Standout Papers
Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans
2006 Science
Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila
2002 Science
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
2012 StandoutScienceNobel
The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
2003
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance
2001 Science
The two origins of hemocytes in Drosophila
2003
Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression
2005
Apoptotic Force and Tissue Dynamics During Drosophila Embryogenesis
2008 Science
Caspase-mediated processing of the Drosophila NF-κB factor Relish
2003
Hallmarks of Cancer: The Next Generation
2011 Standout
A Ubiquitin-Proteasome Pathway Represses the Drosophila Immune Deficiency Signaling Cascade
2002
The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling
1998
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
2002 Nature
The Drosophila inhibitor of apoptosis D‐IAP1 suppresses cell death induced by the caspase drICE
1998
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
2003
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster
2003
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
MicroRNAs
2004 Standout
The Drosophila immune system detects bacteria through specific peptidoglycan recognition
2003
The genetic regulation of apoptosis
1995
The roles of JAK/STAT signaling in Drosophila immune responses
2004
Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation
2002
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
2002 Nature
Evolution of TNF Signaling Mechanisms
2002
The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
2000
Three-Dimensional Structure of the Apoptosome
2002
Interactions between the cellular and humoral immune responses in Drosophila
2000
p53 — a Jack of all trades but master of none
2009
The role of the Drosophila TAK homologue dTAK during development
2001
Identification of caspases and apoptosis in the simple metazoan Hydra
1999
The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism
2003
Drosophila immunity: two paths to NF-κB
2001
p53: new roles in metabolism
2007
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice
2007 StandoutNobel
The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD
2002 StandoutNobel
Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen
2004
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
2000 Standout
Cell Death
2004 Standout
Drosophila Scavenger Receptor CI Is a Pattern Recognition Receptor for Bacteria
2001
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
2001 StandoutNobel
Tackling both sides of the host–pathogen equation with Caenorhabditis elegans
2002
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
1993 Standout
Role of Drosophila IKKγ in a Toll-independent antibacterial immune response
2000 StandoutNobel
Polyglutamine-Expanded Human Huntingtin Transgenes Induce Degeneration of Drosophila Photoreceptor Neurons
1998
Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
1998 Nature
The Toll and Imd pathways are the major regulators of the immune response in Drosophila
2002
In Vivo RNA Interference Analysis Reveals an Unexpected Role for GNBP1 in the Defense against Gram-positive Bacterial Infection in Drosophila Adults
2004
The biochemistry of apoptosis
2000 StandoutNature
BCL-2 family members and the mitochondria in apoptosis
1999 Standout
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses
2001
NF-κB signaling pathways in mammalian and insect innate immunity
2001
Innate recognition systems in insect immunity and development: new approaches in
2000
p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease
2005
The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers
2006
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Programmed cell death in invertebrates
1996
The antibacterial arm of the Drosophila innate immune response requires an IκB kinase
2001
Drosophila S2 cells: an alternative infection model for Listeria monocytogenes
2003
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions
2003
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
2002
The modular nature of apoptotic signaling proteins
1999
Cell Death in Development
1999
A Model of Bacterial Intestinal Infections in Drosophila melanogaster
2007 StandoutNobel
Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila
2004
A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity
2004 Nobel
Inducible Expression of Double-Stranded RNA Reveals a Role for dFADD in the Regulation of the Antibacterial Response in Drosophila Adults
2002
Croquemort, A Novel Drosophila Hemocyte/Macrophage Receptor that Recognizes Apoptotic Cells
1996
Drosophila innate immunity: an evolutionary perspective
2002 StandoutNobel
The immune response of Drosophila
2003 StandoutNatureNobel
p53 isoforms can regulate p53 transcriptional activity
2005
p53 in health and disease
2007 Standout
Taking dendritic cells into medicine
2007 StandoutNatureNobel
IAP proteins: blocking the road to death's door
2002
A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death
2001
Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression
2011 StandoutNobel
Toll receptors in innate immunity
2001 StandoutNobel
Genetics of programmed cell death in C. elegans: past, present and future
1998 StandoutNobel
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
2000 Standout
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
2000
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
2002
Apoptosis without caspases: an inefficient molecular guillotine?
1999
Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila
1998
Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis
2001 StandoutNobel
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
2003 Standout
Immune Activation of NF-κB and JNK Requires Drosophila TAK1
2003
Targeting of TAK1 by the NF-κB protein Relish regulates the JNK-mediated immune response in Drosophila
2004
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis
2006
Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis
1997 StandoutNobel
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
2002 StandoutNobel
Reassessing the role of p53 in cancer and ageing from an evolutionary perspective
2007
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
1996 Nature
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
2001 Nature
The evolution and genetics of innate immunity
2001 StandoutNobel
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
The road to Toll
2004
Programmed Cell Death in Animal Development
1997 Standout
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID
1999
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
Constitutive Phosphorylation Mutation in Fas-associated Death Domain (FADD) Results in Early Cell Cycle Defects
2007
Of flies and men; p53, a tumour suppressor
2004
Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity
2007
Inhibitor of apoptosis 2 and TAK1‐binding protein are components of the Drosophila Imd pathway
2005
The functions of animal microRNAs
2004 StandoutNatureNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Cooperative control of Drosophila immune responses by the JNK and NF‐κB signaling pathways
2006
How Drosophila combats microbial infection: a model to study innate immunity and host–pathogen interactions
2002
Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall
2010 Nature
Ras Promotes Cell Survival in Drosophila by Downregulating hid Expression
1998
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
2002
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
The autophagy effector Beclin 1: a novel BH3-only protein
2008
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
The Role of Ubiquitination in Drosophila Innate Immunity
2005
Activation of the Drosophila NF‐κB factor Relish by rapid endoproteolytic cleavage
2000
The RING‐finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila
2005
The Drosophila Toll‐9 activates a constitutive antimicrobial defense
2002
Life, death, and the pursuit of apoptosis.
1996
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline
1999 StandoutNobel
Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia
2000 StandoutNobel
Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility
1995
Role of MicroRNAs in Plant and Animal Development
2003 StandoutScienceNobel
dFADD, a Novel Death Domain-containing Adapter Protein for theDrosophila Caspase DREDD
2000
The Toll pathway is important for an antiviral response in Drosophila
2005
Cutting Edge: The Toll Pathway Is Required for Resistance to Gram-Positive Bacterial Infections in Drosophila
2002
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate
2006
Drosophila MyD88 is an adapter in the Toll signaling pathway
2001
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
2001
Melanotic Mutants in Drosophila: Pathways and Phenotypes
2006
A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity
2006
Caspar, a suppressor of antibacterial immunity in Drosophila
2006
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
1996
Drosophila Immunity: Genes on the Third Chromosome Required for the Response to Bacterial Infection
2001
Cell Death Regulation in Drosophila
2000
Biochemical Pathways of Caspase Activation During Apoptosis
1999 Standout
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
2002 StandoutNobel
DNA Repair in Drosophila
2000
Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL
2000
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
DRONC, an ecdysone-inducible Drosophila caspase
1999
An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
1997
Expression of baculovirus P35 prevents cell death in Drosophila
1994
Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.
1987 StandoutNobel
The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection
2006
Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development.
1996
Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster.
1995
Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.
1986
The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila
2006
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Multiple Transcription Start Sites, DNase I-Hypersensitive Sites, and an Opposite-Strand Exon in the 5′ Region of the CHO dhfr Gene
1986
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
1995
A pathway of signals regulating effector and initiator caspases in the developingDrosophilaeye
2002
The Mitochondrion in Cell Death Control: Certainties and Incognita
2000
Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
2005
Innate Immune Recognition
2002 Standout
Essential Role of Survivin, an Inhibitor of Apoptosis Protein, in T Cell Development, Maturation, and Homeostasis
2003
Human DNA Repair Genes
2001 StandoutScienceNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Drosophila : The Genetics of Innate Immune Recognition and Response
2004
A Genetic Screen Targeting the Tumor Necrosis Factor/Eiger Signaling Pathway: Identification of Drosophila TAB2 as a Functionally Conserved Component
2005
Embryonic origin of hemocytes and their relationship to cell death in Drosophila
1994
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Works of John Abrams being referenced
Programmed cell death in Drosophila
1994
Ceramide Generation by the Reaper Protein Is Not Blocked by the Caspase Inhibitor, p35
1998
An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila
2000
Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila
2003
Apoptotic Activity of REAPER Is Distinct from Signaling by the Tumor Necrosis Factor Receptor 1 Death Domain
1996
The Damage-Responsive Drosophila Gene sickle Encodes a Novel IAP Binding Protein Similar to but Distinct from reaper, grim, and hid
2002
Drosophila p53 Binds a Damage Response Element at the reaper Locus
2000
An emerging blueprint for apoptosis in Drosophila
1999
Competition and Compensation
2002 Standout
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
1999
Dredd,a Novel Effector of the Apoptosis ActivatorsReaper, Grim,andHidinDrosophila
1998
Activation of thereaperGene during Ectopic Cell Killing inDrosophila
1996
Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis
2004
Guardian ancestry: fly p53 and damage-inducible apoptosis
2000
Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span
2005
The Apical Caspase dronc Governs Programmed and Unprogrammed Cell Death in Drosophila
2004
The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection
2000
Programmed cell death during Drosophila embryogenesis
1993
Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene.
1985
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
1995
grim, a novel cell death gene in Drosophila.
1996
Genetic Control of Programmed Cell Death in Drosophila
1994 Science
Macrophages in Drosophila embryos and L2 cells exhibit scavenger receptor-mediated endocytosis.
1992
Drosophila p53 preserves genomic stability by regulating cell death
2003
p53: The Janus of autophagy?
2008
Altered Cytochrome c Display Precedes Apoptotic Cell Death in Drosophila
1999