Standout Papers
Citation Impact
Citing Papers
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints
2002
Chk2 Molecular Interaction Map and Rationale for Chk2 Inhibitors
2006 Nobel
Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions
2008 Science
The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement
2007 StandoutNobel
HERC2 Is an E3 Ligase That Targets BRCA1 for Degradation
2010
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
2003 Nature
MDC1: The art of keeping things in focus
2010
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide from p16CDKN2/INK4A
1996
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
2007 Science
Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Structure and Regulation of the Human Nek2 Centrosomal Kinase
2006
The Tandem BRCT Domain of 53BP1 Is Not Required for Its Repair Function
2006
CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity
2014
Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
2006
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres
2006
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17
2003
Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
2009
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
Common fragile sites
2003
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
Bioluminescent imaging of Cdk2 inhibition in vivo
2004 StandoutNobel
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
2008
The RB and p53 pathways in cancer
2002 Standout
Stability of Checkpoint Kinase 2 Is Regulated via Phosphorylation at Serine 456
2007
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
2007
Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
2009
Unrestricted cell cycling and cancer
1995
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
1995
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
2012
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
2006 Nature
Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies
2003
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
2003 Standout
Revised Subunit Structure of Yeast Transcription Factor IIH (TFIIH) and Reconciliation with Human TFIIH
2003 StandoutNobel
Cellular senescence: when bad things happen to good cells
2007 Standout
Smad transcription factors
2005 Standout
Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection
2014
Regulation of the Cdk inhibitor p27 and its deregulation in cancer
2000
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling
2004
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
2005
Senescence, apoptosis and therapy — cutting the lifelines of cancer
2003
Structural and functional analysis of the Crb2–BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair
2008
Deregulated degradation of the cdk inhibitor p27 and malignant transformation
2002
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
2009 StandoutNobel
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle
1995
p53 — a Jack of all trades but master of none
2009
Intrinsic Kinase Activity and SQ/TQ Domain of Chk2 Kinase as Well as N-terminal Domain of Wip1 Phosphatase Are Required for Regulation of Chk2 by Wip1
2006
Cancer Metastasis: Building a Framework
2006 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody
2003
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Regulation of cell proliferation by Smad proteins
2002
Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function
2006
Cellular Senescence in Cancer and Aging
2007 Standout
A genetic model for colorectal tumorigenesis
1990 Standout
ATM and related protein kinases: safeguarding genome integrity
2003 Standout
The role of transforming growth factor Β in glioma progression
1998
Negative Regulation of Chk2 Expression by p53 Is Dependent on the CCAAT-binding Transcription Factor NF-Y
2004
Cdc25 cell-cycle phosphatase as a target of c-myc
1996 Nature
Telomeres and telomerase in cancer
2009
E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression
2002
ATR: an essential regulator of genome integrity
2008
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
2011 Nature
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
2009
Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation
2002 StandoutNobel
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
MDC1 interacts with Rad51 and facilitates homologous recombination
2005
Global heterochromatin loss
2012
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
Role of autophagy in cancer
2007 Standout
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein
2010 StandoutNobel
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
Checkpoint Kinase 2 (Chk2) Monomers or Dimers Phosphorylate Cdc25C after DNA Damage Regardless of Threonine 68 Phosphorylation
2002
NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage Response
2003
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
1999 StandoutNobel
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
Principles of ubiquitin and SUMO modifications in DNA repair
2009 Nature
Maintenance of the DNA-Damage Checkpoint Requires DNA-Damage-Induced Mediator Protein Oligomerization
2009
Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes
2014
The Chk2 protein kinase
2004
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
2005
RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint
2006
Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation
2004
p53-Dependent apoptosis suppresses tumor growth and progression in vivo
1994
Alterations of the p16-pRb Pathway and the Chromosome Locus 9p21–22 in Non-Small-Cell Lung Carcinomas
1998
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
2000 Standout
Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange
2006
Structure and Activation Mechanism of the CHK2 DNA Damage Checkpoint Kinase
2009
Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1
2008
Blinded by the Light: The Growing Complexity of p53
2009 Standout
DNA Damage, Aging, and Cancer
2009 Standout
Dormancy of Solitary Metastatic Cells
2006
TTK/hMps1 Participates in the Regulation of DNA Damage Checkpoint Response by Phosphorylating CHK2 on Threonine 68
2004
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors
2006
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
1993 Standout
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase
2006
The DNA Damage Response: Ten Years After
2007
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
2009
The p53 tumour suppressor gene
1991 StandoutNature
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
2005
Positional stability of single double-strand breaks in mammalian cells
2007
Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
1995 Standout
Telomere dysfunction and tumour suppression: the senescence connection
2008
FoxO1 is involved in the antineoplastic effect of calorie restriction
2010
Anti‐aging activity of the Ink4/Arf locus
2009
Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer
2010 Standout
TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
2001
Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells
2012
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
2012
p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
2008
Direct Role for the Replication Protein Treslin (Ticrr) in the ATR Kinase-mediated Checkpoint Response
2013 StandoutNobel
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
p53 in health and disease
2007 Standout
Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair
2008
C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells
2006
ATR signaling can drive cells into senescence in the absence of DNA breaks
2008
Chk2 Oligomerization Studied by Phosphopeptide Ligation
2008 StandoutNobel
Structural and Functional Versatility of the FHA Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
2002
Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation
1997
The DNA damage response and cancer therapy
2012 Nature
G1 phase progression: Cycling on cue
1994 Standout
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
2009
The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress
2009
Identification and Characterization of Human MUS81-MMS4 Structure-specific Endonuclease
2003 StandoutNobel
Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer
2004
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
Crystal structure of cyclin-dependent kinase 2
1993 Nature
TGFβ in Cancer
2008 Standout
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
2001
Policing of oncogene activity by p53
2006 Nature
Principles of CDK regulation
1995 StandoutNature
Oncogene-induced senescence: the bright and dark side of the response
2010
Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
2009
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
2009
Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas
1995
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
2007 StandoutNobel
The anaphase-promoting complex: it's not just for mitosis any more
2002
H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations
2006
The Anaphase-Promoting Complex
2002
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
2007
Regulation of Claspin degradation by the ubiquitin‐proteosome pathway during the cell cycle and in response to ATR‐dependent checkpoint activation
2006
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
2007
Early events in the mammalian response to DNA double-strand breaks
2008
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain
2002
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.
1997
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
2007
Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway
2005
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
2005 StandoutNature
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage
2008
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1999 StandoutNobel
A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras
1999
Transcriptional regulation and transformation by Myc proteins
2005
Genomic instability — an evolving hallmark of cancer
2010 Standout
The Hallmarks of Aging
2013 Standout
Autophosphorylated Residues Involved in the Regulation of Human Chk2 In Vitro
2008
Cyclins and cdks in development and cancer: a perspective
2005
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
Chk1 is required to maintain Claspin stability
2006
The Causes and Consequences of Polyploidy in Normal Development and Cancer
2011
The Stress Kinase MRK Contributes to Regulation of DNA Damage Checkpoints through a p38γ-independent Pathway
2004
Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression
2008
TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest
1993
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
2002 Nature
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
1996
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
2007
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation
2008
The Tumor Suppressor Protein p16 and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System
2004 StandoutNobel
Co-evolution of tumor cells and their microenvironment
2008
Of flies and men; p53, a tumour suppressor
2004
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
1993 Nature
DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer
2010
Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response
2005
Human Tim/Timeless-interacting Protein, Tipin, Is Required for Efficient Progression of S Phase and DNA Replication Checkpoint
2006
Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
1994
Lack of PTEN sequesters CHK1 and initiates genetic instability
2005
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Genome editing with engineered zinc finger nucleases
2010 Standout
The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
2003
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
DNA Damage Foci at Dysfunctional Telomeres
2003
Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer
1996
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
Cellular senescence: hot or what?
2009
Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)
2011 StandoutNobel
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Stimulation of c‐MYC transcriptional activity and acetylation by recruitment of the cofactor CBP
2003
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
2008
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.
1996
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.
1992
Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G1/S-Regulatory Genes
1995
Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.
1994
p53 C-Terminal Phosphorylation by CHK1 and CHK2 Participates in the Regulation of DNA-Damage-induced C-Terminal Acetylation
2005
p53 Mutations in Human Cancers
1991 StandoutScience
Rescue of defective mitogenic signaling by D-type cyclins.
1995
Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 INK4
1995 Science
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.
1993
Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.
1996
Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors
1996 StandoutNobel
Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach
2002
Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events
1996
Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control
1993 Science
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
1994 StandoutScience
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
A FoxO–Smad synexpression group in human keratinocytes
2006
Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G1 Progression in NIH 3T3 cells
1995
Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and Senescence
1996
Activation of Cyclin-Dependent Kinase 4 (cdk4) by Mouse MO15-Associated Kinase
1994
Cancer Cell Cycles
1996 StandoutScience
Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins
2007
Profiling of UV-induced ATM/ATR signaling pathways
2007
NFBD1/MDC1 regulates ionizing radiation‐induced focus formation by DNA checkpoint signaling and repair factors
2003
Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells
2012
Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
1994
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
1990 StandoutScience
An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage
2002
Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
2009
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
2001
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
2005
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
2009
Chk2 Activation and Phosphorylation-Dependent Oligomerization
2002
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
1993
Four faces of cellular senescence
2011 Standout
Activation of p53 by MDM2 Antagonists Can Protect Proliferating Cells from Mitotic Inhibitors
2005
Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage
1996 Science
Altered Cell Cycle Kinetics, Gene Expression, and G1 Restriction Point Regulation in Rb-Deficient Fibroblasts
1996
Phospho‐dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
2008
Effects of Phosphorylation by CAK on Cyclin Binding by CDC2 and CDK2
1995
Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
2008
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
2003
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
Posttranslational Modifications of p53 in Replicative Senescence Overlapping but Distinct from Those Induced by DNA Damage
2000
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
2003
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts
2007 Nobel
Regulation of the cyclin E gene by transcription factor E2F1.
1995
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
2005
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
2000
MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.
1995
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
2007
An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks
2008
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
1995
Chromatin remodeling by nucleosome disassembly in vitro
2006 StandoutNobel
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
1998
Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin.
2003
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
DNA replication licensing and human cell proliferation
2001
Mechanism and Regulation of Class Switch Recombination
2008
Structure and Function of the Phosphothreonine-Specific FHA Domain
2008
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition.
1994
D-type cyclin-dependent kinase activity in mammalian cells.
1994
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Cyclin D1 Is Dispensable for G1 Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity
1995
Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6
1995
DNA Damage Responses: Mechanisms and Roles in Human Disease
2008
Expression and activity of p40MO15, the catalytic subunit of cdk-activating kinase, during Xenopus oogenesis and embryogenesis.
1994
The Use of In Vitro Peptide-Library Screens in the Analysis of Phosphoserine/Threonine-Binding Domain Structure and Function
2004
HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.
1996
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
1996
Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response
2011
The INK4a/ARF locus and melanoma
2003
Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
2010
A p16 INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma
1995 Science
Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage
1996
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
1994
MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH.
1996
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.
2002
Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function
2006
The Arf/p53 Pathway in Cancer and Aging
2008
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
1990 StandoutScience
Non-homologous end-joining, a sticky affair
2007
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
1994 Standout
Recruitment of DNA Damage Checkpoint Proteins to Damage in Transcribed and Nontranscribed Sequences
2005 StandoutNobel
Works of Jiří Bártek being referenced
Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
2007
Inhibition of Chk1 by CEP-3891 Accelerates Mitotic Nuclear Fragmentation in Response to Ionizing Radiation
2004
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
2005
The DNA-damage response in human biology and disease
2009 StandoutNature
DNA damage checkpoints: from initiation to recovery or adaptation
2007
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
2011
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1995 Nature
DNA Damage Response as an Anti-Cancer Barrier: Damage Threshold and the Concept of 'Conditional Haploinsufficiency'
2007
Cell-cycle checkpoints and cancer
2004 StandoutNature
Chk1 and Chk2 kinases in checkpoint control and cancer
2003
Efficient transfer of antibodies into mammalian cells by electroporation
1994
Alternative splicing and mutation status of CHEK2 in stage III breast cancer
2004
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation
2004
Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention
2004
Chk2 kinase — a busy messenger
2001
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress
2006
Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients
2004
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
2006
Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc
1997
Repression of p15INK4b expression by Myc through association with Miz-1
2001
Deregulation of the G1/S‐phase control in human testicular germ cell tumours
2003
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
1999 Nature
Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro
1990
Aberrations of p16Ink4 and retinoblastoma tumour‐suppressor genes occur in distinct sub‐sets of human cancer cell lines
1995
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a
2011
An immunochemical analysis of the human nuclear phosphoprotein p53
1992
Substrate Specificity and Cell Cycle Regulation of the Nek2 Protein Kinase, a Potential Human Homolog of the Mitotic Regulator NIMA of Aspergillus nidulans
1995
Human Xip1 (C2orf13) Is a Novel Regulator of Cellular Responses to DNA Strand Breaks
2007
Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase
2004
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation
2003
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
2009
Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer
2004
The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways
2002
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
2003
Checking on DNA damage in S phase
2004
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
2002
The CHEK2 gene and inherited breast cancer susceptibility
2006
DNA damage signalling guards against activated oncogenes and tumour progression
2007
Increased expression of mutant forms of p53 oncogene in primary lung cancer
1990
MDC1 is required for the intra-S-phase DNA damage checkpoint
2003 Nature
Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
2001
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
2011
CHEK2 variant I157T may be associated with increased breast cancer risk
2004
Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer
1995
Aberrations of the G1- and G1/S-regulating genes in human cancer
1997
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
2003
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
2005
Human Asf1 Regulates the Flow of S Phase Histones during Replicational Stress
2005
Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway
2004
Cyclin D1 protein expression and function in human breast cancer
1994
The PRAD‐1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas
1994
Human CtIP promotes DNA end resection
2007 Nature
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
2009
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
2002
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
2006
E2F activity is essential for survival of Myc-overexpressing human cancer cells
2002
Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts
1996
The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
2001 Nature
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
2007
DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
2007
Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response
2010
Mammalian G1- and S-phase checkpoints in response to DNA damage
2001
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
2005
Aberrant p21CIP1/WAF1 protein accumulation in head-and-neck cancer
1997
A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast Cancer
2002
The combined status of ATM and p53 link tumor development with therapeutic response
2009
Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time
2004
Targeting the checkpoint kinases: chemosensitization versus chemoprotection
2004
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
2001
Modulation of the E2F1-Driven Cancer Cell Fate by the DNA Damage Response Machinery and Potential Novel E2F1 Targets in Osteosarcomas
2009
Imaging of protein movement induced by chromosomal breakage: tiny ‘local’ lesions pose great ‘global’ challenges
2005
Rapid Destruction of Human Cdc25A in Response to DNA Damage
2000 Science
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.
1996
BCL-1/cyclin D1 oncoprotein oscillates and subverts the G1 phase control in B-cell neoplasms carrying the t(11;14) translocation.
1994
Watching the DNA Repair Ensemble Dance
2004
Evidence for a Telomere-Independent “Clock” Limiting RAS Oncogene-Driven Proliferation of Human Thyroid Epithelial Cells
2000
The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.
1996
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin
2008
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.
1993
An Oncogene-Induced DNA Damage Model for Cancer Development
2008 Science
Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle
2000
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
2006
Cyclin D1 expression is regulated by the retinoblastoma protein.
1994
Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage
2005
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.
2001
Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5
1994
Cyclin E-induced S phase without activation of the pRb/E2F pathway.
1997
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).
1994
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.
1995
Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.
1990
Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation
2006
Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control.
1995
Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis.
1995
ATR, Claspin and the Rad9-Rad1-Hus1 Complex Regulate Chk1 and Cdc25A in the Absence of DNA Damage
2004
Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.
1991
Transforming Growth Factor β1Selectively Inhibits the Cyclic AMP-dependent Proliferation of Primary Thyroid Epithelial Cells by Preventing the Association of Cyclin D3–cdk4 with Nuclear p27kip1
2000
DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.
1994
A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex–Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression
2001
Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis
2000
p27 destruction: Cks1 pulls the trigger
2001
Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization
1997
Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway
2000