Standout Papers
Citation Impact
Citing Papers
Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture
2004
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
2004 StandoutScience
Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
2004 StandoutScience
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
2003
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
2008 StandoutScience
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
2017
Use of a drug‐resistant mutant of stress‐activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580
1999
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
BIRB796 Inhibits All p38 MAPK Isoforms in Vitro and in Vivo
2005
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
1999 StandoutNature
mTOR Signaling in Growth Control and Disease
2012 Standout
Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α
1998
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo
1995 Standout
The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase‐1β (Rsk‐2) and p70 S6 kinase
1997
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
1997
Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase
1996
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
1999 StandoutNature
High Intensity ERK Signal Mediates Hepatocyte Growth Factor-induced Proliferation Inhibition of the Human Hepatocellular Carcinoma Cell Line HepG2
2001
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Feedback control of the protein kinase TAK1 by SAPK2a/p38
2003
Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket
1998
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
2011
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 StandoutNature
Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation
1998
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo
1999
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
1997
Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059
1998
Regulation and function of the JNK subgroup of MAP kinases
1997
Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors
2002
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Neuroligin 1: A splice site-specific ligand for β-neurexins
1995 StandoutNobel
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
1997
Protein kinases — the major drug targets of the twenty-first century?
2002 Standout
A pancreatic islet-specific microRNA regulates insulin secretion
2004 StandoutNature
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
1998
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB
1998
Osmolyte Strategy in Human Monocytes and Macrophages: Involvement of p38MAPKin Hyperosmotic Induction of Betaine and Myoinositol Transporters
1998
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Structural basis of inhibitor selectivity in MAP kinases
1998
The role of senescent cells in ageing
2014 StandoutNature
The Pyridinyl Imidazole Inhibitor SB203580 Blocks Phosphoinositide-dependent Protein Kinase Activity, Protein Kinase B Phosphorylation, and Retinoblastoma Hyperphosphorylation in Interleukin-2-stimulated T Cells Independently of p38 Mitogen-activated Protein Kinase
2000
1 p38 MAP Kinase: Molecular Target for the Inhibition of Pro-inflammatory Cytokines
2001
Specificity and mechanism of action of some commonly used protein kinase inhibitors
2000 Standout
The Hallmarks of Aging
2013 Standout
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
2002 StandoutNature
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
The development and therapeutic potential of protein kinase inhibitors
1999
Interleukin-1β-induced Rat Pancreatic Islet Nitric Oxide Synthesis Requires Both the p38 and Extracellular Signal-regulated Kinase 1/2 Mitogen-activated Protein Kinases
1998
Pathogen Recognition and Innate Immunity
2006 Standout
p38 and a p38-Interacting Protein Are Critical for Downregulation of E-Cadherin during Mouse Gastrulation
2006
Jun N-Terminal Kinase in Rheumatoid Arthritis
1999
Transcription factors: a new frontier for drug discovery
1996
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
Mechanism of activation of protein kinase B by insulin and IGF-1.
1996 Standout
Vacuolar ion channel of the yeast, Saccharomyces cerevisiae.
1987 StandoutNobel
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
2003
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.
1996
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation
1998
Death Receptors: Signaling and Modulation
1998 StandoutScience
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide
2007
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
2000 StandoutScience
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
1998 StandoutScience
The specificities of protein kinase inhibitors: an update
2003 Standout
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
1997 Science
A Biochemical Guide to Yeast Adhesins: Glycoproteins for Social and Antisocial Occasions
2007
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Printing Proteins as Microarrays for High-Throughput Function Determination
2000 StandoutScience
Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression
1998
The selectivity of protein kinase inhibitors: a further update
2007 Standout
The sequence of 967 amino acids at the carboxyl‐end of rat thyroglobulin
1985
The search for physiological substrates of MAP and SAP kinases in mammalian cells
1997
Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors
1997
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
1999 Standout
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
1997 StandoutScience
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.
1995
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
1998
Lamin B1 loss is a senescence-associated biomarker
2012
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Essential Role of p38α MAP Kinase in Placental but Not Embryonic Cardiovascular Development
2000
Role of Mitogen-Activated Protein Kinase Cascades in Mediating Lipopolysaccharide-Stimulated Induction of Cyclooxygenase-2 and IL-1β in RAW264 Macrophages
2000
Works of J.B. Rouse being referenced
Thyroglobulin structure-function. The amino acid sequence surrounding thyroxine.
1983
The fibronectin adhesin of Candida albicans
1994
The isolation of identical thyroxine containing amino acid sequences from bovine, ovine and porcine thyroglobulins
1984
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1
1995 Standout