Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
2009
LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses
2010
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
2015
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
2011
Autophagosomes form at ER–mitochondria contact sites
2013 StandoutNature
The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
2010
Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
2013
Necroptosis and its role in inflammation
2015 StandoutNature
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
2016 Standout
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
RIG-I-like receptors: their regulation and roles in RNA sensing
2020
TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING
2015
Structural mechanism of cytosolic DNA sensing by cGAS
2013 Nature
Marine natural products
1990 Standout
Drug development from marine natural products
2008 Standout
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
2010 Standout
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
2016
TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination
2012
Marine natural products
2009
Pattern Recognition Receptors and Inflammation
2010 Standout
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses
2015
Autophagy: Renovation of Cells and Tissues
2011 Standout
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids
2016
The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
2014 StandoutNobel
Recognition of viruses by cytoplasmic sensors
2010
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
2014
Immune Signaling by RIG-I-like Receptors
2011
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Intracellular DNA recognition
2010
Cardiac glycosides are potent inhibitors of interferon-β gene expression
2010
Immune Sensing of DNA
2013
With or without you — Proteomics with or without major plasma/serum proteins
2016
Methods in Mammalian Autophagy Research
2010 Standout
Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease
2012
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
Autophagy and innate immunity: Triggering, targeting and tuning
2010
Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome
2011
A Bioorthogonal Reaction of N‐Oxide and Boron Reagents
2015 StandoutNobel
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
2013
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
2014
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
2009
Solid‐Phase Synthesis of Tetrahydro‐β‐carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N‐Carbamyliminium Pictet–Spengler Reactions
2006 StandoutNobel
Field-resolved infrared spectroscopy of biological systems
2020 StandoutNatureNobel
Cytoplasmic DNA innate immune pathways
2011
IFI16 is an innate immune sensor for intracellular DNA
2010
Intrinsic antiviral immunity
2012
Innate Immune Receptors
2016
Autophagy in immunity and inflammation
2011 StandoutNature
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
2009 StandoutNature
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
2014
STING is a direct innate immune sensor of cyclic di-GMP
2011 Nature
Inflammasomes in health and disease
2012 StandoutNature
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
2009 Nature
Biosynthesis and function of polyacetylenes and allied natural products
2008
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Biologically active quinoline and quinazoline alkaloids part I
2017
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
RIGorous Detection: Exposing Virus Through RNA Sensing
2010 Science
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Biologically active quinoline and quinazoline alkaloids part II
2018
Cytosolic DNA sensors regulating type I interferon induction
2011
Human Papillomavirus (HPV) Upregulates the Cellular Deubiquitinase UCHL1 to Suppress the Keratinocyte's Innate Immune Response
2013
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA
2009
Homologation of the Fischer Indolization: A Quinoline Synthesis via Homo‐Diaza‐Cope Rearrangement
2020 StandoutNobel
Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
2021 StandoutNobel
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
2012
Nucleic Acid Recognition by the Innate Immune System
2011
Shining Light on the Secreted Luciferases of Marine Copepods: Current Knowledge and Applications
2018
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport
2017
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
2013
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality
2014
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKϵ and DDX3
2010
Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506
2018
Regulation of Adaptive Immunity by the Innate Immune System
2010 StandoutScience
Melanoma Differentiation–Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling To Suppress Virus Replication
2013
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection
2015
Direct Organocatalytic Asymmetric Aldol Reactions of α-Amino Aldehydes: Expedient Syntheses of Highly Enantiomerically Enriched anti-β-Hydroxy-α-amino Acids
2004
Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery
2008
Asymmetric Enamine Catalysis
2007 StandoutNobel
Enantioselective Rhodium‐Catalyzed Atom‐Economical Macrolactonization
2016
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Confinement-Controlled, Either syn- or anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
2021 StandoutNobel
The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β during Chlamydia trachomatis Infection
2014
Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking
2012
N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2
2018 StandoutNobel
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
2013 Science
Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways
2017
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of John B. MacMillan being referenced
Tropolactones A–D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus
2006
RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
2009
Enantioselective Total Synthesis of (+)‐Milnamide A and Evidence of Its Autoxidation to (+)‐Milnamide D
2004
Precursor-directed generation of amidine containing ammosamide analogs: ammosamides E–P
2012
Ammosamides A and B Target Myosin
2008
An N-acyl homolog of mycothiol is produced in marine actinomycetes
2008
The Ammosamides: Structures of Cell Cycle Modulators from a Marine‐Derived Streptomyces Species
2008
AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival
2015
Herbacic Acid, a Simple Prototype of 5,5,5-Trichloroleucine Metabolites from the Sponge Dysidea herbacea
1999
Erythrolic acids A–E, Meroterpenoids from a Marine-DerivedErythrobactersp.
2012
Structure of (−)-Neodysidenin from Dysidea herbacea. Implications for Biosynthesis of 5,5,5-Trichloroleucine Peptides
2000
Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways
2016
Lodopyridone, a Structurally Unprecedented Alkaloid from a Marine Actinomycete
2009
Erythrazoles A–B, Cytotoxic Benzothiazoles from a Marine-DerivedErythrobactersp.
2011
Anthraquinones from a Marine-Derived Streptomyces spinoverrucosus
2012
Lobocyclamide B from Lyngbya confervoides. Configuration and Asymmetric Synthesis of β-Hydroxy-α-amino Acids by (−)-Sparteine-Mediated Aldol Addition
2002
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1
2013
Caminosides B−D, Antimicrobial Glycolipids Isolated from the Marine Sponge Caminus sphaeroconia
2006
Phorbasides A−E, Cytotoxic Chlorocyclopropane Macrolide Glycosides from the Marine Sponge Phorbas sp. CD Determination of C-Methyl Sugar Configurations
2008
A New Peptide Isolated from a Marine Derived Streptomyces bacillaris
2012
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
2014
Majusculoic Acid, a Brominated Cyclopropyl Fatty Acid from a Marine Cyanobacterial Mat Assemblage
2005
Ammosamide D, an Oxidatively Ring Opened Ammosamide Analog from a Marine-Derived Streptomyces variabilis
2012
Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor
2013
Chlorocyclopropane Macrolides from the Marine Sponge Phorbas sp. Assignment of the Configurations of Phorbasides A and B by Quantitative CD
2007
Caylobolide A, a Unique 36-Membered Macrolactone from a Bahamian Lyngbya majuscula
2002
Enantioselective Total Synthesis of (+)‐Milnamide A and Evidence of Its Autoxidation to (+)‐Milnamide D
2004