Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2008 StandoutScience
The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy
2016
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
2014 Science
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
2014 Science
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
2009 Standout
Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
2008 StandoutScience
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
2006 StandoutScience
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
2016
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
2015
Fully Metallated S134N Cu,Zn-Superoxide Dismutase Displays Abnormal Mobility and Intermolecular Contacts in Solution
2005
Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria
2004
M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice
2006
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Disease-Specific Induced Pluripotent Stem Cells
2008 Standout
R loops: new modulators of genome dynamics and function
2015
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
2008
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
2003
Familial Amyotrophic Lateral Sclerosis Mutants of Copper/Zinc Superoxide Dismutase Are Susceptible to Disulfide Reduction
2003
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
ALS Mutants of Human Superoxide Dismutase Form Fibrous Aggregates Via Framework Destabilization
2003
Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis
2013
Amyotrophic Lateral Sclerosis Mutations Have the Greatest Destabilizing Effect on the Apo- and Reduced Form of SOD1, Leading to Unfolding and Oxidative Aggregation
2005
Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways
2015
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
2007
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003
Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice
2005
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
2006
Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-SynucleinopathyIn Vivo
2012
Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model
2007
Amyotrophic lateral sclerosis
2011 Standout
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
2015
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
2016
Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA
2015
Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
2015
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
2008
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
2007 Standout
Decoding ALS: from genes to mechanism
2016 StandoutNature
RNA-binding proteins in neurodegeneration: Seq and you shall receive
2015
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS
2003
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation
2012
Protein folding and misfolding
2003 StandoutNature
Mitochondrial Localization of Mutant Superoxide Dismutase 1 Triggers Caspase-dependent Cell Death in a Cellular Model of Familial Amyotrophic Lateral Sclerosis
2002
Cellular Strategies of Protein Quality Control
2011
Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord
2005
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Fluorescent indicators based on BODIPY
2011 Standout
Alzheimer's disease
2006 Standout
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS
2014
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
2005
Alzheimer's Disease
2010 Standout
Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis
2005
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
A Fresh Look at iPS Cells
2009 StandoutNobel
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
2014
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes
2003
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion
2014
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2–21.3
2006
Dorfin Localizes to the Ubiquitylated Inclusions in Parkinson's Disease, Dementia with Lewy Bodies, Multiple System Atrophy, and Amyotrophic Lateral Sclerosis
2003
Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis
2004
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
2006
The structural biochemistry of the superoxide dismutases
2009
Aggregation-induced emission
2011 Standout
Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers
2016
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
2006
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
On the Relation of Oxidative Stress to Neuroinflammation: Lessons Learned from the G93A-SOD1 Mouse Model of Amyotrophic Lateral Sclerosis
2006
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
2006
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Superoxide Dismutases and Superoxide Reductases
2014
Protein Misfolding, Functional Amyloid, and Human Disease
2006 Standout
Copper Active Sites in Biology
2014 Standout
PROTOFIBRILS , PORES , FIBRILS, AND NEURODEGENERATION : Separating the Responsible Protein Aggregates from The Innocent Bystanders
2003
Luminescent Chemodosimeters for Bioimaging
2012 Standout
Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models
2007
Misfolded CuZnSOD and amyotrophic lateral sclerosis
2003
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
2017
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
2018
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
2016
Luminescent Functional Metal–Organic Frameworks
2011 Standout
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
Walking the tightrope: proteostasis and neurodegenerative disease
2016
Bioinorganic Chemistry of Alzheimer’s Disease
2012
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Superoxide Ion: Generation and Chemical Implications
2016 Standout
Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives
2011 Standout
Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL
2006
2016
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis
2009
Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast‐derived iPS cells using zinc‐finger nuclease technology
2015
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
2011
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
2004
GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function
2015
COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS
2003
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
2015
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis
2005
Works of Jiou Wang being referenced
Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA
2005
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
2013
Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature
2003
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation
2005
An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans
2009
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
2014 Nature
Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases
2007
Disease-associated Mutations at Copper Ligand Histidine Residues of Superoxide Dismutase 1 Diminish the Binding of Copper and Compromise Dimer Stability
2006
Mapping superoxide dismutase 1 domains of non‐native interaction: roles of intra‐ and intermolecular disulfide bonding in aggregation
2006
Fibrillar Inclusions and Motor Neuron Degeneration in Transgenic Mice Expressing Superoxide Dismutase 1 with a Disrupted Copper-Binding Site
2002
Transgenic mouse models of neurodegenerative disease: Opportunities for therapeutic development
2002
High Molecular Weight Complexes of Mutant Superoxide Dismutase 1: Age-Dependent and Tissue-Specific Accumulation
2002
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS
2009