Citation Impact
Citing Papers
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase
2001 Science
TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain
2002 StandoutNobel
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
2002
Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop
2010
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Substrate Specificity of Rhomboid Intramembrane Proteases Is Governed by Helix-Breaking Residues in the Substrate Transmembrane Domain
2003
mTOR Signaling in Growth Control and Disease
2012 Standout
Inflammation and metabolic disorders
2006 StandoutNature
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
2002 StandoutNature
Three-dimensional structure of human γ-secretase
2014 Nature
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
γ-Secretase: proteasome of the membrane?
2004
The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation
2001
Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases
2001
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides
2003
Hypomorphic Mutation in the Site-1 Protease Mbtps1 Endows Resistance to Persistent Viral Infection in a Cell-Specific Manner
2011 StandoutNobel
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles
2004 StandoutNobel
Cleavage of the membrane‐bound transcription factor OASIS in response to endoplasmic reticulum stress
2006
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
2015 Nobel
Novel Class of Polytopic Proteins with Domains Associated with Putative Protease Activity
2002
Mobilization of Processed, Membrane-Tethered SPT23 Transcription Factor by CDC48UFD1/NPL4, a Ubiquitin-Selective Chaperone
2001
Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating
2015 Nature
The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
2001
The changing landscape of atherosclerosis
2021 StandoutNature
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
2006
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
β‐Amyloid efflux mediated by p‐glycoprotein
2001
Neurotrophins and their receptors: A convergence point for many signalling pathways
2003 Standout
Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II
2004
Coupling endoplasmic reticulum stress to the cell death program
2004
Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing
2000
A common enzyme connects Notch signaling and Alzheimer's disease
2000
Human and mouse proteases: a comparative genomic approach
2003
The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner
2001
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide
2002
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Deletion of Presenilin 1 Hydrophilic Loop Sequence Leads to Impaired γ-Secretase Activity and Exacerbated Amyloid Pathology
2006
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
A Glimpse of Structural Biology through X-Ray Crystallography
2014
Crystal structure of a rhomboid family intramembrane protease
2006 Nature
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
2000
Distribution of an NMDA receptor:GFP fusion protein in sensory neurons is altered by a C-terminal construct
2001
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi
2002
Implication of APP Secretases in Notch Signaling
2001
Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein
2003
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Obesity and the Regulation of Energy Balance
2001 Standout
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
Notch Signaling: From the Outside In
2000
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
2004
Secretases as targets for the treatment of Alzheimer's disease: the prospects
2002
Requirements for Signal Peptide Peptidase-Catalyzed Intramembrane Proteolysis
2002
Processing of β-Amyloid Precursor-like Protein-1 and -2 by γ-Secretase Regulates Transcription
2002
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
2002
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
2000
Signaling by the Drosophila epidermal growth factor receptor pathway during development
2003
A Dominant Role for FE65 (APBB1) in Nuclear Signaling
2005
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
2001
The β‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?
2002
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer
2017
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Discovery of the cellular and molecular basis of cholesterol control
2013 StandoutNobel
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Activation of Mammalian Unfolded Protein Response Is Compatible with the Quality Control System Operating in the Endoplasmic Reticulum
2004
The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
2001
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes
2006
Oh no, Notch again!
2000
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
Presenilin-dependent γ-secretase activity modulates thymocyte development
2001
Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes
2001
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
2007 Nobel
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
The Conserved Npl4 Protein Complex Mediates Proteasome-dependent Membrane-bound Transcription Factor Activation
2001
Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element
2006
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid
2011
The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
2007
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 StandoutScience
Transcriptional and Translational Control in the Mammalian Unfolded Protein Response
2002
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease
2002 Science
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
2001
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress
2006
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ
2001
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by Site-2 protease
2000 Nobel
Works of Jin Y being referenced
Regulated Intramembrane Proteolysis
2000