Standout Papers
Citation Impact
Citing Papers
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer
2005 StandoutNobel
Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm
1997
Nanog Is the Gateway to the Pluripotent Ground State
2009 StandoutNobel
Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain
1997
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
1998
Chimeras and mosaics in mouse mutant analysis
1998
Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex
2002
Expression of theSox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction
1997
Expression of a candidate sex-determining gene during mouse testis differentiation
1990 Nature
Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis
1998
HMG domain proteins: architectural elements in the assembly of nucleoprotein structures
1994
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue
1997
Sox‐4 facilitates thymocyte differentiation
1997
Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development
1995
Male development of chromosomally female mice transgenic for Sry
1991 StandoutNature
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
1999
SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the Adult
2004
Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9
1994
Sexual differentiation in fission yeast
1990
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Multipotent cell lineages in early mouse development depend on SOX2 function
2003 Standout
Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal
1993
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
1998
Sequence and expression of Sox-18 encoding a new HMG-box transcription factor
1995
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
1994 StandoutNature
It's not just baby's babble/Babel: Recent progress in understanding the language of early mammalian development: A minireview
1999
Hedgehog signalling in the mouse requires intraflagellar transport proteins
2003 StandoutNature
Assignment of an autosomal sex reversa– locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3–q25.1
1993
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
2007
Sox genes find their feet
1997
Pairing SOX off: with partners in the regulation of embryonic development
2000
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Notch signaling regulates left–right asymmetry determination by inducingNodalexpression
2003
Expression of a linear Sry transcript in the mouse genital ridge
1995
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Origin and diversity of the Sox transcription factor gene family: genome-wide analysis in Fugu rubripes
2004 Nobel
The dpy-30 gene encodes an essential component of the Caenorhabditis elegans dosage compensation machinery.
1994
TheSry-related HMG box-containing geneSox6is expressed in the adult testis and developing nervous system of the mouse
1995
XLS13A and XLS13B: SRY-related genes of Xenopus laevis
1997
Muscle Differentiation Is Antagonized by SOX15, a New Member of the SOX Protein Family
2000
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
1995
Sinistral Snails and Gentlemen Scientists
2005 StandoutNobel
From fertilization to gastrulation: axis formation in the mouse embryo
2001
Isolation and expression of a human SRY-related cDNA, hSOX20
1998
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
High expression of the HMG box factor Sox-13 in arterial walls during embryonic development
1998
Mechanisms of complex transcriptional regulation: implications for brain development
1991
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Differential Roles for Sox15 and Sox2 in Transcriptional Control in Mouse Embryonic Stem Cells
2005 StandoutNobel
Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4
1996 Nature
Gene function in mouse embryogenesis: get set for gastrulation
2007
Left–right asymmetry in embryonic development: a comprehensive review
2004
SRY-related genes in Xenopus oocytes
1996
The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box
1998
Cloning and characterization ofXenopus laevis xSox7 cDNA
1996
Ancestry and diversity of the HMG box superfamily
1993
MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos
1996 StandoutNobel
Functional Analysis of Sox10 Mutations Found in Human Waardenburg-Hirschsprung Patients
1998
SRY AND SEX DETERMINATION IN MAMMALS
1993
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse
1997
Modulation of the Activity of Multiple Transcriptional Activation Domains by the DNA Binding Domains Mediates the Synergistic Action of Sox2 and Oct-3 on the Fibroblast Growth Factor-4Enhancer
2000
Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
2011
Nodal signaling and the evolution of deuterostome gastrulation
2005
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
A human XY female with a frame shift mutation in the candidate testis-determining gene SRY
1990 Nature
Early aspects of Caenorhabditis elegans sex determination and dosage compensation are regulated by a zinc-finger protein
1991 Nature
Cloning and characterization of mouse mSox13 cDN
1998
Seven new members of theSoxgene family expressed during mouse development
1993
cSox21 exhibits a complex and dynamic pattern of transcription during embryonic development of the chick central nervous system
1997
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
1996 Standout
Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue
1997
DNA binding and bending properties of the postmeiotically expressed Sry-related protein Sox-5
1994
Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched
2002
DNA-binding properties of the product of the testis-determining gene and a related protein
1991 Nature
Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
1999
The Type II Activin Receptors Are Essential for Egg Cylinder Growth, Gastrulation, and Rostral Head Development in Mice
1999
Nodal Antagonists in the Anterior Visceral Endoderm Prevent the Formation of Multiple Primitive Streaks
2002
Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
2002
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
IRE-ABP (Insulin Response Element-A Binding Protein), an SRY-Like Protein, Inhibits C/EBPα (CCAAT/Enhancer-Binding Proteinα )-Stimulated Expression of the Sex-Specific Cytochrome P450 2C12 Gene
1998
Genetic evidence equating SRY and the testis-determining factor
1990 Nature
Rainbow trout Sox24, a novel member of the Sox family, is a transcriptional regulator during oogenesis
1998
Derivation of pluripotent epiblast stem cells from mammalian embryos
2007 StandoutNature
Solution Structure of the Sequence-specific HMG Box of the Lymphocyte Transcriptional Activator Sox-4
1995
Cloning and expression of Xenopus laevis xSox12 cDNA
1996
Dax1 antagonizes Sry action in mammalian sex determination
1998 Nature
SoxD
1998
A Fresh Look at iPS Cells
2009 StandoutNobel
Genomic Rearrangements and Gene Copy-Number Alterations as a Cause of Nervous System Disorders
2006
New cell lines from mouse epiblast share defining features with human embryonic stem cells
2007 StandoutNature
Expression of the SOX10 gene during human development
1998
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice
1998
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
1996
The basics of epithelial-mesenchymal transition
2009 Standout
pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos
1995
Rainbow trout SOX9: cDNA cloning, gene structure and expression
1997
Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
2000
Sox15, a novel member of the murineSoxfamily of HMG box transcription factors
1993
SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter
2001
Two closely‐related left‐right asymmetrically expressed genes, lefty‐1 and lefty‐2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos
1997
A conserved family of genes related to the testis determining gene,SRY
1992
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
The SOX10 / Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor
1998
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
1990 StandoutNature
Mouse gastrulation: the formation of a mammalian body plan
1997
From head to toes: the multiple facets of Sox proteins
1999 Standout
An SRY Mutation Causing Human Sex Reversal Resolves a General Mechanism of Structure-Specific DNA Recognition: Application to the Four-Way DNA Junction
1995
Nucleotide sequence of mouse Sry gene is different between Y chromosomes originating from Mus musculus musculus and Mus musculus domesticus
1992
Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
2007
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo
1998 Nature
Anterior patterning in mouse
1998
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Feedback control of sex determination by dosage compensation revealed through Caenorhabditis elegans sdc-3 mutations.
1993
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
2009
WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour
1991 Nature
Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice.
2006
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.
1990
Expression of Sry, the mouse sex determining gene
1995
Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae.
1995 StandoutNobel
Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia
1998
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Sex-reversing mutations affect the architecture of SRY-DNA complexes.
1994
A role for SOX1 in neural determination
1998
SRY, like HMG1, recognizes sharp angles in DNA.
1992
Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene
1998
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Synergistic Activation of the Fibroblast Growth Factor 4 Enhancer by Sox2 and Oct-3 Depends on Protein-Protein Interactions Facilitated by a Specific Spatial Arrangement of Factor Binding Sites
1997
An SRY-related sequence on the marsupial X chromosome:implications for the evolution of the mammalian testis-determininggene.
1994
Sox2 regulatory sequences direct expression of a β-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells
2000
A ZFY-negative 46,XX true hermaphrodite is positive for the Y pseudoautosomal boundary
1990
Nuclear localization of the testis determining gene product SRY.
1995
SOX Genes: Architects of Development
1996
Evidence for differential and redundant function of the Sox genesDichaeteandSoxNduring CNS development inDrosophila
2002
An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.
1992
Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators
2002
XY follicle cells in the ovaries of XO/XY and XO/XY/XYY mosaic mice
1991
The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation
1996
Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis.
1996
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
1997
Pivotal roles for eomesodermin during axis formation,epithelium-to-mesenchyme transition and endoderm specification in the mouse
2008
Pten is essential for embryonic development and tumour suppression
1998 Standout
Sox10, a Novel Transcriptional Modulator in Glial Cells
1998 Standout
A General Mechanism for Network-Dosage Compensation in Gene Circuits
2010 StandoutScienceNobel
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.
1993 StandoutNobel
Regulation of gene expression by oxygen in Saccharomyces cerevisiae
1992
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Neural Science
2000 StandoutNobel
Sry is a transcriptional activator.
1994
Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction
1998
Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm
2000
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
2012 StandoutNobel
XY female mice resulting from a heritable mutation in the primary testis determining gene, Tdy
1990
Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2
1997
Sex Determination and Dosage Compensation: Lessons from Flies and Worms
1994 Science
Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning
2006
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.
1992
DNA Binding Activity of Recombinant SRY from Normal Males and XY Females
1992 Science
A Gene That Is Related to SRY and Is Expressed in the Testes Encodes a Leucine Zipper-Containing Protein
1995
Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins
1991 Science
Genetic control of blood pressure and the angiotensinogen locus.
1995 StandoutNobel
A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination
2002
Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak
1997
The murine Sox-4 protein is encoded on a single exon
1993
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Analysis of xbx genes in C. elegans
2005 StandoutNobel
Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.
1993
HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.
1994 StandoutNobel
Mutation of the Sry-related Sox10 gene in Dominant megacolon , a mouse model for human Hirschsprung disease
1998
The chromosomal distribution of mouse odorant receptor genes.
1996 StandoutNobel
A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects
1993 Science
The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination
2000
Cilia and Hedgehog responsiveness in the mouse
2005
Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID.
1993
The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline
1998
A male-specific role for SOX9 in vertebrate sex determination
1996
Involvement of SOX proteins in lens-specific activation of crystallin genes.
1995
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
1995
Works of Jérôme Collignon being referenced
Relationship between asymmetric nodal expression and the direction of embryonic turning
1996 Nature
Zfy gene expression patterns are not compatible with a primary role in mouse sex determination
1989 Nature
The cDNA sequence and chromosomal location of the human SOX2 gene
1994
Characterization and mapping of the human SOX4 gene
1993
Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo
2006
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
1990 StandoutNature
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
1997
Normal structure and expression of Zfy genes in XY female mice mutant in Tdy
1990
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
1996
Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction
1998
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
1997
The Transcription Factor RFX3 Directs Nodal Cilium Development and Left-Right Asymmetry Specification
2004
Developmental abnormalities of NT mouse embryos appear early after implantation
2006
SOX3 is an X-linked gene related to SRY
1993