Standout Papers
Citation Impact
Citing Papers
Lithium delays progression of amyotrophic lateral sclerosis
2008
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
2006 StandoutScience
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
1995
Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis
2008
The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
2003 Standout
Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial Membranes
1997
Noradrenergic locus coeruleus neurons: their distant connections and their relationship to neighboring (including cholinergic and GABAergic) neurons of the central gray and reticular formation
1991
Parkinson's disease
2021 Standout
Activity‐dependent and hormonal regulation of neurotrophin mRNA levels in brain–implications for neuronal plasticity
1994
Novelty seeking behavior in the rat is dependent upon the integrity of the noradrenergic system
1995
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons
1997
Cell-type Specific Targeting of the α2c-Adrenoceptor
2000 StandoutNobel
In vivo noradrenaline release evoked in the anteroventral thalamic nucleus by locus coeruleus activation: An electrochemical study
1993
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
Consensus guidelines for the design and implementation of clinical trials in ALS
1999
Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis
2006
Defects in enteric innervation and kidney development in mice lacking GDNF
1996 StandoutNature
Distribution of α2-adrenergic receptor subtype gene expression in rat brain
1994
Amyotrophic lateral sclerosis
2011 Standout
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study
2004
Design of phase II ALS clinical trials
2008
The management of motor neurone disease
2003
Managing patients with amyotrophic lateral sclerosis
2008
The neuroanatomical and neurochemical basis of conditioned fear
1999
The landscape of NeuroImage-ing research
2018
Hierarchical feature representation and multimodal fusion with deep learning for AD/MCI diagnosis
2014 Standout
Distinct cerebral lesions in sporadic and ‘D90A’ SOD1 ALS: studies with [11C]flumazenil PET
2005
Apoptosis and Its Role in Human Disease
1994
Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial
2006
Intracellular Signaling Pathways Activated by Neuropathic Factors
1996
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
2007
Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat
1990
Diagnostic investigation and multidisciplinary management in motor neuron disease
2005
Electrodiagnostic studies in amyotrophic lateral sclerosis and other motor neuron disorders
2000
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
1995 Nature
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
The Role of the Amygdala in Fear and Anxiety
1992 Standout
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Alzheimer's disease
2016 Standout
Subgenual prefrontal cortex abnormalities in mood disorders
1997 StandoutNature
Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma
2007 Standout
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
2000 StandoutNature
The induction of pain: an integrative review
1999
GDNF signalling through the Ret receptor tyrosine kinase
1996 StandoutNature
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
2014
Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence
2009
Facilitation of learning consecutive to electrical stimulation of the locus coeruleus: cognitive alteration or stress-reduction?
1991
Responses of primate locus coeruleus neurons to simple and complex sensory stimuli
1988
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
2007 Standout
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin
1989 Standout
Effects of Angiotensin II on [3H]Noradrenaline Release and Phosphatidylinositol Hydrolysis in the Parietal Cortex and Locus Coeruleus of the Rat
1987
Decision making, the P3, and the locus coeruleus--norepinephrine system.
2005
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
2005 StandoutNature
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
1997
Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?
1990
Phasic activation of the locus coeruleus enhances responses of primary sensory cortical neurons to peripheral receptive field stimulation
1998
Role of locus coeruleus in attention and behavioral flexibility
1999
Abnormalities in cortical and peripheral excitability in flail arm variant amyotrophic lateral sclerosis
2007
Renal agenesis and the absence of enteric neurons in mice lacking GDNF
1996 StandoutNature
Three soccer playing friends with simultaneous amyotrophic lateral sclerosis
2007
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Neuroanatomical Hypothesis of Panic Disorder, Revised
2000
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala
1994 StandoutNature
Vagus nerve stimulation therapy for partial-onset seizures
1998 Standout
Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal.
1980
Noradrenergic modulation of the masseteric reflex in behaving cats. I. Pharmacological studies
1990
On the potassium conductance increased by opioids in rat locus coeruleus neurones.
1985
Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.
1995
Evidence for self- and neighbor-mediated postactivation inhibition of locus coeruleus neurons
1986
Activation of lateral geniculate neurons by norepinephrine: Mediation by an α-adrenergic receptor
1980
Effects of sleep and arousal on the processing of visual information in the cat
1981 StandoutNatureNobel
Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
1981
Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat
1998
Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area
1986
Aminergic neurons: State control and plasticity in three model systems
1981
Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies
1977
Unit-activity in the central amygdalar nucleus of rats in response to immobilization—stress
1983
Non‐invasive ventilation in ALS: current practice and future role
2004
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
1990 StandoutScience
5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.
1989 StandoutNobel
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
1999 StandoutScience
Brain noradrenergic neurons in the locus coeruleus: inhibition by blood volume load through vagal afferents
1979
Membrane properties of rat locus coeruleus neurones
1984
Ultrastructural evidence for prominent postsynaptic localization of ?2C-adrenergic receptors in catecholaminergic dendrites in the rat nucleus locus coeruleus
1998
Beta-Adrenergic-Receptor Localization by Light Microscopic Autoradiography
1980 Science
Advances in targeted therapeutic agents
2010
Effect of adrenaline synthesis inhibition on brain noradrenaline neurons in locus coeruleus
1981
When Fear Is Near: Threat Imminence Elicits Prefrontal-Periaqueductal Gray Shifts in Humans
2007 StandoutScienceNobel
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
The Role of Locus Coeruleus in the Regulation of Cognitive Performance
1999 Science
Biological Bases of Childhood Shyness
1988 StandoutScience
Neurobiological mechanisms in human anxiety evidence supporting central noradrenergic hyperactivity
1983
Idazoxan, an α-2 antagonist, facilitates memory retrieval in the rat
1989
Synaptic Activity and the Construction of Cortical Circuits
1996 StandoutScience
Reduced fear expression after lesions of the ventral hippocampus
2002 StandoutNobel
A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis
2008
The natural history of primary lateral sclerosis
2006
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
Interaction of Convulsive Ligands with Benzodiazepine Receptors
1982 StandoutScience
Biology and Clinical Development of Vascular Endothelial Growth Factor–Targeted Therapy in Renal Cell Carcinoma
2004
Single unit activity of locus coeruleus neurons in the freely moving cat
1986
Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides
1977
Afferent projections to the self-stimulation regions of the dorsal pons, including the locus coeruleus, in the rat as demonstrated by the horseradish peroxidase technique
1979
Neurotrophins and Neuronal Plasticity
1995 StandoutScience
The neuropsychology and neuropharmacology of the dorsal ascending noradrenergic bundle—a review
1980
Cellular and Molecular Mechanisms of Drug Dependence
1988 StandoutScience
Localization of neurones projecting to the hypothalamic paraventricular nucleus area of the rat: A horseradish peroxidase study
1981
Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
1984
Noradrenaline‐mediated synaptic inhibition in rat locus coeruleus neurones.
1983
The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network
1986 Science
Multiple receptors for dopamine
1979 StandoutNature
Iontophoresis of neurotensin in the area of the locus coeruleus
1978
Inhibitory influence of frontal cortex on locus coeruleus neurons.
1995
Genetic contributions to generalized arousal of brain and behavior
2003 StandoutNobel
The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function
1988 StandoutScience
The fine structural organization of the locus coeruleus in the rat with reference to noradrenaline contents
1979
Benzodiazepines: Potentiation of a GABA inhibitory response in the dorsal raphe nucleus
1978
Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain.
1983 StandoutNobel
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
1997 Standout
Predicting research trends with semantic and neural networks with an application in quantum physics
2020 StandoutNobel
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine
1978 Nature
The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat
1982
Intrinsic regulation of locus coeruleus neurons: electrophysiological evidence indicating a predominant role for autoinhibition
1984
Characterization of α2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones
1985
Subtotal destruction of central noradrenergic projections increases the firing rate of locus coeruleus cells
1983
Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxidase study in the rat
1979
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
Subcortical afferent connections of the amygdala in the monkey
1980
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Cellular Organization of Locus Coeruleus in the Rat as Studied by Golgi Method
1978
Noradrenergic responses in rat hippocampus: Evidence for mediation by α and β receptors in the in vitro slice
1981
Central Noradrenergic Pathways for the Integration of Hypothalamic Neuroendocrine and Autonomic Responses
1981 Science
Adrenoceptors on central neurones: Microelectrophoretic studies
1979
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
2004
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Emerging Pharmacotherapies for Diabetic Macular Edema
2012
Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit
1979
Impulse conduction properties of noradrenergic locus coeruleus axons projecting to monkey cerebrocortex
1985
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
1983 Standout
Low doses of ethanol disrupt sensory responses of brain noradrenergic neurones
1982 Nature
Locus coerules neurons have axons that branch to the forebrain and cerebellum
1981
Effects of ?-adrenoceptor antagonists on the firing rate of noradrenergic neurones in the locus coeruleus of the rat
1981
Electrophysiological and biochemical responses of noradrenergic neurons to a non-amphetamine CNS stimulant
1979
Serotonin selectively attenuates glutamate-evoked activation of noradrenergic locus coeruleus neurons
1991
AN INTEGRATIVE THEORY OF LOCUS COERULEUS-NOREPINEPHRINE FUNCTION: Adaptive Gain and Optimal Performance
2005 Standout
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Neurotrophic factors: from molecule to man
1994
Benzodiazepines attenuate single unit activity in the locus coeruleus
1980
Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey
1984
Assessment of disease progression in motor neuron disease
2005
A synthetic peptide as an antagonist of substance P
1981 Nature
A study of inputs to antidromically identified neurons of the locus coeruleus
1977
Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action on responses to noxious stimuli.
1979
Hypercapnia and hypoxia: Chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves
1981
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats
1978
Works of Jesse M. Cedarbaum being referenced
Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054
2019
Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat
1998
An exploratory study of the safety, tolerability and bioactivity of a single intravitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema
2009
The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function
1999 Standout
The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
1994
Disease status and use of ventilatory support by ALS patients
2001
The Therapeutic Potential of Neurotrophic Factors in the Treatment of Parkinson's Disease
1993
Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials
1997
Regional changes of ciliary neurotrophic factor and nerve growth factor levels in post mortem spinal cord and cerebral cortex from patients with motor disease
1995
Effects of brain‐derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
1995
A retrospective study of percutaneous endoscopic gastrostomy in ALS patients during the BDNF and CNTF trials
1999
Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF
1994 Science
Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane
1976
Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats
1977
Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique
1978
Phase I and pharmacokinetic study of VEGF Trap administered subcutaneously (sc) to patients (pts) with advanced solid malignancies
2004
Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014
2015
Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons
1977
Mild cognitive impairment: Disparity of incidence and prevalence estimates
2012
A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
2011
Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization
1977
Phase 1 Study of Aflibercept Administered Subcutaneously to Patients with Advanced Solid Tumors
2009
Prognostic indicators of survival in ALS
1998
Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism
1978
Mitochondrial dysfunction and spinocerebellar degenerations
1986