Jennifer Otten

Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY‐142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Microfluidic organs-on-chips

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Iron Catalysis in Organic Synthesis

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

Oxadiazoles in Medicinal Chemistry

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

Well-Defined Iron Catalysts for the Acceptorless Reversible Dehydrogenation-Hydrogenation of Alcohols and Ketones

Advances in the Baylis–Hillman reaction-assisted synthesis of cyclic frameworks

Synthesis of substituted 3-methylene-2-pyridones from Baylis–Hillman derivatives and its application for the generation of 2-pyridone substituted spiroisoxazolines

Applications of Fluorine in Medicinal Chemistry

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Rapid and Selective Catalytic Oxidation of Secondary Alcohols at Room Temperature by Using (N‐Heterocyclic Carbene)–Ni⁰ Systems

Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2

Potent and Selective Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors. 1. 4-(4-Bromo-2-fluorophenylamino)-1- methylpyridin-2(1H)-ones