Citation Impact
Citing Papers
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
2008 Standout
Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
2009
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
EglN2 associates with the NRF 1‐ PGC 1α complex and controls mitochondrial function in breast cancer
2015 StandoutNobel
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
The regulation of cellular metabolism by tumor suppressor p53
2013
Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action
2019 StandoutNobel
High levels of reactive oxygen species in gold nanoparticle-targeted cancer cells following femtosecond pulse irradiation
2013
Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor
2013
ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation
2013
STAT1 Regulates Human Glutaminase 1 Promoter Activity through Multiple Binding Sites in HIV-1 Infected Macrophages
2013
Engineering precision nanoparticles for drug delivery
2020 Standout
Glutamine targeting inhibits systemic metastasis in the VM‐M3 murine tumor model
2010
Stress-induced cytotoxicity of chiral Ag nanoclusters
2014
ROS homeostasis and metabolism: a dangerous liason in cancer cells
2016
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
MYC on the Path to Cancer
2012 Standout
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Brick by brick: metabolism and tumor cell growth
2008
Necroptosis and its role in inflammation
2015 StandoutNature
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
2008 StandoutNature
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
2016
Energy metabolism in tumor cells
2007
Advances in metal-induced oxidative stress and human disease
2011 Standout
Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types
2014
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Glutaminolysis Activates Rag-mTORC1 Signaling
2012
Glutamine and cancer: cell biology, physiology, and clinical opportunities
2013
Cancer Cell Metabolism: Warburg and Beyond
2008 Standout
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Targeting glutamine metabolism in myeloproliferative neoplasms
2015
Otto Warburg's contributions to current concepts of cancer metabolism
2011 Standout
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
2013 Nature
Immuno-Oncology: Emerging Targets and Combination Therapies
2018
SIRT5 regulation of ammonia-induced autophagy and mitophagy
2015
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
2009
Quantification of PDZ Domain Specificity, Prediction of Ligand Affinity and Rational Design of Super-binding Peptides
2004
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis
2013 Standout
Pyruvate kinase type M2 and its role in tumor growth and spreading
2005
Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines
1998
Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
2014
Glutamine: pleiotropic roles in tumor growth and stress resistance
2011
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization
2019 StandoutNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C‐labeled glutamine
2008
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation
2013
Pancreatic Adenocarcinoma
2014 Standout
Mitochondria, Oxidants, and Aging
2005 Standout
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Control of glutamine metabolism by the tumor suppressor Rb
2013
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
2012 Nobel
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Regulation of cancer cell metabolism
2011 Standout
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
2012 StandoutNobel
GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation
2013
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
2012 Nature
Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses
2010
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
2016
Analysis of glutamine dependency in non-small cell lung cancer
2012
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis
2017
Acute L ‐glutamine deprivation compromises VEGF‐a upregulation in A549/8 human carcinoma cells
2007
Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance
2018
Oxidative Stress in Cancer
2020 Standout
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Glutamine metabolism: Role in acid‐base balance*
2004
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Modulation of Cellular Proliferation Alters Glutamine Transport and Metabolism in Human Hepatoma Cells
1994
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase
2003
Imprinting Chemical and Responsive Micropatterns into Metal–Organic Frameworks
2010 StandoutNobel
Changes in mitochondrial reactive oxygen species synthesis during differentiation of skeletal muscle cells
2011
Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
2013
Autophagy
2012
Cutaneous Dermatomyositis: An Updated Review of Treatment Options and Internal Associations
2013
Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents
2007
Targeting mitochondria metabolism for cancer therapy
2014
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
2009 StandoutNature
Role of Reactive Oxygen Species-Mediated Signaling in Aging
2012
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors
2015 StandoutNobel
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
2010
Inflammatory Muscle Diseases
2015 Standout
Atomically Precise Colloidal Metal Nanoclusters and Nanoparticles: Fundamentals and Opportunities
2016 Standout
Photochemically induced fluorescence investigation of a?-cyclodextrin: Azure A inclusion complex and determination of analytical parameters
1995
Nanotube Formation between Cyclodextrins and 1,6-Diphenyl-1,3,5-hexatriene
1996
Regulation of mammalian nucleotide metabolism and biosynthesis
2015
Fundamentals of cancer metabolism
2016 Standout
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
2011
Cancer Cell Metabolism: One Hallmark, Many Faces
2012
Downregulation ofGLS2in glioblastoma cells is related to DNA hypermethylation but not to the p53 status
2015
Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
2015
Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells
2002
PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field
2020
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
2007
BPTES inhibition of hGA124–551, a truncated form of human kidney-type glutaminase
2011
Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor
2011
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
2010
Absorptiometric and spectrofluorimetric study of the inclusion complexes of 2-naphthyloxyacetic acid and 1-naphthylacetic acid with ?-cyclodextrin in aqueous solution
1993
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Autophagy, a key mechanism of oncogenesis and resistance in leukemia
2016
Metabolic reprogramming and cancer progression
2020 StandoutScience
The Stability of Cyclodextrin Complexes in Solution
1997 Standout
Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2
2015
Association of Some Polynuclear Aromatic Hydrocarbons with Cyclodextrins in Aqueous Medium
1989
Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis
2016
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
2015
The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
2010
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
2009
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
2012
Per- and polyfluoroalkyl substances in the environment
2022 StandoutScience
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
2002
p63 regulates glutaminase 2 expression
2013
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas
2003
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
2007
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma
2014
Works of Javier Márquez being referenced
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
2019
Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells
2013
Expression of the scaffolding PDZ protein glutaminase‐interacting protein in mammalian brain
2007
A novel glutaminase isoform in mammalian tissues
2009
Nuclear Localization of L-type Glutaminase in Mammalian Brain
2002
The C‐terminus of human glutaminase L mediates association with PDZ domain‐containing proteins1
2001
Relevance of glutamine metabolism to tumor cell growth
1992
Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death
2002
Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms
2010
Submitochondrial localization and membrane topography of Ehrlich ascitic tumour cell glutaminase
1997
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
2015
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells
2013
Antisense glutaminase inhibition modifies the O‐GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells
2007
Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism
2012
Identification of two human glutaminase loci and tissue-specific expression of the two related genes
2000
Phosphate‐activated glutaminase expression during tumor development
1994
Glutaminase Isoenzymes as Key Regulators in Metabolic and Oxidative Stress Against Cancer
2013
Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells
2004
Transfection with liver‐type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells
2008
Inhibition of glutaminase expression increases Sp1 phosphorylation and Sp1/Sp3 transcriptional activity in Ehrlich tumor cells
2004
Mammalian glutaminase isozymes in brain
2012
Early differential expression of two glutaminase mRNAs in mouse spleen after tumor implantation
1998
Glutamine, Glucose and other Fuels for Cancer
2014
Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis
2008
Treatment of early and refractory dermatomyositis with infliximab: a report of two cases
2006
Glutaminase: A multifaceted protein not only involved in generating glutamate
2006
Enhanced spectrofluorimetric determination of the pesticide warfarin by means of the inclusion complex with β-cyclodextrin
1990
Ehrlich ascites tumor cells expressing anti‐sense glutaminase mRNA lose their capacity to evade the mouse immune system
2001
Glutamine homeostasis and mitochondrial dynamics
2009
Nitrogen metabolism in tumor bearing mice
1989
Granule Localization of Glutaminase in Human Neutrophils and the Consequence of Glutamine Utilization for Neutrophil Activity
2004
Oxidative stress in apoptosis and cancer: an update
2012
Interchange of amino acids between tumor and host
1992
Expression of functional human glutaminase in baculovirus system: Affinity purification, kinetic and molecular characterization
2006
Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells
2000
Glutamine transport by vesicles isolated from tumour-cell mitochondrial inner membrane
1995
Ehrlich ascites tumor cells expressing anti-sense glutaminase mRNA lose their capacity to evade the mouse immune system
2000
Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase
2000
Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells
2000
Inclusion complexes phenanthrene-β-cyclodextrin and their interactions with aliphatic amines
1986
Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase.
2005
Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase
2000
Genomic organization and transcriptional analysis of the human l-glutaminase gene
2003
Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells
1988
Co-expression of glutaminase K and L isoenzymes in human tumour cells
2005
Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells.
1988