Joan Wither

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

A genomic region associated with protection against severe COVID-19 is inherited from Neandertals

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Platelet factor 4–induced T _H 1-T _reg polarization suppresses antitumor immunity

UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

An Expanded View of Complex Traits: From Polygenic to Omnigenic

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

CD72-Deficient Mice Reveal Nonredundant Roles of CD72 in B Cell Development and Activation

Marginal-zone B cells

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

Semaphorins and their receptors in immune cell interactions

Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity

Recognition of microorganisms and activation of the immune response

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci

Biological Functions of Autophagy Genes: A Disease Perspective

The Makings of a Tumor Rejection Antigen

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

An essential role for Scurfin in CD4+CD25+ T regulatory cells

Dendritic cells in cancer immunology

Novel cancer immunotherapy agents with survival benefit: recent successes and next steps

Measures of systemic sclerosis (scleroderma): Health Assessment Questionnaire (HAQ) and Scleroderma HAQ (SHAQ), Physician‐ and Patient‐Rated Global Assessments, Symptom Burden Index (SBI), University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Scale (UCLA SCTC GIT) 2.0, Baseline Dyspnea Index (BDI) and Transition Dyspnea Index (TDI) (Mahler's Index), Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR), and Raynaud's Condition Score (RCS)

Regulatory T cells in transplantation tolerance

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

Molecular pathogenesis of Bartter’s and Gitelman’s syndromes

The blockade of immune checkpoints in cancer immunotherapy

Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy

SHP-1 Regulation of p62DOK Tyrosine Phosphorylation in Macrophages

A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q

Autoreactivity by design: innate B and T lymphocytes

Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

Inflammation, metaflammation and immunometabolic disorders

In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells

In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB Mice

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade

The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen

The lymphoproliferative defect in CTLA-4–deficient mice is ameliorated by an inhibitory NK cell receptor

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

The future of immune checkpoint therapy

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

Epigenetic Reprogramming in Naive CD4+ T Cells Favoring T Cell Activation and Non‐Th1 Effector T Cell Immune Response as an Early Event in Lupus Flares

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

Autoimmune Alterations Induced by the New Zealand BlackLbw2Locus in BWF1 Mice

Neoantigens in cancer immunotherapy

Characterization of a single-chain T-cell receptor expressed in Escherichia coli.

Uncompensated polyuria in a mouse model of Bartter's syndrome

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells

Ultraviolet radiation and systemic lupus erythematosus

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents

Tolerance is overcome in beef insulin‐transgenic mice by activation of low‐affinity autoreactive T cells

Activated B Cells Express Increased Levels of Costimulatory Molecules in Young Autoimmune NZB and (NZB × NZW)F1 Mice

Both MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response

Patients with systemic autoimmune diseases could not distinguish comorbidities from their index disease

The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1

Amino acid residues in the T cell receptor CDR3 determine the antigenic reactivity patterns of insulin-reactive hybridomas.

Genetic dissection of B cell traits in New Zealand black mice. The expanded population of B cells expressing up-regulated costimulatory molecules shows linkage toNba2

Colocalization of Expansion of the Splenic Marginal Zone Population with Abnormal B Cell Activation and Autoantibody Production in B6 Mice with an Introgressed New Zealand Black Chromosome 13 Interval

Resting B cells from autoimmune lupus-prone New Zealand Black and (New Zealand Black x New Zealand White)F1 mice are hyper-responsive to T cell-derived stimuli.

Functional Dissection of Lupus Susceptibility Loci on the New Zealand Black Mouse Chromosome 1: Evidence for Independent Genetic Loci Affecting T and B Cell Activation