Standout Papers
- TRPM8 Is Required for Cold Sensation in Mice (2007)
- Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels (2010)
- Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia (2015)
- LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength (2016)
- TRPV1 Is Activated by Both Acidic and Basic pH (2009)
- Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents (2012)
- Piezo proteins are pore-forming subunits of mechanically activated channels (2012)
- Piezo2 is the major transducer of mechanical forces for touch sensation in mice (2014)
- High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol (2006)
- Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014)
- Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression (2011)
- Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis (2013)
- Chemical activation of the mechanotransduction channel Piezo1 (2015)
- SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel (2014)
- Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels (2013)
- Correction: Corrigendum: Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels (2013)
- Piezo1 ion channel pore properties are dictated by C-terminal region (2015)
Citation Impact
Citing Papers
TRPA1 acts as a cold sensor in vitro and in vivo
2009
Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
2012
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
2019
The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels
2013
Structure of the cold- and menthol-sensing ion channel TRPM8
2017 Science
A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans
2020
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
2014
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
2015
Lymph flow regulates collecting lymphatic vessel maturation in vivo
2015
Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces
2016
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Negatively Charged Amino Acids Near and in Transient Receptor Potential (TRP) Domain of TRPM4 Channel Are One Determinant of Its Ca2+ Sensitivity
2014
Mechanotransduction in the muscle spindle
2014
A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
2018
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
2016
PIEZO2 is required for mechanotransduction in human stem cell–derived touch receptors
2014
Localized force application reveals mechanically sensitive domains of Piezo1
2016
The Role of the N Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization
2007
Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters
2017
Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels
2017
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
2018
Evolutionary conservation and changes in insect TRP channels
2009
Piezo1 Channels Are Inherently Mechanosensitive
2016 StandoutNobel
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
2015
Nociceptors: a phylogenetic view
2009
Functional Role for Piezo1 in Stretch-evoked Ca2+ Influx and ATP Release in Urothelial Cell Cultures
2014
Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons
2015
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
2016
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
The Primary cilium calcium channels and their role in flow sensing
2014
Mechanical stress activates NMDA receptors in the absence of agonists
2017
The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration
2019 StandoutNobel
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct β Sandwich Fold
2014
Molecular force transduction by ion channels – diversity and unifying principles
2012
Piezo1-dependent regulation of urinary osmolarity
2016
Mechano-Gated Ion Channels in Sensory Systems
2013
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Mechanisms of sensory transduction in the skin
2007 Nature
A Role of the Transient Receptor Potential Domain of Vanilloid Receptor I in Channel Gating
2007
Stressed podocytes—mechanical forces, sensors, signaling and response
2017
TRPM8 Mechanism of Cold Allodynia after Chronic Nerve Injury
2007
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis
2015
Quantifying and Modeling the Temperature-Dependent Gating of TRP Channels
2012
Requirement of a Soluble Intracellular Factor for Activation of Transient Receptor Potential A1 by Pungent Chemicals: Role of Inorganic Polyphosphates
2007
Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses
2014
Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
2016 StandoutNobel
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
2019 Nature
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
2010
Phenotyping sensory nerve endings in vitro in the mouse
2009
More than cool: Promiscuous relationships of menthol and other sensory compounds
2006 StandoutNobel
piezo2bRegulates Vertebrate Light Touch Response
2013
Pore region of TRPV3 ion channel is specifically required for heat activation
2008 StandoutNobel
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function
2016
Intact Aδ-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats
2008
Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons
2015
Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function
2008 StandoutNobel
Biallelic Loss of Proprioception-Related PIEZO2 Causes Muscular Atrophy with Perinatal Respiratory Distress, Arthrogryposis, and Scoliosis
2016
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Shear stress-induced Ca2+ mobilization in MDCK cells is ATP dependent, no matter the primary cilium
2013
The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors
2015
An Ion Channel Essential for Sensing Chemical Damage
2007 StandoutNobel
The Purified Mechanosensitive Channel TREK-1 Is Directly Sensitive to Membrane Tension
2013
Structure–functional intimacies of transient receptor potential channels
2009
Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain
2013
Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels
2015
Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
2009 StandoutNobel
Targeting TRP channels for pain relief
2013
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
2012 Nature
Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections
2008 StandoutNobel
Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
2014
Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels
2008 StandoutNobel
Sensory mechanotransduction at membrane-matrix interfaces
2014
TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology
2012
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
2007
The Role of PIEZO2 in Human Mechanosensation
2016
Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels
2009
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs
2007 StandoutNobel
Protonation of the Human PIEZO1 Ion Channel Stabilizes Inactivation
2015
TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells
2014
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
2008
Phosphoinositide Regulation of TRP Channels
2014
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Mechanically Activated Ion Channels
2015 StandoutNobel
Piezos thrive under pressure: mechanically activated ion channels in health and disease
2017 StandoutNobel
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
2011
Piezo2 is the principal mechanotransduction channel for proprioception
2015 StandoutNobel
TRPA1 antagonists as potential analgesic drugs
2011
Vagal Sensory Neuron Subtypes that Differentially Control Breathing
2015
Thermo-TRP Channels: Biophysics of Polymodal Receptors
2010
Distinct Roles of TRP Channels in Auditory Transduction and Amplification in Drosophila
2013
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
DEG/ENaC but Not TRP Channels Are the Major Mechanoelectrical Transduction Channels in a C. elegans Nociceptor
2011
Mechanical stretch triggers rapid epithelial cell division through Piezo1
2017 Nature
Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel
2015
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
2015
Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1
2007
The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception
2009
TRPA1 Contributes to Cold Hypersensitivity
2010 StandoutNobel
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Diversity in the Neural Circuitry of Cold Sensing Revealed by Genetic Axonal Labeling of Transient Receptor Potential Melastatin 8 Neurons
2007
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
2018
Mechanosensory molecules and circuits in C. elegans
2014
Transient Receptor Potential Channels in Sensory Neurons Are Targets of the Antimycotic Agent Clotrimazole
2008
Integrating the active process of hair cells with cochlear function
2014
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
TRPV1‐lineage neurons are required for thermal sensation
2010
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels
2016
ThermoTRP channels as modular proteins with allosteric gating
2007
Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain
2006
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation
2012 Nature
Transient receptor potential V2 expressed in sensory neurons is activated by probenecid
2007
Recessive PIEZO2 stop mutation causes distal arthrogryposis with distal muscle weakness, scoliosis and proprioception defects
2016
Human PIEZO1: Removing Inactivation
2013
Direct recording and molecular identification of the calcium channel of primary cilia
2013 Nature
Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels
2016
Piezo1 plays a role in erythrocyte volume homeostasis
2013
TRPA1 Channels Mediate Cold Temperature Sensing in Mammalian Vagal Sensory Neurons: Pharmacological and Genetic Evidence
2008
Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons
2016
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Gating the mechanical channel Piezo1
2012
Structure and mechanogating mechanism of the Piezo1 channel
2018 Nature
Mechanosensing is critical for axon growth in the developing brain
2016
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
Mammalian touch catches up
2015
Activation Properties of Heterologously Expressed Mammalian TRPV2
2007
TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells
2012
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison
2018
A role for Piezo2 in EPAC1-dependent mechanical allodynia
2013
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
2010 StandoutNobel
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six
2014 StandoutNobel
Piezo channels
2017
Identification and Analysis of Putative Homologues of Mechanosensitive Channels in Pathogenic Protozoa
2013
Nociceptors—Noxious Stimulus Detectors
2007
A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons
2016
A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating
2008 StandoutNobel
Architecture of the mammalian mechanosensitive Piezo1 channel
2015 Nature
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization
2017 StandoutNobel
Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
2016
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
2014 Standout
Thermoregulation: Channels that Are Cool to the Core
2007
Heterologous Expression of the Piezo1-ASIC1 Chimera Induces Mechanosensitive Currents with Properties Distinct from Piezo1
2017
Gating of Transient Receptor Potential Melastatin 8 (TRPM8) Channels Activated by Cold and Chemical Agonists in Planar Lipid Bilayers
2010
DrosophilaPainless Is a Ca2+-Requiring Channel Activated by Noxious Heat
2008
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Sensing pressure with ion channels
2012
Merkel cells and neurons keep in touch
2014 StandoutNobel
N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons
2012
TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice
2009 StandoutNobel
The Met268Pro Mutation of Mouse TRPA1 Changes the Effect of Caffeine from Activation to Suppression
2010
Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis
2016
Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms
2009
Monoterpenoid agonists of TRPV3
2007
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
2018
Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
2017
A family of distal arthrogryposis type 5 due to a novel PIEZO2 mutation
2015
Gain‐of‐function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway
2019
The mechanosensitive Piezo1 channel is required for bone formation
2019
Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
2013
Urothelial ATP signaling: what is its role in bladder sensation?
2016
Piezo1 links mechanical forces to red blood cell volume
2015 StandoutNobel
Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides
2015
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I
2008
Modulation of Thermoreceptor TRPM8 by Cooling Compounds
2012
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
2017
The Hv1 proton channel responds to mechanical stimuli
2016
Molecular and Cellular Limits to Somatosensory Specificity
2008
Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels
2019
Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures
2016
How cells channel their stress: Interplay between Piezo1 and the cytoskeleton
2017
Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine
2017
Molecular Background of Leak K+Currents: Two-Pore Domain Potassium Channels
2010
Conductance and block of hair-cell mechanotransducer channels in transmembrane channel–like protein mutants
2014
Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?
2017
TRP Channels and Pain
2013 StandoutNobel
Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
2014
Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation
2009
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease
2020
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice
2018 StandoutNobel
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K + channels
2014 Nobel
Polycystins and partners: proposed role in mechanosensitivity
2014
TRPM8 acute desensitization is mediated by calmodulin and requires PIP2: distinction from tachyphylaxis
2011
The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells
2015
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Feeling Force: Physical and Physiological Principles Enabling Sensory Mechanotransduction
2015
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
2016
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
2011
Disorders of erythrocyte volume homeostasis
2015
The Roles of iPLA2, TRPM8 and TRPA1 in Chemically Induced Cold Hypersensitivity
2010
Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
2011
Inhibition of transient receptor potential melastatin 8 alleviates airway inflammation and remodeling in a murine model of asthma with cold air stimulus
2018
Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4
2017
Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons
2016
Identification of novel PIEZO1 variants using prenatal exome sequencing and correlation to ultrasound and autopsy findings of recurrent hydrops fetalis
2018
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1
2013
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
2014
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel
2019 Science
PIEZO2 mediates injury-induced tactile pain in mice and humans
2018
OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
2018 StandoutNobel
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
TRP Channels
2007 Standout
The Physiology of Mechanoelectrical Transduction Channels in Hearing
2014
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Dissection of the components for PIP 2 activation and thermosensation in TRP channels
2007
Protein Assembly by Design
2021
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype
2011 StandoutNobel
Works of Jayanti Mathur being referenced
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Piezo1 ion channel pore properties are dictated by C-terminal region
2015 StandoutNobel
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia
2015 StandoutNobel
Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression
2011 StandoutNobel
TRPV1 Is Activated by Both Acidic and Basic pH
2009 StandoutNobel
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
2013 StandoutNobel
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
TRPM8 Is Required for Cold Sensation in Mice
2007 StandoutNobel
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol
2006 StandoutNobel
Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents
2012 StandoutNobel
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
2013 StandoutNobel
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Chemical activation of the mechanotransduction channel Piezo1
2015 StandoutNobel