Citation Impact
Citing Papers
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
A completely foreign receptor can mediate an interferon-gamma-like response
2001
Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity
2009
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3
2008
IL-33 Induces IL-13–Dependent Cutaneous Fibrosis
2009
The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines
2008
Janus Kinase (Jak) Subcellular Localization Revisited
2004
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
The alarmin IL-33 promotes regulatory T-cell function in the intestine
2014 Nature
Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase
2014
Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival
2006
Inflammation and cancer
2002 StandoutNature
A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses
2009
Inflammation and metabolic disorders
2006 StandoutNature
From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases
2007
SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice
2001
Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies
2000
The MKK6/p38 Mitogen-Activated Protein Kinase Pathway Is Capable of Inducing SOCS3 Gene Expression and Inhibits IL-6-Induced Transcription
2001
The inflammatory caspases: guardians against infections and sepsis
2006
Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation
2001
IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
2009
SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2
2002
Wound repair and regeneration
2008 StandoutNature
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
The paradigm of IL-6: from basic science to medicine.
2002
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
2007
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
2002
Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1
2006
Inflammatory caspases and inflammasomes: master switches of inflammation
2006
Protein-tyrosine Phosphatase PTPεC Inhibits Jak-STAT Signaling and Differentiation Induced by Interleukin-6 and Leukemia Inhibitory Factor in M1 Leukemia Cells
2000
Interpreting mixed signals: the cell's cytokine conundrum
2011
Pattern Recognition Receptors and Inflammation
2010 Standout
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Clinical applications of 124I-PET/CT in patients with differentiated thyroid cancer
2011
Immunoregulatory functions of mTOR inhibition
2009
The inflammasome: a danger sensing complex triggering innate immunity
2007
Hepatocyte-specific inhibition of NF-κB leads to apoptosis after TNF treatment, but not after partial hepatectomy
2002
PD‐1 signaling in primary T cells
2009
A new high affinity binding site for suppressor of cytokine signaling‐3 on the erythropoietin receptor
2002
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
A Shope Fibroma virus PYRIN-only protein modulates the host immune response
2007
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax Lethal Toxin
2008
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
2003
Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity
2009
IL-6 in Inflammation, Immunity, and Disease
2014 Standout
Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression
2002
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
2002
Immunity, Inflammation, and Cancer
2010 Standout
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
2000
CTLA4 gene polymorphism and autoimmunity
2005
IL‐1, IL‐18, and IL‐33 families of cytokines
2008
Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation
2002
A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction
2000
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Interleukin-33 – cytokine of dual function or novel alarmin?
2009
T helper cell effector fates — who, how and where?
2006
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
2009 Nobel
Different protein turnover of interleukin‐6‐type cytokine signalling components
1999
CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2
2000
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
2009 StandoutNature
Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T Cell Profile
2007
Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
2001
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
2003
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
2001
Coeliac disease: dissecting a complex inflammatory disorder
2002
Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes
2009
A Special Population of Regulatory T Cells Potentiates Muscle Repair
2013
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 StandoutNature
Non-redundant Signal Transduction of Interleukin-6-type Cytokines
2000
Signalling, cell cycle and pluripotency in embryonic stem cells
2002
Global quantification of mammalian gene expression control
2011 StandoutNature
The Interleukin‐1 Receptor Family
2006
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
2007
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
2005 StandoutNature
The role of IL-6 and STAT3 in inflammation and cancer
2005 Standout
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
2006
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Inflammasomes in health and disease
2012 StandoutNature
Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
2001
IL‐1: Discoveries, controversies and future directions
2010
The science of adjuvants
2007
IL-33: A Sheep in Wolf’s Clothing?
2007
Two Different Epitopes of the Signal Transducer gp130 Sequentially Cooperate on IL-6-Induced Receptor Activation
2000
Computational Design of an α-Gliadin Peptidase
2012 StandoutNobel
Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3
2003
The inflammasome in pathogen recognition and inflammation
2007
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
2007
Coordinative Alignment in the Pores of MOFs for the Structural Determination of N-, S-, and P-Containing Organic Compounds Including Complex Chiral Molecules
2019 StandoutNobel
SIGIRR Promotes Resistance againstPseudomonas aeruginosaKeratitis by Down-Regulating Type-1 Immunity and IL-1R1 and TLR4 Signaling
2006
IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes
2008
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130
1999
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation
2004
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985
2000
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Immunological and Inflammatory Functions of the Interleukin-1 Family
2009 Standout
The Inflammatory Caspases: Key Players in the Host Response to Pathogenic Invasion and Sepsis
2006
The Inhibitory Effect of IL-1β on IL-6-Induced α2-Macroglobulin Expression Is Due to Activation of NF-κB
2001
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment
2008
NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
2007
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
2002
Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates its Signal Transduction
2002
IL-33 reduces the development of atherosclerosis
2008
Listeria monocytogenes Modulates Macrophage Cytokine Responses Through STAT Serine Phosphorylation and the Induction of Suppressor of Cytokine Signaling 3
2001
The Inflammasomes: Guardians of the Body
2009 Standout
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
2000
Protective Effect of IL-18 on Kainate- and IL-1β-Induced Cerebellar Ataxia in Mice
2008
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Altered TCR Signaling from Geometrically Repatterned Immunological Synapses
2005 Science
Determination of the Structures of Symmetric Protein Oligomers from NMR Chemical Shifts and Residual Dipolar Couplings
2011 StandoutNobel
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide
2008
Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways
2000
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factorin vivo
2006
Protein tyrosine phosphatase εC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling
2001
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway
2009
A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis
2002
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes
2008 StandoutNobel
Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases
2001
Hepatocyte-specific inhibition of NF-κB leads to apoptosis after TNF treatment, but not after partial hepatectomy
2002
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells
2007
Scar–free healing: from embryonic mechanisms to adult therapeutic intervention
2004
Integrating mechanisms of pulmonary fibrosis
2011 Standout
Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions
2015 StandoutNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Jochen Schmitz being referenced
CTLA-4 gene polymorphism is associated with predisposition to coeliac disease
1998
IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex
2007
SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130
2000
The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction
2000
Expression of suppressors of cytokine signaling during liver regeneration
2001
LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages
1999
The influence of saliva flow stimulation on the absorbed radiation dose to the salivary glands during radioiodine therapy of thyroid cancer using 124I PET(/CT) imaging
2010
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
2002
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
2005 Standout
Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation
2000
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
2004
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
1998
Therapeutic Targeting of Syk in Autoimmune Diabetes
2010