Standout Papers
- Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit (2001)
- Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form (2002)
- Insights into the decoding mechanism from recent ribosome structures (2003)
- STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY (2005)
- Atomic Structures of the 30S Subunit and Its Complexes with Ligands and Antibiotics (2001)
Citation Impact
Citing Papers
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Instruction of Translating Ribosome by Nascent Peptide
2002 Science
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
Specificity of RNA–RNA helix recognition
2002 StandoutNobel
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
Crystal Structure of the Eukaryotic Ribosome
2010 Science
Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
2008 StandoutScienceNobel
Structures of the Bacterial Ribosome at 3.5 A Resolution
2005 Science
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
The Ribosome as a Conveying Thermal Ratchet Machine
2009
Distortion of tRNA upon Near-cognate Codon Recognition on the Ribosome
2011
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Scaffolding as an Organizing Principle in Trans-translation
2006 StandoutNobel
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
tRNA selection and kinetic proofreading in translation
2004 Nobel
How Initiation Factors Maximize the Accuracy of tRNA Selection in Initiation of Bacterial Protein Synthesis
2006
Interactions of elongation factor EF‐P with the Escherichia coli ribosome
2008
A Uniform Response to Mismatches in Codon-Anticodon Complexes Ensures Ribosomal Fidelity
2006
Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy
2003 StandoutNobel
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation
2009 StandoutNobel
Interaction of Translation Initiation Factor 3 with the 30S Ribosomal Subunit
2001
The Structure and Function of the Eukaryotic Ribosome
2012
The ribosome in focus: new structures bring new insights
2007
Amino Acid Starvation and Colicin D Treatment Induce A-site mRNA Cleavage in Escherichia coli
2008
A sequence element that tunes Escherichia coli tRNAAlaGGC to ensure accurate decoding
2009
Mapping Functionally Important Motifs SPF and GGQ of the Decoding Release Factor RF2 to the Escherichia coli Ribosome by Hydroxyl Radical Footprinting
2003
The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome
2006
Cleavage of the A Site mRNA Codon during Ribosome Pausing Provides a Mechanism for Translational Quality Control
2003
Hibernating Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)
2010 Nobel
Ribosomal Proteins S12 and S13 Function as Control Elements for Translocation of the mRNA:tRNA Complex
2003
Mutational analysis reveals two independent molecular requirements during transfer RNA selection on the ribosome
2006
Kinetically Competent Intermediates in the Translocation Step of Protein Synthesis
2007
Structural studies of elongation and release factors
2008
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Functional conformations of the L11–ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulations
2006 StandoutNobel
Automated segmentation of molecular subunits in electron cryomicroscopy density maps
2006
The Spliceosome: Design Principles of a Dynamic RNP Machine
2009 Standout
Suppression of Multiple Substrate Mutations by Spliceosomal prp8 Alleles Suggests Functional Correlations with Ribosomal Ambiguity Mutants
2004
Translation initiation: structures, mechanisms and evolution
2004
Natural amino acids do not require their native tRNAs for efficient selection by the ribosome
2009
The role of modifications in codon discrimination by tRNALysUUU
2004 StandoutNobel
Mechanical Studies of Single Ribosome/mRNA Complexes
2005
The sarcin–ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit
2008
Phylogenetic distribution of translational GTPases in bacteria
2007
Contribution of 16S rRNA nucleotides forming the 30S subunit A and P sites to translation inEscherichia coli
2005
Induced structural changes of 7SL RNA during the assembly of human signal recognition particle
2002
Ribosome as a molecular machine
2002
Structural elements in the internal ribosome entry site of Plautia stali intestine virus responsible for binding with ribosomes
2003
Three-Dimensional Structures of Translating Ribosomes by Cryo-EM
2004
A Model for How Ribosomal Release Factors Induce Peptidyl-tRNA Cleavage in Termination of Protein Synthesis
2007
Elongation factors on the ribosome
2005
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
GTPase activation of elongation factor EF‐Tu by the ribosome during decoding
2009 StandoutNobel
A hierarchical model for evolution of 23S ribosomal RNA
2009 Nature
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
2008
Visualization of the eEF2–80S Ribosome Transition-State Complex by Cryo-Electron Microscopy
2008 StandoutNobel
The involvement of RNA in ribosome function
2002 StandoutNatureNobel
The Geometry of the Ribosomal Polypeptide Exit Tunnel
2006 StandoutNobel
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)
2013 StandoutNobel
The tetracycline resistance protein Tet(○) perturbs the conformation of the ribosomal decoding centre
2002
Structural insights into cognate versus near‐cognate discrimination during decoding
2011 StandoutNobel
Features of Ribosome-Peptidyl-tRNA Interactions Essential for Tryptophan Induction of tna Operon Expression
2005
An Elongation Factor G-Induced Ribosome Rearrangement Precedes tRNA-mRNA Translocation
2003
eIF3j Is Located in the Decoding Center of the Human 40S Ribosomal Subunit
2007 StandoutNobel
A structural understanding of the dynamic ribosome machine
2008 StandoutNobel
Site-specific labeling of the ribosome for single-molecule spectroscopy
2005
Structures of the human and Drosophila 80S ribosome
2013 Nature
Modified Nucleotides in tRNALys and tRNAVal are Important for Translocation
2004
Thiostrepton inhibition of tRNA delivery to the ribosome
2007 Nobel
The Kinetics of Ribosomal Peptidyl Transfer Revisited
2008
Release Factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies
2007
Aminoglycoside activity observed on single pre-translocation ribosome complexes
2009
Structural dynamics of the ribosome
2008
Structure of the E. coli protein-conducting channel bound to a translating ribosome
2005 StandoutNatureNobel
Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex
2002
Recognition and selection of tRNA in translation
2004
Navigating the ribosome's metastable energy landscape
2009
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Unraveling the Structure of the Ribosome (Nobel Lecture)
2010 Nobel
Structural rearrangements of the ribosome at the tRNA proofreading step
2010
Insights into the mechanisms of splicing: more lessons from the ribosome: Figure 1.
2005
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA
2006
Elements of ribosomal drug resistance and specificity
2012 Nobel
Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding
2008 StandoutNobel
Roles of 5-substituents of tRNA wobble uridines in the recognition of purine-ending codons
2003
Mutational Analysis of S12 Protein and Implications for the Accuracy of Decoding by the Ribosome
2007
The Ribosomal Stalk Binds to Translation Factors IF2, EF-Tu, EF-G and RF3 via a Conserved Region of the L12 C-terminal Domain
2006
Conformational Changes of the Small Ribosomal Subunit During Elongation Factor G-dependent tRNA–mRNA Translocation
2004
The ribosome’s response to codon–anticodon mismatches
2006
Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome
2008 StandoutNobel
High-resolution Structures of Ribosomal Subunits: Initiation, Inhibition, and Conformational Variability
2001 StandoutNobel
Identification of Two Distinct Hybrid State Intermediates on the Ribosome
2007
Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements
2006
GTP Hydrolysis by IF2 Guides Progression of the Ribosome into Elongation
2009
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
Kinetic Determinants of High-Fidelity tRNA Discrimination on the Ribosome
2004
Alignment/misalignment hypothesis for tRNA selection by the ribosome
2006
Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease
2001
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
2014 Standout
tRNA’s Wobble Decoding of the Genome: 40 Years of Modification
2006
From the Structure and Function of the Ribosome to New Antibiotics (Nobel Lecture)
2010 Nobel
Crystal structure of the 30 s ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 s RNA
2002 StandoutNobel
The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer
2004 StandoutNobel
Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu
2009 StandoutNobel
Structures of modified eEF2·80S ribosome complexes reveal the role of GTP hydrolysis in translocation
2007 StandoutNobel
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
2005 StandoutNatureNobel
Reverse Translocation of tRNA in the Ribosome
2006
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation
2004 StandoutNobel
Exotoxin A–eEF2 complex structure indicates ADP ribosylation by ribosome mimicry
2005 Nature
Structural basis for messenger RNA movement on the ribosome
2006 Nature
Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process
2002
Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex
2006
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
Deletion of a Conserved, Central Ribosomal Intersubunit RNA Bridge
2006
Study of the Structural Dynamics of the E. coli 70S Ribosome Using Real-Space Refinement
2003 StandoutNobel
The Roles of Ribosomal Proteins in the Structure Assembly, and Evolution of the Large Ribosomal Subunit
2004 StandoutNobel
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit
2003 StandoutNobel
Interaction of Helix D of Elongation Factor Tu with Helices 4 and 5 of Protein L7/12 on the Ribosome
2004
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
2001 StandoutNatureNobel
Following translation by single ribosomes one codon at a time
2008 Nature
A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA
2008
Structural basis for translation termination on the 70S ribosome
2008 Nature
Translocation of tRNA during protein synthesis
2002
Structure of the 80S Ribosome from Saccharomyces cerevisiae—tRNA-Ribosome and Subunit-Subunit Interactions
2001 StandoutNobel
The Path of Messenger RNA through the Ribosome
2001
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit
2008 StandoutNobel
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
What we have learned from ribosome structures
2008 StandoutNobel
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution
2010
Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
2009 StandoutScienceNobel
Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome
2011 StandoutNobel
Crystal structure of a translation termination complex formed with release factor RF2
2008
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
2009 StandoutNobel
The Structural Basis of Large Ribosomal Subunit Function
2003 StandoutNobel
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM
2008 StandoutNobel
The Search and Its Outcome: High-Resolution Structures of Ribosomal Particles from Mesophilic, Thermophilic, and Halophilic Bacteria at Various Functional States
2002 StandoutNobel
Initiation of Protein Synthesis in Bacteria
2005
Structural basis for mRNA and tRNA positioning on the ribosome
2006
Ribosomal Translocation: One Step Closer to the Molecular Mechanism
2009
A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition
2001
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease
2004
The Mechanism for Activation of GTP Hydrolysis on the Ribosome
2010 ScienceNobel
The Molecular Mechanics of Eukaryotic Translation
2004
How Should We Think About the Ribosome?
2012
Intersubunit movement is required for ribosomal translocation
2007
Crystal structure of the β-finger domain of Prp8 reveals analogy to ribosomal proteins
2008
Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates
2004 Standout
Trajectories of the ribosome as a Brownian nanomachine
2014 StandoutNobel
Structural basis for TetM-mediated tetracycline resistance
2012
The role of fluctuations in tRNA selection by the ribosome
2007 Nobel
Translational Operator of mRNA on the Ribosome: How Repressor Proteins Exclude Ribosome Binding
2005 Science
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Irreversible chemical steps control intersubunit dynamics during translation
2008
The ribosome and the mechanism of protein synthesis
2006 StandoutNobel
Role of Ribosomal Protein L27 in Peptidyl Transfer
2008
Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine
2004
The process of mRNA–tRNA translocation
2007 StandoutNobel
RNA Structure: Reading the Ribosome
2005 Science
Translation at the Single-Molecule Level
2008
An Active Role for tRNA in Decoding Beyond Codon:Anticodon Pairing
2005 Science
Structural Basis of the Translational Elongation Cycle
2013 Nobel
Fidelity at the Molecular Level: Lessons from Protein Synthesis
2009
Stop Codon Recognition by Release Factors Induces Structural Rearrangement of the Ribosomal Decoding Center that Is Productive for Peptide Release
2007
Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
2003
Works of J.M. Ogle being referenced
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
Insights into the decoding mechanism from recent ribosome structures
2003 StandoutNobel
Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction
2001
Atomic Structures of the 30S Subunit and Its Complexes with Ligands and Antibiotics
2001 StandoutNobel
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
2002 StandoutNobel
STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY
2005 StandoutNobel