis.
1997
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors
1983 StandoutNobel
Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole
1982 StandoutNobel
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions
2004
Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy.
1985 Standout
From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth Factors/Cytokines
2004
Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.
1994
Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway
2004
Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice
2007
Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
2012
The insulin cell: Its cellular environment and how it processes (Pro)insulin
1986
Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein
1978 StandoutNobel
Inflammation and Atherosclerosis
2002 Standout
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
2006
Biological significance of carbohydrate chains on monoclonal antibodies.
1983
Reduction of the Accumulation of Advanced Glycation End Products by ACE Inhibition in Experimental Diabetic Nephropathy
2002
Primary structural requirements for the enzymatic formation of the N-glycosidic bond in glycoproteins. Studies with natural and synthetic peptides.
1979
Insulin resistance is a cellular antioxidant defense mechanism
2009
Kidney Hypoxia, Attributable to Increased Oxygen Consumption, Induces Nephropathy Independently of Hyperglycemia and Oxidative Stress
2013
Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.
1996
Oxidative Stress as a Regulator of Gene Expression in the Vasculature
1999
Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway
2007
Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.
2000
Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats
2003
Effector functions of a monoclonal aglycosylated mouse IgG2a: Binding and activation of complement component C1 and interaction with human monocyte Fc receptor
1985
Activation of Receptor for Advanced Glycation End Products
1999
Enzymatic conversion of proteins to glycoproteins.
1977
Age-associated, oxidatively modified proteins: A critical evaluation
1997
ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING
1995
The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein
1978
Inhibition of the Apparent Rate of Synthesis of the Vacuolar Glycoprotein Carboxypeptidase Y and Its Protein Antigen by Tunicamycin in Saccharomyces cerevisiae
1976
Mechanisms of Diabetic Complications
2013 Standout
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
1981 StandoutNobel
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
1999
The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide
1994
A lipid-linked oligosaccharide intermediate in glycoprotein synthesis. Characterization of [Man-14C]glycoproteins labeled from [Man-14C]oligosaccharide-lipid and GDP-[14C]Man.
1975
Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts.
1977
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking
1986 Science
Glycated and Oxidized Protein Degradation Products Are Indicators of Fasting and Postprandial Hyperglycemia in Diabetes
2005
The product of the avian erythroblastosis virus erbB locus is a glycoprotein
1983 StandoutNobel
Recent insights into diabetic renal injury from thedb/dbmouse model of type 2 diabetic nephropathy
2010
Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications.
1994
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy
2002
Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products
2003
In vitro synthesis, glycosylation, and membrane insertion of the four subunits of Torpedo acetylcholine receptor.
1981 StandoutNobel
Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat
2004
Mitochondrial DNA mutations in disease and aging
2011
Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes
1975
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy
2009
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Identification of Galectin-3 As a High-Affinity Binding Protein for Advanced Glycation End Products (AGE): A New Member of the AGE-Receptor Complex
1995
Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen.
1992
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Elevated Mitochondrial Cytochrome P450 2E1 and Glutathione S-Transferase A4-4 in Streptozotocin-Induced Diabetic Rats
2004
High Levels of Dietary Advanced Glycation End Products Transform Low-Dersity Lipoprotein Into a Potent Redox-Sensitive Mitogen-Activated Protein Kinase Stimulant in Diabetic Patients
2004
Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the Risk of Future 10-Year Progression of Diabetic Retinopathy and Nephropathy in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications Participants With Type 1 Diabetes
2005
Glycobioinformatics: Current strategies and tools for data mining in MS ‐based glycoproteomics
2012
Advanced Glycation End Products Are Direct Modulators of β-Cell Function
2011
Nonenzymatic Browning in Vivo: Possible Process for Aging of Long-Lived Proteins
1981 Science
Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor κB in PBMCs
2003
L-arginine reduces heart collagen accumulation in the diabetic db/db mouse.
1994
pH and the recycling of transferrin during receptor-mediated endocytosis.
1983 StandoutNobel
Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy
1997
Chemical Glycoproteomics
2016 StandoutNobel
Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast
1981 StandoutNobel
The period clock locus of D. melanogaster codes for a proteoglycan
1986 StandoutNobel
A molecular analysis of dietary diversity for three archaic Native Americans
2001 StandoutNobel
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
2001
Works of John Baynes being referenced
Carboxymethylethanolamine, a Biomarker of Phospholipid Modification during the Maillard Reaction in Vivo
1997
Pyridoxamine Traps Intermediates in Lipid Peroxidation Reactions in Vivo
2003
AGE-breakers cleave model compounds, but do not break Maillard crosslinks in skin and tail collagen from diabetic rats
2003
Age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine and N.epsilon.-(carboxymethyl)hydroxylysine in human skin collagen
1991
Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications
2003
Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia?
1998
Chemical Modification of Proteins by Lipids in Diabetes
2003
Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose
1995
Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia
1998
Accumulation of Maillard reaction products in skin collagen in diabetes and aging.
1993
Proteomic Analysis of Arginine Adducts on Glyoxal-modified Ribonuclease
2004
Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus.
1991
Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes
2009
Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products
2000
Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus.
1993
The Role of AGEs and AGE Inhibitors in Diabetic Cardiovascular Disease
2005
Reaction of ascorbate with lysine and protein under autoxidizing conditions: formation of N.epsilon.-(carboxymethyl)lysine by reaction between lysine and products of autoxidation of ascorbate
1990
Formation of Reactive Intermediates from Amadori Compounds under Physiological Conditions
1995
Role of the Maillard Reaction in Diabetes Mellitus and Diseases of Aging
1996
Caloric Restriction Decreases Age-Dependent Accumulation of the Glycoxidation Products, Nisin-(Carboxymethyl)lysine and Pentosidine, in Rat Skin Collagen
1995
Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat
2002
A Post-Amadori Inhibitor Pyridoxamine Also Inhibits Chemical Modification of Proteins by Scavenging Carbonyl Intermediates of Carbohydrate and Lipid Degradation
2002
The role of AGEs in aging: causation or correlation
2001
Succination of Proteins by Fumarate
2008
Oxidation of glycated proteins: age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine in lens proteins
1989
Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications
1999
Chelating Activity of Advanced Glycation End-product Inhibitors
2001
Maillard reaction products in tissue proteins: New products and new perspectives
2003
The Maillard reaction in vivo
1991
The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions
1996
Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity
2009
Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition
2005
Glycoxidation and lipoxidation in atherogenesis
2000
Amadorins: Novel Post-Amadori Inhibitors of Advanced Glycation Reactions
1999
Nonenzymatic Glycosylation of Protein Does Not Increase With Age in Normal Human Lenses
1990
Role of the Maillard Reaction in Aging of Tissue Proteins
1998
Metabolism of Fructose-3-phosphate in the Diabetic Rat Lens
1995
Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes.
1997
Pathways of Formation of Glycoxidation Products during Glycation of Collagen
1995
Pyridoxamine, an Inhibitor of Advanced Glycation Reactions, Also Inhibits Advanced Lipoxidation Reactions
2000
Immunohistochemical and ELISA Assays for Biomarkers of Oxidative Stress in Aging and Diseasea
1998
The Maillard Hypothesis on Aging: Time to Focus on DNA
2002
The serum concentration of the advanced glycation end-product N -(carboxymethyl)lysine is increased in uremia: Technical Note
1997
S-(2-Succinyl)cysteine: A novel chemical modification of tissue proteins by a Krebs cycle intermediate
2006
Measurement of Pentosidine in Biological Samples
2003
Detection of 3-deoxyfructose and 3-deoxyglucosone in human urine and plasma: Evidence for intermediate stages of the maillard reaction in vivo
1992
Chemical modification of muscle protein in diabetes
2004
The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats
2003
Stimulation of cholesteryl ester synthesis in human monocyte-derived macrophages by low-density lipoproteins from Type 1 (insulin-dependent) diabetic patients: the influence of non-enzymatic glycosylation of low-density lipoproteins
1987
N.epsilon.-(Carboxymethyl)lysine Is a Dominant Advanced Glycation End Product (AGE) Antigen in Tissue Proteins
1995
Role of dyslipidemia and AGE/ALE formation in the progression of nephropathy and retinopathy in STZ-diabetic rats
2002
13C NMR investigation of nonenzymatic glucosylation of protein. Model studies using RNase A.
1983
Effect of phosphate on the kinetics and specificity of glycation of protein.
1987
Effect of glycosylation on the in vivo circulating half-life of ribonuclease.
1976
Characterization of an Imidazolium Salt Formed from Glyoxal and N.alpha.-Hippuryllysine: A Model for Maillard Reaction Crosslinks in Proteins
1995
A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease
2008
The effect of α-mannose-terminal oligosaccharides on the survival of glycoproteins in the circulation
1978
3-Deoxyfructose concentrations are increased in human plasma and urine in diabetes
1994
Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus.
1979
Effect of diabetes and aging on carboxymethyllysine levels in human urine
1991
Chemistry of the fructosamine assay: D-glucosone is the product of oxidation of Amadori compounds
1994
N ε-(Carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins
1997
The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes
2002
Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction
1994
Enrichment and Analysis of Nonenzymatically Glycated Peptides: Boronate Affinity Chromatography Coupled with Electron-Transfer Dissociation Mass Spectrometry
2007
Quantification of malondialdehyde and 4-hydroxynonenal adducts to lysine residues in native and oxidized human low-density lipoprotein
1997
The Role of a Dolichol-Oligosaccharide as an Intermediate in Glycoprotein Biosynthesis
1974
Nonenzymatically glucosylated albumin. In vitro preparation and isolation from normal human serum.
1979
Nonenzymatic glucosylation and glucose-dependent cross-linking of protein.
1983
Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.
1986
Oxidative degradation of glucose adducts to protein. Formation of 3-(N epsilon-lysino)-lactic acid from model compounds and glycated proteins.
1988
Precursor keratin protein from human epidermis
1978
Effect of Diabetes and Aging on Carboxymethyllysine Levels in Human Urine
1991
Glycation, Glycoxidation, and Cross-Linking of Collagen by Glucose: Kinetics, Mechanisms, and Inhibition of Late Stages of the Maillard Reaction
1994
Carbohydrate-mediated clearance of antibody . antigen complexes from the circulation. The role of high mannose oligosaccharides in the hepatic uptake of IgM . antigen complexes.
1980
Characterization of an imidazolium compound formed by reaction of methylglyoxal and Nα-hippuryllysine
1995
Nonenzymatic Glucosylation of Serum Proteins in Diabetes Mellitus
1979
The Amadori product on protein: structure and reactions.
1989
Role of Glycation in Modification of Lens Crystallins in Diabetic and Nondiabetic Senile Cataracts
1991
3-Deoxyfructose Concentrations are Increased in Human Plasma and Urine in Diabetes
1994
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
1999 Standout
Age-related accumulation of Maillard reaction products in human articular cartilage collagen
2000
Improved Methods for the Enrichment and Analysis of Glycated Peptides
2008
Role of lipids in chemical modification of proteins and development of complications in diabetes
2003
Carbohydrate-mediated clearance of immune complexes from the circulation. A role for galactose residues in the hepatic uptake of IgG-antigen complexes.
1980
Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation
1993
Non-enzymatic glycosylation and the chronic complications of diabetes: an overview
1984
Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo
1991
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
2003
Glycation of amino groups in protein. Studies on the specificity of modification of RNase by glucose.
1985
Nonenzymatic glucosylation of rat albumin. Studies in vitro and in vivo.
1979
Role of Oxygen in Cross-Linking and Chemical Modification of Collagen by Glucose
1992
Oxidized amino acids in lens protein with age. Measurement of o-tyrosine and dityrosine in the aging human lens
1993
Glycosylation of low density lipoprotein in patients with Type I (insulin-dependent) diabetes: Correlations with other parameters of glycaemic control
1986
Characterization of glycated proteins by 13C NMR spectroscopy. Identification of specific sites of protein modification by glucose.
1985
[8] Nonenzymatic glucosylation of lysine residues in albumin
1984
Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes
2007
The Role of Mannosyl-phosphoryl-dihydropolyisoprenol in the Synthesis of Mammalian Glycoproteins
1973
Role of Oxidative Stress in Development of Complications in Diabetes
1991 Standout