Standout Papers
Citation Impact
Citing Papers
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
Expression of the HPV16 E7 gene generates proliferation in stratified squamous cell cultures which is independent of endogenous p53 levels.
1992
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor
1991
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Bone marrow cells regenerate infarcted myocardium
2001 StandoutNature
Expression of transcription factor E2F1 induces quiescent cells to enter S phase
1993 Nature
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
2010
Synthetic biology: applications come of age
2010
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1
1992
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Roles of ubiquitin-mediated proteolysis in cell cycle control
1997 StandoutNobel
Binding and modulation of p53 by p300/CBP coactivators
1997 Nature
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
1992
The biochemistry of apoptosis
2000 StandoutNature
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
Regulation of Connexin Degradation as a Mechanism to Increase Gap Junction Assembly and Function
2000
Design of gene circuits: lessons from bacteria
2004
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
1991
mUBC9, a Novel Adenovirus E1A-interacting Protein That Complements a Yeast Cell Cycle Defect
1996
Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
1997
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
1997
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Update on hepatitis C virus resistance to direct-acting antiviral agents
2014
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Molecular themes in oncogenesis
1991 StandoutNobel
Oncolytic viruses: adenoviruses
2017
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix
1994 StandoutNobel
Programmed population control by cell–cell communication and regulated killing
2004 StandoutNatureNobel
Effects of activation-defective TBP mutations on transcription initiation in yeast
1994 StandoutNatureNobel
DNA tumor virus transforming proteins and the cell cycle
1993
Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.
1991
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
1993 StandoutNature
Engineered gene circuits
2002 Nature
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
1994 StandoutNobel
Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts
1996 StandoutNobel
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Human Adeno-Associated Virus Type 5 Is Only Distantly Related to Other Known Primate Helper-Dependent Parvoviruses
1999 StandoutNobel
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
STATs and Gene Regulation
1997 StandoutScience
Cancer Cell Cycles
1996 StandoutScience
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
1990
Anaphase-Promoting Complex/Cyclosome–Dependent Proteolysis of Human Cyclin a Starts at the Beginning of Mitosis and Is Not Subject to the Spindle Assembly Checkpoint
2001 StandoutNobel
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Ku is associated with the telomere in mammals
1999 StandoutNobel
Crystal structure of yeast TATA-binding protein and model for interaction with DNA.
1993 StandoutNobel
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
1998 StandoutNobel
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
1993 StandoutNobel
Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.
1995 StandoutNobel
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.
1997
DNA-binding properties of the E1A-associated 300-kilodalton protein.
1992
Multicolor and Electron Microscopic Imaging of Connexin Trafficking
2002 StandoutScienceNobel
Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity
1990
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.
1991
TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
1990
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.
1993
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth
1993
Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins
1991
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Early events in DNA replication require cyclin E and are blocked by p21CIP1.
1995
An essential role for p300/CBP in the cellular response to hypoxia
1996
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
1994 Standout
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
1992
Developmental Control of Cell Cycle Regulators: A Fly's Perspective
1996 Science
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum
1997
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.
1992
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
1992 Science
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.
1993
Identification of distinct roles for separate E1A domains in disruption of E2F complexes.
1993
A distinct cyclin A is expressed in germ cells in the mouse
1996
Works of John A. Howe being referenced
Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen
1989
Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical studies
2013
Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activation
1988
Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120
2008
Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A
1992
Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy
2001
Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.
1988
Induction of the cell cycle in baby rat kidney cells by adenovirus type 5 E1A in the absence of E1B and a possible influence of p53
1993
A developmental timer regulates degradation of cyclin E1 at the midblastula transition during Xenopus embryogenesis.
1996
Mapping of Cellular Protein-Binding Sites on the Products of Early-Region 1A of Human Adenovirus Type 5
1988
Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.
1995 StandoutNobel
Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.
1990