Standout Papers
Citation Impact
Citing Papers
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
2017
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
2019
Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death
2018
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
2016 Science
The repertoire of glycan determinants in the human glycome
2009
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming
2018
2016
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly
2019
Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K + efflux
2015
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion
2018
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells
2019
A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
2019
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
2015
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells
2018
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
2018
The role of pyroptosis in cancer: pro-cancer or pro-“host”?
2019
Caspase-1 initiates apoptosis in the absence of gasdermin D
2019
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
2016
Gasdermin: A new player to the inflammasome game
2017
‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death
2017
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
2020
Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis
2018
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
2020
Malignant Helicobacter pylori-Associated Diseases: Gastric Cancer and MALT Lymphoma
2019
NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8
2017
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
2020
Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia
2020
Necroptosis and its role in inflammation
2015 StandoutNature
Pyroptosis
2016
The role of inflammasomes in kidney disease
2019
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation
2019
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
2018
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Bacterial Exotoxins and the Inflammasome
2015
COPs and POPs Patrol Inflammasome Activation
2017
Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa
2018
Converging roles of caspases in inflammasome activation, cell death and innate immunity
2015
Mechanism and Regulation of NLRP3 Inflammasome Activation
2016 Standout
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
2017
Modulation of Siglec-7 Signaling Via In Situ-Created High-Affinity cis-Ligands
2021
Death by TNF: a road to inflammation
2022
Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions
2017
Targeting Ferroptosis to Iron Out Cancer
2019 Standout
Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization
2019
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
2017 Standout
β-Propeller Blades as Ancestral Peptides in Protein Evolution
2013
The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
2018
The Coming Decade of Cell Death Research: Five Riddles
2019
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages
2017
Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation
2019
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
2017 StandoutNobel
Inflammasome Complexes: Emerging Mechanisms and Effector Functions
2016
The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection
2018
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
2015
Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer
2018
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
2017
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
2015
HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome
2020
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
2018
Immunogenic cell death in cancer and infectious disease
2016 Standout
GSDMD is required for effector CD8+ T cell responses to lung cancer cells
2019
The molecular machinery of regulated cell death
2019 Standout
Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium
2015
Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation
2016
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Gasdermin E suppresses tumour growth by activating anti-tumour immunity
2020 Nature
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis
2016
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis
2016
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes
2016
Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis
2016
Mechanisms of inflammasome activation: recent advances and novel insights
2015
Salmonellae interactions with host processes
2015
Differential roles of caspase-1 and caspase-11 in infection and inflammation
2017
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
Inflammasomes and the fine line between defense and disease
2019
Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro
2019
Pyroptosis: mechanisms and diseases
2021 Standout
NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies
2017
Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
2017
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
2017
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
2016
Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells
2016
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
GSDME mediates caspase-3-dependent pyroptosis in gastric cancer
2017
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
2018
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
2019
Diverging inflammasome signals in tumorigenesis and potential targeting
2019
Pyroptosis: A new frontier in cancer
2019 Standout
Gastric cancer
2020 Standout
Caspases and their substrates
2017
Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity
2015
Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
2019
Gut microbiota, metabolites and host immunity
2016 Standout
Photoaging and skin cancer: Is the inflammasome the missing link?
2018
Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions
2013
Post-Translational Modification Control of Innate Immunity
2016
Mitochondria as multifaceted regulators of cell death
2019 Standout
Caspases Connect Cell-Death Signaling to Organismal Homeostasis
2016
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
2016 Standout
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
Caspase crosstalk: integration of apoptotic and innate immune signalling pathways
2014
Programmed cell death as a defence against infection
2017
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
2018
Non-apoptotic cell death in malignant tumor cells and natural compounds
2018
Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence
2015
Gasdermins: Effectors of Pyroptosis
2017 Standout
Ferroptosis and Necroptosis in the Kidney
2020
IAPs and Cell Death
2016
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer
2016
A systems approach to infectious disease
2020
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
2015 Standout
Glycosylation in cancer: mechanisms and clinical implications
2015 Standout
Human Monocytes Engage an Alternative Inflammasome Pathway
2016
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation
2018
Role of pyroptosis in cardiovascular diseases
2018
Plasma membrane changes during programmed cell deaths
2017
Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture
2018
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
2018 Science
Pfam: The protein families database in 2021
2020 Standout
Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein
2017
DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages
2019
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
2016
Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity
2016
cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis
2019
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
2017 Standout
Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages
2015
Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage
2019
Beclin-1-Dependent Autophagy Protects the Heart During Sepsis
2018
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
2019 Standout
Post-translational regulation of inflammasomes
2016
Caspase-11 Modulates Inflammation and AttenuatesToxoplasma gondiiPathogenesis
2016
Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH
2020
The NLRP1 Inflammasome in Human Skin and Beyond
2020
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Pyroptotic cell death defends against intracellular pathogens
2015
Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
2020
Gasdermins and their role in immunity and inflammation
2019
Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
2020
IRF2 transcriptionally induces GSDMD expression for pyroptosis
2019
Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
2017
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways
2020
The Hallmarks of Ferroptosis
2018
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
2018 StandoutNobel
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis
2019
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
2018
Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture
2015
Cytokine Storm
2020 Standout
Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
2020
Single Crystals Heterogeneity Impacts the Intrinsic and Extrinsic Properties of Metal–Organic Frameworks
2021 StandoutNobel
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
2019
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
2018
Caspase‐4 mediates non‐canonical activation of the NLRP3 inflammasome in human myeloid cells
2015
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5
2015
Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death
2015
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
2018
Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer
2018
Caspase‐11: arming the guards against bacterial infection
2015
Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles
2016
Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
2015 Science
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
2016
Biochemical Properties and Roles of DprA Protein in Bacterial Natural Transformation, Virulence, and Pilin Variation
2023
The NLRP 1 inflammasomes
2015
Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer
2018
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
To the edge of cell death and back
2018
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
2017
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
2019 Standout
Three-dimensional Ca 2+ imaging advances understanding of astrocyte biology
2017 Science
The NAIP –NLRC 4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus
2015
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
2018
An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy
2018
Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
2015
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
2018
Reassessing the Evolutionary Importance of Inflammasomes
2016
Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation
2016
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
2018
Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle‐related proteins
2018
Regulation of inflammasome activation
2015
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
2019
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
2016
GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
2018
Programmed necrosis in inflammation: Toward identification of the effector molecules
2016 Science
Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo
2015
Caspases in Cell Death, Inflammation, and Pyroptosis
2020
Works of Jingjin Ding being referenced
Structural Insights into the Pseudomonas aeruginosa Type VI Virulence Effector Tse1 Bacteriolysis and Self-protection Mechanisms
2012
Crystallization and Preliminary X-Ray Diffraction Analysis of a Novel Mannose-Binding Lectin with Antiretroviral Properties from Polygonatum cyrtonema Hua
2008
Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose
2018 Nature
Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA
2013
Structural Mechanism Governing the Quaternary Organization of Monocot Mannose-binding Lectin Revealed by the Novel Monomeric Structure of an Orchid Lectin
2005
Structural basis of the ultrasensitive calcium indicator GCaMP6
2014
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
A bioorthogonal system reveals antitumour immune function of pyroptosis
2020 Nature
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
2020 Science