Standout Papers

A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits 1995 2026 2005 2015 242
  1. A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits (1995)
    Jianqiang Chen, Michael J. DeVivo et al. Science

Citation Impact

Citing Papers

Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
2008 StandoutNobel
Tailoring cAMP-signalling responses through isoform multiplicity
1997
Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation
1995
Interactions of Phosducin with Defined G Protein βγ-Subunits
1996
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans
2004 StandoutNobel
Phospholipase D in rat myometrium: occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by βγ subunits of heterotrimeric G-proteins
2000
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
2003 StandoutNobel
Proteasome inhibitors: from research tools to drug candidates
2001
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
The ubiquitin-proteasome pathway in cancer
1998
The Many Faces of G Protein Signaling
1998
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Synthesis and activity of pyrrolidinyl- and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi
2000
Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
2004 Standout
Photonic structures in biology
2003 StandoutNature
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Complexity and Diversity of Mammalian Adenylyl Cyclases
1996 Nobel
Phosducin, Potential Role in Modulation of Olfactory Signaling
1997 StandoutNobel
Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia
1999 StandoutNobel
Regulation of apoptosis by the ubiquitin and proteasome pathway
2002
Structural Basis of Inward Rectification
2002 StandoutNobel
Identification of critical amino acids involved in α1β interaction in voltage‐dependent Ca2+ channels
1996
Thrombin signalling and protease-activated receptors
2000 StandoutNature
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
The adenylyl and guanylyl cyclase superfamily
1998
Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase
1998 Nobel
G Protein Heterodimers: New Structures Propel New Questions
1996
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
A Role for cAMP in Long-Term Depression at Hippocampal Mossy Fiber Synapses
1998 StandoutNobel
Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae)
2018 StandoutNobel
Heterotrimeric G proteins
1996
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Modulation of Ca2+ channels βγ G-protein py subunits
1996 Nature
Calmodulin Suppresses Synaptotagmin-2 Transcription in Cortical Neurons*
2010 StandoutNobel
PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis
2005
β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics
2007 StandoutNobel
The Proteasome
2001
Intracellular Proteinases of Invertebrates: Calcium-Dependent and Proteasome/Ubiquitin-Dependent Systems
1998
Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome
1999
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The proteasome: a suitable antineoplastic target
2004
Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes
2002 StandoutNobel
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels
2009
A Domain on the G Protein β Subunit Interacts with Both Adenylyl Cyclase 2 and the Muscarinic Atrial Potassium Channel
1996
Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits
1996 Nature
Association of Neuronal Calcium Channels with Modular Adaptor Proteins
1999 StandoutNobel
G Protein Modulation of Voltage-Gated Calcium Channels
2003
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
NF-κB p105 Processing via the Ubiquitin-Proteasome Pathway
1998
Expression of Phosducin in a Phosducin-negative Cell Line Reveals Functions of a Gβγ-binding Protein
1996
Chapter 11 Proteinase families and their inhibitors
2001
Proteasome inhibitors: fromin vitro uses to clinical trials
2000
Preservation of Fertility in Patients with Cancer
2009 Standout
Dosage‐dependent switch from G protein‐coupled to G protein‐independent signaling by a GPCR
2006 StandoutNobel
Noncovalent Functionalization of Graphene and Graphene Oxide for Energy Materials, Biosensing, Catalytic, and Biomedical Applications
2016 Standout
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Direct interaction of Gβγ with a C-terminal Gβγ-binding domain of the Ca 2+ channel α 1 subunit is responsible for channel inhibition by G protein-coupled receptors
1997
Mechanism of specific nuclear transport of adriamycin: the mode of nuclear translocation of adriamycin-proteasome complex.
2001
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes
2000 StandoutNobel
Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes.
2000
Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTPγS-stimulated polymorphonuclear leukocytes
2003 StandoutNobel
Compartmentation of Cyclic Nucleotide Signaling in the Heart
2006
G PROTEIN βγ SUBUNITS
1997
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
Superoxide Ion: Generation and Chemical Implications
2016 Standout
PRESYNAPTIC RECEPTORS
1998
Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases
1997 StandoutNobel
Rapid Deubiquitination of Nucleosomal Histones in Human Tumor Cells Caused by Proteasome Inhibitors and Stress Response Inducers:  Effects on Replication, Transcription, Translation, and the Cellular Stress Response
1997
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Emerging Targets in Photopharmacology
2016 StandoutNobel
Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G ·GTPγS
1997 ScienceNobel
Identification of the binding site for Gqα on its effector Bruton’s tyrosine kinase
1998
Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A
2001
Multiple Myeloma
2011 Standout
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes
2000 StandoutNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Destruction of Chlorinated Phenols by Dioxygen Activation under Aqueous Room Temperature and Pressure Conditions
2003
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Level of β-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload–Induced Heart Failure
2005 StandoutNobel

Works of Jingrong Li being referenced

The Antitumor Drug Aclacinomycin A, Which Inhibits the Degradation of Ubiquitinated Proteins, Shows Selectivity for the Chymotrypsin-like Activity of the Bovine Pituitary 20 S Proteasome
1996
Inhibition of Prolyl Oligopeptidase by Fmoc‐Aminoacylpyrrolidine‐2‐Nitriles
1996
Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues
2014
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Gα s  stimulation
1997
Rankless by CCL
2026