Standout Papers
Citation Impact
Citing Papers
Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
2009 Standout
A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer
2010
Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer
2006
PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer
2014
Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009
2009
Mechanisms of Endocrine Resistance in Breast Cancer
2010
Concordance among Gene-Expression–Based Predictors for Breast Cancer
2006
Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer
2009 Standout
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Biologic markers determine both the risk and the timing of recurrence in breast cancer
2011
Heparin Binding and Oligomerization of Hepatocyte Growth Factor/Scatter Factor Isoforms
1997
Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor.
1994
Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
2011 Standout
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
2010
Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes
2008
Is gene array testing to be considered routine now?
2011
The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
2008
Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer
2014
Hallmarks of Cancer: The Next Generation
2011 Standout
Sulfated Oligosaccharides Promote Hepatocyte Growth Factor Association and Govern Its Mitogenic Activity
1995
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer
2007 Standout
Predictors of Resistance to Preoperative Trastuzumab and Vinorelbine for HER2-Positive Early Breast Cancer
2007
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)
2005
Gene Pathways Associated With Prognosis and Chemotherapy Sensitivity in Molecular Subtypes of Breast Cancer
2010
Inflammation and cancer
2002 StandoutNature
Differential efficacy of three cycles of CMF followed by tamoxifen in patients with ER-positive and ER-negative tumors: Long-term follow up on IBCSG Trial IX
2011
Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 å resolution
1998
Personalized treatment of early-stage breast cancer: Present concepts and future directions
2010
Breast cancer
2016 Standout
Role of tumor-associated macrophages in tumor progression and invasion
2006
Association of a Leukemic Stem Cell Gene Expression Signature With Clinical Outcomes in Acute Myeloid Leukemia
2010
Bacterial Meningitis: Pathogenesis, Pathophysiology, and Progress
1992
Origins of breast cancer subtypes and therapeutic implications
2007
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
2007 Nature
Comparison of the prognostic and predictive utilities of the 21-gene Recurrence Score assay and Adjuvant! for women with node-negative, ER-positive breast cancer: results from NSABP B-14 and NSABP B-20
2011
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Implication of tumor microenvironment in the resistance to chemotherapy in breast cancer patients
2010
Ki-67 as a prognostic marker according to breast cancer subtype and a predictor of recurrence time in primary breast cancer
2010
Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal
1990 StandoutNobel
Surgical Margins in Lumpectomy for Breast Cancer — Bigger Is Not Better
2012
Rheumatoid Arthritis
1990
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
2010 Standout
Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
2008
Analyzing real-time PCR data by the comparative CT method
2008 Standout
Estrogen-Receptor Status and Outcomes of Modern Chemotherapy for Patients With Node-Positive Breast Cancer
2006
Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein
1988 StandoutNatureNobel
Scatter factor/hepatocyte growth factor is essential for liver development
1995 Nature
Regulation of angiogenesis by scatter factor
1997
Chemokine receptors: Structure, function and role in microbial pathogenesis
1996
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
1999
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis
1995
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene‐expression subtypes of breast cancer
2006
High resolution functional analysis of antibody-antigen interactions
1992
Gene expression predictors in breast cancer: Current status, limitations and perspectives
2008
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Identifying Site-specific Metastasis Genes and Functions
2005
Enterochromaffin Cells of the Human Gut: Sensors for Spices and Odorants
2007
Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer
2008
Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer
2013 Standout
Adhesion receptors of the immune system
1990 StandoutNature
The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer
2010
A single-sample microarray normalization method to facilitate personalized-medicine workflows
2012
multifunctional enzymes in cancer
2006
Gene-Expression Signatures in Breast Cancer
2009
Axillary Dissection vs No Axillary Dissection in Women With Invasive Breast Cancer and Sentinel Node Metastasis
2011 Standout
Emergence of vancomycin tolerance in Streptococcus pneumoniae
1999 StandoutNatureNobel
Atherosclerosis — An Inflammatory Disease
1999 Standout
Met, metastasis, motility and more
2003 Standout
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo
1998 StandoutNobel
Molecular evolution and domain structure of plasminogen‐related growth factors (HGF/SF and HGF1/MSP)
1994
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
1991 Standout
Heterogeneity of breast cancer and implications of adjuvant chemotherapy
2007
Ten-year analysis of the prospective multicentre Chemo-N0 trial validates American Society of Clinical Oncology (ASCO)-recommended biomarkers uPA and PAI-1 for therapy decision making in node-negative breast cancer patients
2013
Adjuvant therapies for special types of breast cancer
2011
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
1997 StandoutNatureNobel
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity
1992 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Chemotherapy in Early Breast Cancer: When, How and Which One?
2014
Surgical issues in patients with breast cancer receiving neoadjuvant chemotherapy
2015
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
The prognostic landscape of genes and infiltrating immune cells across human cancers
2015 Standout
First international consensus guidelines for breast cancer in young women (BCY1)
2014
Preservation of Fertility in Patients with Cancer
2009 Standout
Deconstructing the molecular portraits of breast cancer
2010
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
2018 Standout
The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells
2007
Comparison of PAM50 Risk of Recurrence Score With Oncotype DX and IHC4 for Predicting Risk of Distant Recurrence After Endocrine Therapy
2013
CXCL4 mediates tumor regrowth after chemotherapy by suppression of antitumor immunity
2015
Studies on amino acid control of cellular function
1974 StandoutNobel
Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver.
1982 StandoutNobel
Estrogen- and Progesterone-Receptor Status in ECOG 2197: Comparison of Immunohistochemistry by Local and Central Laboratories and Quantitative Reverse Transcription Polymerase Chain Reaction by Central Laboratory
2008
ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA
1984 StandoutNatureNobel
Identification of epidermal growth factor receptors in a hyperproducing human epidermoid carcinoma cell line.
1979
The biochemistry and physiology of the receptor-kinase for epidermal growth factor
1983
Serpin Structure, Mechanism, and Function
2002 Standout
Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.
1986
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Gene Expression Profiling of Breast Cancer: A New Tumor Marker
2005
Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor
1979 StandoutNobel
Direct linkage of epidermal growth factor to its receptor
1979 Nature
Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.
1983
Direct linkage of EGF to its receptor: Characterization and biological relevance
1980
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer
2015
Influence of Cell-free Ascites Fluid and Adenosine 3′5′-Cyclic Monophosphate upon the Cell Kinetics of Ehrlich's Ascites Carcinoma
1973 StandoutNatureNobel
Calcium facilitates endogenous proteolysis of the EGF receptor-kinase
1982
Micrometastatic Disease and Metastatic Outgrowth: Clinical Issues and Experimental Approaches
2009
Controlled proteolysis of EGF receptors: Evidence for transmembrane distribution of the EGF binding and phosphate acceptor sites
1980
A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids
1986 StandoutNobel
Proteolytic cleavage of epidermal growth factor receptor. A Ca2+-dependent, sulfhydryl-sensitive proteolytic system in A431 cells.
1982
Agreement in Breast Cancer Classification between Microarray and Quantitative Reverse Transcription PCR from Fresh-Frozen and Formalin-Fixed, Paraffin-Embedded Tissues
2007
Variations on a theme
1991 StandoutNatureNobel
Molecular probes for the development and plasticity of neural crest derivatives
1985 StandoutNobel
Breast Cancer Subtypes and Response to Docetaxel in Node-Positive Breast Cancer: Use of an Immunohistochemical Definition in the BCIRG 001 Trial
2009
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions*
2000 Standout
Prognostic Significance of Progesterone Receptor–Positive Tumor Cells Within Immunohistochemically Defined Luminal A Breast Cancer
2012
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.
1984
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
1992
Tumor-Associated Lymphocytes As an Independent Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer
2009
Application of the principles of enzyme kinetics to clonal growth rate assays: An approach for delineating interactions among growth promoting agents
1979
Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.
1993
Pharmacogenomic Predictor of Sensitivity to Preoperative Chemotherapy With Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide in Breast Cancer
2006
Difference in the Cyclic Adenosine 3′,5′-Monophosphate Levels in Normal and Transformed Cells
1972
Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor.
1984
Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis
2006 Standout
Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants
1994
Preoperative Chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27
2008
Epidermal Growth Factor
1979 StandoutNobel
A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.
1982 StandoutNobel
Environmental influences in the development of neural crest derivatives: glucocorticoids, growth factors, and chromaffin cell plasticity
1985
Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.
1983
Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.
1984 Standout
Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade
2007
Cassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor
1985 StandoutScienceNobel
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials
2012
Works of Joffre Baker being referenced
Relationship Between Tumor Gene Expression and Recurrence in Four Independent Studies of Patients With Stage II/III Colon Cancer Treated With Surgery Alone or Surgery Plus Adjuvant Fluorouracil Plus Leucovorin
2010
A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients
2006
Prognostic Role of a Multigene Reverse Transcriptase-PCR Assay in Patients with Node-Negative Breast Cancer Not Receiving Adjuvant Systemic Therapy
2005
Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer
2006 Standout
Predicting response to primary chemotherapy: gene expression profiling of paraffin-embedded core biopsy tissue
2006
Measurement of Gene Expression in Archival Paraffin-Embedded Tissues
2004
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
2004 Standout
Expression of the 21 genes in the Recurrence Score assay and tamoxifen clinical benefit in the NSABP study B-14 of node negative, estrogen receptor positive breast cancer
2005
Mechanisms of thrombin‐stimulated cell division
1979
Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions
1989 Science
Thrombin interaction with platelets. Influence of a platelet protease nexin.
1987
Direct linkage of 125I-EGF to cell surface receptors. A useful artifact of chloramine-T treatment.
1982
Thrombin and epidermal growth factor become linked to cell surface receptors during mitogenic stimulation
1979 Nature
Gene Expression Profiles in Paraffin-Embedded Core Biopsy Tissue Predict Response to Chemotherapy in Women With Locally Advanced Breast Cancer
2005
Serum-Stimulated Release of Cell Contacts and the Initiation of Growth in Contact-Inhibited Chick Fibroblasts
1971
Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.
1992
Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells
1980
Purification of human protease nexin.
1983
Evidence that a variety of cultured cells secrete protease nexin and produce a distinct cytoplasmic serine protease‐binding factor
1983
Glucocorticoid‐mediated alteration in growth factor binding and action: Analysis of the binding change
1978
Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding.
1991
Protease nexin. Properties and a modified purification procedure.
1985
Dexamethasone modulates binding and action of epidermal growth factor in serum-free cell culture
1978