Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
S6K1 −/− / S6K2 −/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
2004
Persistent epigenetic differences associated with prenatal exposure to famine in humans
2008 Standout
Akt1 Ablation Inhibits, whereas Akt2 Ablation Accelerates, the Development of Mammary Adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and MMTV-Polyoma Middle T Transgenic Mice
2007
TOR Signaling in Growth and Metabolism
2006 Standout
FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
2010 StandoutNobel
Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain
2010
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy
2004 Standout
Regulation of growth and metabolism by imprinted genes
2006
Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
2011
mTOR Signaling in Growth Control and Disease
2012 Standout
Conditioned reversal of reactions to normally avoided tastes
1990
Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew)
2004
The Tuberous Sclerosis Complex
2006 Standout
A quantitative comparison of taste reactivity behaviors to sucrose before and after lithium chloride pairings: A unidimensional account of palatability.
1992
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
2005 Standout
Adverse Health Effects of Marijuana Use
2014 Standout
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
2003
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
2004 StandoutNobel
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Food reward: Brain substrates of wanting and liking
1996 Standout
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
2010 Standout
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
The deficiency of Akt1 is sufficient to suppress tumor development in Pten +/− mice
2006
Akt-dependent transformation: there is more to growth than just surviving
2005
Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting
2005
A comparison of benzodiazepine, serotonin, and dopamine agents in the taste-reactivity paradigm
1990
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
2004
Autophagy: Renovation of Cells and Tissues
2011 Standout
Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
2007 Standout
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Dietary‐Induced Overeatinga
1989
Neural substrates for conditioned taste aversion in the rat
1994
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Upstream and downstream of mTOR
2004 Standout
Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: Implications for arousal and anhedonia hypotheses of dopamine function.
1989
The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP
2005 Standout
The ATP-gated P2X1 Receptor Plays a Pivotal Role in Activation of Aspirin-treated Platelets by Thrombin and Epinephrine
2008 StandoutNobel
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
Postingestive alliesthesia: The rat tells the same story
1990
Morphine enhances hedonic taste palatability in rats
1993
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
2013 Standout
Chlordiazepoxide nonspecifically enhances consumption of saccharin solution
1991
SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
2007
The Two TORCs and Akt
2007
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
2005
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
2008
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
2009
PI3K/Akt: getting it right matters
2008
An expanding role for mTOR in cancer
2005
Macrophage plasticity and polarization: in vivo veritas
2012 Standout
Tuberous sclerosis complex: from Drosophila to human disease
2004
Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity
2005
What We Talk About When We Talk About Fat
2014 Standout
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
2006
Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B–containing lipoproteins
2008 StandoutNobel
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
2006 Standout
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
The PI3K Pathway in Human Disease
2017 Standout
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
2006
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
1997 StandoutNobel
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster
2003
Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes
2005 StandoutNobel
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
2008
mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells
2004 StandoutNobel
Trigeminal-Taste Interaction in Palatability Processing
1985 Science
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding
2006
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
2004
Chlordiazepoxide directly enhances positive ingestive reactions in rats
1986
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
2014 Standout
Physiological roles of PKB/Akt isoforms in development and disease
2007
Targeted Disruption of the Protein Kinase SGK3/CISK Impairs Postnatal Hair Follicle Development
2004
A circadian gene expression atlas in mammals: Implications for biology and medicine
2014 Standout
The direct enhancement of positive palatability by chlordiazepoxide is antagonized by Ro 15-1788 and CGS 8216
1987
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis
2005
Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis
2004
Environmental Contributions to the Obesity Epidemic
1998 StandoutScience
Control of fluid palatability by exteroceptive Pavlovian signals.
1986
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
2004
Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo
2006 StandoutNobel
Akt isoforms differentially regulate neutrophil functions
2010
Activation of Mammalian Target of Rapamycin in Transformed B Lymphocytes Is Nutrient Dependent but Independent of Akt, Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase, Insulin Growth Factor-I, and Serum
2005
O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling
2011
microRNAs regulate adipocyte differentiation
2013
Isohedonic Tastes Support a Two-dimensional Hypothesis of Palatability
1984
Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies
2006
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size
2005
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
2014
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Akt1 and Akt2 are required for αβ thymocyte survival and differentiation
2007
Role of the Akt pathway in mRNA translation of interferon-stimulated genes
2008
Works of Joel Jacobs being referenced
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
2003
Quality of acquired responses to tastes by Rattus norvegicus depends on type of associated discomfort.
1983