Standout Papers
- Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family (1991)
- Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors (1992)
- Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase. (1987)
- Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. (1990)
- cDNA cloning and chromosomal localization of the human α‐adrenergic receptor kinase (1991)
- Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. (1986)
- Molecular Biology of Adrenergic Receptors (1988)
- The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. (1987)
Citation Impact
Citing Papers
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C
1995
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
2005 StandoutNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Rhodopsin and Phototransduction
1993
Binding of multiple ligands to pleckstrin homology domain regulates membrane translocation and enzyme activity of β‐adrenergic receptor kinase
1997
Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin
1994
Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization
1999
β-arrestins: traffic cops of cell signaling
2004 StandoutNobel
Differences in desensitization between human β1- and β2-adrenergic receptors stably expressed in transfected hamster cells
1995
Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase
1991 StandoutNobel
Identification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-κB Pathways
2004
Interactions of Phosducin with Defined G Protein βγ-Subunits
1996
Regulation of the G Protein-coupled Receptor Kinase GRK5 by Protein Kinase C
1997
Role of phosphorylation in desensitization of the β-adrenoceptor
1990 StandoutNobel
Sequence Alignment of the G-Protein Coupled Receptor Superfamily
1992
Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1
1997 StandoutNobel
Isolation of cDNA Clones Encoding Eight Different Human G Protein γ Subunits, Including Three Novel Forms Designated the γ4, γ10, and γ11 Subunits
1995
Regulation of G Protein-Coupled Receptors by Receptor Kinases and Arrestins
1995
Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization
1996
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
1994
β-Arrestin 1 and Gαq/11 Coordinately Activate RhoA and Stress Fiber Formation following Receptor Stimulation
2004 StandoutNobel
Mutational Analysis of the Pleckstrin Homology Domain of the β-Adrenergic Receptor Kinase.
1995 StandoutNobel
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
2002
Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation
1995 StandoutNobel
Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization
2003 StandoutNobel
Stable Expression of a Truncated AT1A Receptor in CHO-K1 Cells
1995
Gβγ Subunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor
1995 StandoutNobel
Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration
1995
Arresting angiotensin type 1 receptors
2003
Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor
1988
Direct Observation of Endocytosis of Gastrin Releasing Peptide and Its Receptor
1995
Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor
1995 StandoutNobel
Short‐term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways
1992
G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein βγ Subunits
1996
Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C
1996 StandoutNobel
Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase
1998 Nobel
A Central Role for -Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in 2-Adrenergic Receptor Resensitization
1997
The importance of G-protein βλ subunits
1993 StandoutNobel
Regulation of G Protein-coupled Receptor Kinases by Calmodulin and Localization of the Calmodulin Binding Domain
1997
Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor
1995
Phosphorylation of muscarinic receptors: regulation by G proteins
1993
Molecular mechanisms of membrane receptor desensitization
1993
Mitogenic Signaling via G Protein-Coupled Receptors
1996 StandoutNobel
Characterization of the G Protein-coupled Receptor Kinase GRK4
1996 StandoutNobel
Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations
1989
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Phosphorylation and Desensitization of Human Endothelin A and B Receptors
1997 StandoutNobel
Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice
1996 StandoutNobel
Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms
1995
The Role of Sequestration in G Protein-coupled Receptor Resensitization
1997 StandoutNobel
Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor
1996 StandoutNobel
Heterotrimeric C proteins: Organizers of transmembrane signals
1995
Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase
1997
Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin
1996
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
1988 StandoutNatureNobel
Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase
1989
Non-visual GRKs: are we seeing the whole picture?
2003
Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells
2002
β2-Adrenergic Receptor Down-regulation
1999
G Protein-coupled Receptors
1998 StandoutNobel
Myocardial G Protein‐Coupled Receptor Kinases: Implications for Heart Failure Therapy
1999
Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid
1995 StandoutNobel
Seven-transmembrane receptors
2002 StandoutNobel
Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase
1995 StandoutNobel
New roles for G-protein (βγ-dimers in transmembrane signalling
1993 Nature
G protein—coupled receptor kinases
1993 StandoutNobel
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
1994 Nature
Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases
1996 StandoutNobel
Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2
2000
Sequence similarity of phospholipase A2 activating protein and the G protein β-subunits: a new concept of effector protein activation in signal transduction?
1993
G-protein-coupled receptor kinases
1996
Inhibition of G Protein-coupled Receptor Kinase Subtypes by Ca2+/Calmodulin
1996
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases
1996 StandoutNobel
A β-Arrestin-dependent Scaffold Is Associated with Prolonged MAPK Activation in Pseudopodia during Protease-activated Receptor-2-induced Chemotaxis
2003
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain
1992
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
1994 StandoutNobel
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
Palmitoylation of the human β2-adrenergic receptor
1989 StandoutNobel
β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001 StandoutNobel
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.
1993
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
1994 StandoutNobel
Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.
1992
Identification of additional members of human G-protein-coupled receptor kinase multigene family.
1993
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
1995 StandoutNobel
Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase
1993
Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.
1988 StandoutNobel
β 2 -Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
1998 StandoutNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2.
1988 StandoutNobel
Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.
1994 StandoutNobel
Specific enhancement of beta-adrenergic receptor kinase activity by defined G-protein beta and gamma subunits.
1993
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin.
1993
Cardiac Muscarinic Potassium Channel Activity Is Attenuated by Inhibitors of G βγ
1995 StandoutNobel
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
1992 StandoutNobel
The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration
1987
Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide.
1992 StandoutNobel
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
1994
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.
1994
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.
1991
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
1994 StandoutNobel
High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.
1992
Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.
1993
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
2002 StandoutNobel
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
1993 StandoutNobel
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
1994 StandoutNobel
Activation by G protein beta gamma subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin.
1992
Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.
1995
β-Adrenergic Receptor Kinase-2 and β-Arrestin-2 as Mediators of Odorant-Induced Desensitization
1993 StandoutScienceNobel
Binding of G protein beta gamma-subunits to pleckstrin homology domains.
1994 StandoutNobel
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.
1989 StandoutNobel
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity
2000 StandoutNobel
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.
1988 StandoutNobel
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
1992 StandoutNobel
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
Isolation of Drosophila genes encoding G protein-coupled receptor kinases.
1991
Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.
1995
Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.
1994
G proteins and βARK: a new twist for the coiled coil
1993
DESENSITIZATION OF G-PROTEIN–COUPLED RECEPTORS IN THE CARDIOVASCULAR SYSTEM
1999
Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization
1989 StandoutNobel
Synergistic Regulation of β2-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization
1997 StandoutNobel
Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.
1993
Phosphorylation of the N-Formyl Peptide Receptor Carboxyl Terminus by the G Protein-coupled Receptor Kinase, GRK2
1995
Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.
1993
Mechanism of beta-adrenergic receptor kinase activation by G proteins
1993
G PROTEIN βγ SUBUNITS
1997
Binding of Purified Recombinant beta-arrestin to Guanine-Nucleotide-Binding-Protein-Coupled Receptors
1995
Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor
1989 StandoutNobel
Pharmacological Inhibition of Protein Kinases in Intact Cells: Antagonism of Beta Adrenergic Receptor Ligand Binding by H-89 Reveals Limitations of Usefulness
1999
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling
2003 StandoutNobel
Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.
1994
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
G-protein-coupled receptor kinases
1991
Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases
1997 StandoutNobel
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
1991 StandoutNobel
The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2
1993 StandoutNobel
Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.
1993
Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase.
1993
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.
1994
Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.
1993
Site-directed Anti-peptide Antibodies Define the Topography of the β-Adrenergic Receptor
1989
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
1994 StandoutNobel
Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2.
1992
Endocytosis and recycling of G protein-coupled receptors
1997
Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization
1996 Science
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
1999 StandoutNobel
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
1994 StandoutNobel
Regulation of G protein-coupled receptor kinase 2
2002
A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.
1993 StandoutNobel
cAMP-dependent protein kinase and protein kinase C consensus site mutations of the beta-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase.
1994
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
1996
Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.
1991
Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state.
1994
Angiotensin-induced desensitization of the phosphoinositide pathway in cardiac cells occurs at the level of the receptor.
1991
Purification and characterization of rhodopsin kinase.
1988
Desensitization of the human beta 1-adrenergic receptor. Involvement of the cyclic AMP-dependent but not a receptor-specific protein kinase.
1991
Phosphorylation-Independent Desensitization of G Protein-Coupled Receptors?
2002
Binding of Purified Recombinant beta-arrestin to Guanine-Nucleotide-Binding-Protein-Coupled Receptors
1995
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.
1994
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.
1992 StandoutNobel
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.
1993
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
1992 StandoutNobel
Inhibition of the β-Adrenergic Receptor Kinase by Polyanions
1989 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Structure and mechanism of the G protein-coupled receptor kinases.
1993 StandoutNobel
Works of J.L. Benovic being referenced
Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases.
1995
cDNA cloning and chromosomal localization of the human α‐adrenergic receptor kinase
1991 StandoutNobel
β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization
2002
Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6
1995
Regulation of beta-agonist- and prostaglandin E2-mediated adenylyl cyclase activity in human airway epithelial cells.
1994
Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.
1990 StandoutNobel
Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.
1986 StandoutNobel
G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells
2000
Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.
1993
Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.
1987 StandoutNobel
Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family
1991 StandoutNobel
The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.
1987 StandoutNobel
A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.
1994
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel