Citation Impact

Citing Papers

The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans
2012 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response
2007 Science
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
2002 StandoutScience
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Phosphoacetylation of histone H3 on c- fos - and c- jun -associated nucleosomes upon gene activation
2000
ER p18 regulates activation of ATF 6α during unfolded protein response
2019
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response
2006
Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
2019
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH
2010
Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival
2006
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Substrate Specificity of Rhomboid Intramembrane Proteases Is Governed by Helix-Breaking Residues in the Substrate Transmembrane Domain
2003
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
2001
Inflammation and metabolic disorders
2006 StandoutNature
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
2002 StandoutNature
A trip to the ER: coping with stress
2003
Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans
2005
Chromatin Modifications and Their Function
2007 Standout
γ-Secretase: proteasome of the membrane?
2004
A transgenic mouse model for monitoring endoplasmic reticulum stress
2003
ER stress and the unfolded protein response
2004
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Cleavage of the membrane‐bound transcription factor OASIS in response to endoplasmic reticulum stress
2006
Autophagy regulates lipid metabolism
2009 StandoutNature
Activation of Transcription through Histone H4 Acetylation by MOF, an Acetyltransferase Essential for Dosage Compensation in Drosophila
2000
The unfolded protein response in nutrient sensing and differentiation
2002
Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals
2009
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease
2004
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
The language of covalent histone modifications
2000 StandoutNature
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
Extra cytoplasmic function σ factor activation
2012
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
2006
ER stress, autophagy, and RNA viruses
2014
Regulated Intramembrane Proteolysis
2000
Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα
2005
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
2001 Standout
Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II
2004
Orchestrating the unfolded protein response in health and disease
2002
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
2005
The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis
2001
Coupling endoplasmic reticulum stress to the cell death program
2004
A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response
1999
Herp Is Dually Regulated by Both the Endoplasmic Reticulum Stress-specific Branch of the Unfolded Protein Response and a Branch That Is Shared with Other Cellular Stress Pathways
2004
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
2007
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Protein folding and misfolding
2003 StandoutNature
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
2019
Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response
2002
Endoplasmic reticulum stress triggers an acute proteasome‐dependent degradation of ATF6
2004
ER chaperone functions during normal and stress conditions
2004
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Roles of CHOP/GADD153 in endoplasmic reticulum stress
2003 Standout
Hepatitis C virus, ER stress, and oxidative stress
2005
ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress
2007
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
2003
Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells
1998 Nobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Ordered assembly of roX RNAs into MSL complexes on the dosage-compensated X chromosome in Drosophila
2000
Crystal structure of a rhomboid family intramembrane protease
2006 Nature
A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response
2003
Regulation of apoptosis by endoplasmic reticulum pathways
2003
Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
2006
IRE1-Independent Gain Control of the Unfolded Protein Response
2004
The role of the unfolded protein response in tumour development: friend or foe?
2004
The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi
2002
Implication of APP Secretases in Notch Signaling
2001
Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress
2003
ATF6 modulates SREBP2‐mediated lipogenesis
2004
Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifyingGolgi/post-Golgi compartments
2015
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
2004
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
2018
Underglycosylation of ATF6 as a Novel Sensing Mechanism for Activation of the Unfolded Protein Response
2004
Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development
2001
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
2004
B- and T-cell Development Both Involve Activity of the Unfolded Protein Response Pathway
2008
Amyloid Precursor Protein Processing in Sterol Regulatory Element-binding Protein Site 2 Protease-deficient Chinese Hamster Ovary Cells
1998
The Protein Kinase/Endoribonuclease IRE1α That Signals the Unfolded Protein Response Has a Luminal N-terminal Ligand-independent Dimerization Domain
2002
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
2019
Requirements for Signal Peptide Peptidase-Catalyzed Intramembrane Proteolysis
2002
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
2002
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
2002
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response
2004
Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction
1998
Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation
2004
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
2010
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Endoplasmic Reticulum Stress Signaling in Disease
2006
The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum
2004
Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response
2006
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
Transmembrane bZIP Transcription Factors in ER Stress Signaling and the Unfolded Protein Response
2007
How Transmembrane Proteins Sense Endoplasmic Reticulum Stress
2007
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
2007
The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control
2006
Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease
1999
Coping with Protein Quality Control Failure
2017
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
2006
Transient Cerebral Ischemia Activates Processing of xbp1 Messenger RNA Indicative of Endoplasmic Reticulum Stress
2003
Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis
2011
Intracellular Signaling by the Unfolded Protein Response
2006
Activation of Mammalian Unfolded Protein Response Is Compatible with the Quality Control System Operating in the Endoplasmic Reticulum
2004
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress
2018
Endoplasmic Reticulum Stress in Immunity
2014
The Action of Molecular Chaperones in the Early Secretory Pathway
2001
Histone Acetyltransferases
2001 Standout
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
1999 Nobel
Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans
2018 StandoutNobel
Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress
2010
Orchestrating the unfolded protein response in health and disease
2002
Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
1999
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
2005 Standout
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
2014
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
2002
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
2003 Standout
Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element
2006
Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes
1998
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
2001 Nobel
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
2001
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
2007
NOTCH ANDPRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Translating the Histone Code
2001 StandoutScience
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 StandoutScience
Transcriptional and Translational Control in the Mammalian Unfolded Protein Response
2002
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein
2011
A survival pathway forCaenorhabditis eleganswith a blocked unfolded protein response
2002
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Stable Binding of ATF6 to BiP in the Endoplasmic Reticulum Stress Response
2005
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
2001
BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer
2006
Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress
2006
Differential regulation of CENP-A and histone H3 phosphorylation in G2/M
2001
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
2003
ATF6α induces XBP1-independent expansion of the endoplasmic reticulum
2009
Molecular imprinting: perspectives and applications
2016 Standout
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by Site-2 protease
2000 Nobel

Works of Jin Ye being referenced

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
2018
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
2000
JIL-1
1999
Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs
1997 Nobel
A Boronate Affinity Sandwich Assay: An Appealing Alternative to Immunoassays for the Determination of Glycoproteins
2014
Jil-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (Msl) Dosage Compensation Complex
2000
Rankless by CCL
2026