Standout Papers
Citation Impact
Citing Papers
TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization
2010
Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death
1995 Science
The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry
1997
Effects of cisplatin and amphotericin B on DNA adduct formation and toxicity in malignant glioma and normal tissues in rat
1997
Overexpression of the Bcl-2 Protein Increases the Half-life of p21Bax
1995
Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis
2007
A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members
1997
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction ofbcl-2 Gene Expression
1994
The genetic regulation of apoptosis
1995
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
1995
Mitochondrial control of apoptosis
1997
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Induction of apoptosis by the Bcl-2 homologue Bak
1995 Nature
BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development
1996
Bcl-2 regulates activation of apoptotic proteases in a cell-free system
1996
Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak
1995 Nature
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 Standout
The Hallmarks of Cancer
2000 Standout
Morphologic and biochemical hallmarks of apoptosis
2000
An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor
1996 StandoutNobel
Programmed cell death in Caenorhabditis elegans
1994 StandoutNobel
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
1993 Standout
Bcl-2 Family Proteins: Strategies for Overcoming Chemoresistance in Cancer
1997
Bcl-2 family proteins
1998
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
1997 Standout
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
The versatility and universality of calcium signalling
2000 Standout
Investigations of Antisense Oligonucleotides Targeted Againstbcl-2RNAs
1993
Cellular and molecular determinants of cisplatin resistance
1998
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
The Mitochondrial F0F1-ATPase Proton Pump Is Required for Function of the Proapoptotic Protein Bax in Yeast and Mammalian Cells
1998
The proto-oncogene Bcl-2 and its role in regulating apoptosis
1997 Standout
Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain
1999
Molecular Ordering of the Cell Death Pathway
1996
Biochemical properties and biological effects of p53
1995
Structure-Function Analysis of Bcl-2 Protein
1995
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Apoptosis induced in advanced CD8F1-murine mammary tumors by the combination of PALA, MMPR and 6AN precedes tumor regression and is preceded by ATP depletion
1997
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
1993
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Regulation of Lymphocyte Survival by the BCL-2 Gene Family
1995
Identification of a novel regulatory domain in Bcl-xL and Bcl-2
1997
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast
1998
Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria
1994
Recombinant Mouse Bcl-2(1-203)
1996
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Dimerization Properties of Human BAD
1997
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The mitochondrial permeability transition
1995 Standout
Neural apoptosis
1995
Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
1995 Nature
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2
1996
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Cancer-related inflammation
2008 StandoutNature
Programmed cell death and Bcl-2 protection in very low oxygen
1995 Nature
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
1998 Standout
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein
1992
Recent insights into platinum drug resistance in cancer
1998
Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2
1997 Nature
Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis
1998
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
The B7 and CD28 receptor families
1994
Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2
1994 StandoutNatureNobel
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
1998
Apoptosis in the Failing Human Heart
1997 Standout
Direct Interaction of the Mitochondrial Membrane Protein Carnitine Palmitoyltransferase I with Bcl-2
1997 StandoutNobel
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation.
1996
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
1997
Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance
2003 Standout
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.
1995
The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling
1998
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline
1999 StandoutNobel
Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation.
1995
Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart
2000
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX
1998
Structure of Bcl-x L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis
1997 Science
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
1997 StandoutScience
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.
1993
Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells.
1994
Function of Ras as a molecular switch in signal transduction.
1992
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.
1994
BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway
1996
Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.
1994
T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.
1996
Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.
1995
Constitutive expression of the machinery for programmed cell death.
1996
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.
1996
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.
1994
A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.
1995
Neural Science
2000 StandoutNobel
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.
1996
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
1995 Standout
Bax directly induces release of cytochrome c from isolated mitochondria
1998
Molecular thanatopsis: a discourse on the BCL2 family and cell death
1996
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Structure, Recognition, and Processing of Cisplatin−DNA Adducts
1999 Standout
Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.
1997
Transformations and recognition of platinum-DNA adducts: recent developments
1997
Functional Dissection of the Human Bcl2 Protein: Sequence Requirements for Inhibition of Apoptosis
1996
Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.
1997
Mitochondria and Apoptosis
1998 StandoutScience
IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.
1994
Bcl-2 does not require Raf kinase activity for its death-protective function
1997
Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases
1995 StandoutScience
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.
1996
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
1993
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.
1994
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
1996
Identification of Genes That Mediate Sensitivity to Cisplatin
2001
Channel formation by antiapoptotic protein Bcl-2
1997
Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice
1999
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus
1994
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development
1996
Structure-Function Comparisons of the Proapoptotic Protein Bax in Yeast and Mammalian Cells
1996
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells.
1995
baxDeficiency Prevents the Increased Cell Death of Immature Neurons inbcl-x-Deficient Mice
1997
β-Adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy
1998
Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice
2001
Apoptosis by a cytosolic extract from Fas-activated cells.
1995
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Disruption of epithelial cell-matrix interactions induces apoptosis
1994 Standout
Genotoxic exposure is associated with alterations in glucose uptake and metabolism.
2002
Works of JC Reed being referenced
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.
1994
Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line.
1994
Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines
1992
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
1993
Upregulation of bax protein levels in neurons following cerebral ischemia
1995
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
1993
Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases LCK and LYN
1992
Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.
1996
A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation
1996
Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas
1992
bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
1993
Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein.
1995
Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells.
1993
Bcl-2 and the regulation of programmed cell death
1994 Standout