Citation Impact
Citing Papers
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Convergence of Multiple Autophagy and Cytoplasm to Vacuole Targeting Components to a Perivacuolar Membrane Compartment Prior tode Novo Vesicle Formation
2002
Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin
2003
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State
2005
Therapeutic strategies for Alzheimer's disease
2002
Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor
2004
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities
2005
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
2002
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
2003 Nature
The presenilins and Alzheimer's disease
1997
Regulation of Notch signalling by non-visual β-arrestin
2005
Autophagy regulates lipid metabolism
2009 StandoutNature
T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling
2004
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
2006 Nature
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Autophagy and neurodegeneration: when the cleaning crew goes on strike
2007
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation
2003
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain
2003
Uptake and pathogenic effects of amyloid beta peptide 1–42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists
2002
The biochemistry of apoptosis
2000 StandoutNature
Huntingtin localization in brains of normal and Huntington's disease patients
1997
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
2002
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
2009 StandoutNobel
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide
2002
Notch signalling: a simple pathway becomes complex
2006 Standout
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Protein Degradation: Four E3s For The Notch Pathway
2002
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
2000
γ-Secretase Complex Assembly within the Early Secretory Pathway
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
2005
Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects
1999
Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
1999
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
2006
Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta
2003
PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1
2003
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Cathepsin D—Many functions of one aspartic protease
2008
The structural basis of function in Cys-loop receptors
2010
Oncogenic aberrations of cullin-dependent ubiquitin ligases
2004
Lysosomal Activation Is a Compensatory Response Against Protein Accumulation and Associated Synaptopathogenesis—An Approach for Slowing Alzheimer Disease?
2003
Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein
2005
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin
2003
Caspase-independent programmed cell death with necrotic morphology
1999
Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model
2004
Evidence That Assembly of an Active γ-Secretase Complex Occurs in the Early Compartments of the Secretory Pathway
2004
Intracellular amyloid-β in Alzheimer's disease
2007 Standout
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex
2003
Variations on the Notch pathway in neural development
2002
APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes
2003
Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage
2002
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation
1998
PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin
2002
The role of presenilin cofactors in the γ-secretase complex
2003 Nature
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Aggresomes: A Cellular Response to Misfolded Proteins
1998 Standout
The initial substrate-binding site of γ-secretase is located on presenilin near the active site
2005
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway
1999
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
Presenilin 1 Negatively Regulates β-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of β-Amyloid Precursor Protein and Notch Processing
2001
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
2000
Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1
2004
CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
2005
The ubiquitin ligaseDrosophilaMind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
2005
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
2005
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals
2003
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand
2003
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.
1997
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Organosilicon Biotechnology
2009
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice
2003
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity
2000
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved
2007
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors
2002
Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
2003
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Notch: a membrane-bound transcription factor
2002
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
2017
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Cancer Genome Landscapes
2013 StandoutScience
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Mitotic Misregulation and Human Aging
2000 Science
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α
2011
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
1997 StandoutScience
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
2010
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
1999
The interplay between DSL proteins and ubiquitin ligases in Notch signaling
2005
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
1999 Science
Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis
1997
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
1999
Regulation of Notch Signaling Activity
2004
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Jinhe Li being referenced
The unique skeleton of siliceous sponges (Porifera; Hexactinellida and Demospongiae) that evolved first from the Urmetazoa during the Proterozoic: a review
2007
Structure and alternative splicing of the Presenilin-2 gene
1996
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation
2002
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
1995
The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog
2001
Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment
2008
Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation
1997
Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model
2003
SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation
2001